Nanoemulsion: Concepts, development and applications in drug delivery

Singh, Yuvraj; Meher, Jaya Gopal; Raval, Kavit; Khan, Fakhar Z.; Chaurasia, Mohini; Jain, Nitin; Chourasia, Manish K.

doi:10.1016/j.jconrel.2017.03.008

Cited by 989 publications

(592 citation statements)

References 174 publications

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“…Even there are many types of surfactant, the nonionic type such as polysorbates are the most popular for pharmaceutical preparations because of their compatibility with various active compounds. In the systems containing oil and water, nonionic surfactants can rapidly adsorb at oil/water interface to reduce the oil/water interfacial tension and provide steric or electrostatic hindrance to the dispersed internal droplets to prevent droplet aggregation (16). Previous literature has reported the developed nanoemulsions of clove oil using polysorbate 80 for enhancing antibacterial activity of clove oil (17).…”

Section: Discussionmentioning

confidence: 99%

Nanoemulsion: A suitable nanodelivery system of clove oil for anesthetizing Nile tilapia

Kheawfu

Pikulkaew

Chaisri

et al. 2017

DD&T

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Section: Discussionmentioning

confidence: 99%

Nanoemulsion: A suitable nanodelivery system of clove oil for anesthetizing Nile tilapia

Kheawfu

Pikulkaew

Chaisri

et al. 2017

DD&T

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“…This implosion creates shockwaves, which in turn create a jet stream of surrounding liquid, pressurizing dispersed droplets and causing size reduction. Investigation into operational parameters has revealed that droplet size decreases with increasing sonication time and input power . In our work, the input power remained constant, at maximum power, and therefore the sonication time was varied.…”

Section: Resultsmentioning

confidence: 76%

“…These systems have many advantages compared to conventional emulsions. Usually, NE can exist as oil‐in‐water (O/W) but can also be water‐in‐oil (W/O) or multiple emulsions W/O/W . Their very large interfacial area positively influences the drug transport and their delivery to target specific sites.…”

Section: Introductionmentioning

confidence: 99%

“…NE has the ability to protect the drugs from hydrolysis and enzymatic degradation, making it an ideal drug delivery carrier. So the major advantages of NEs, as drug delivery system, include increased drug loading, enhanced drug solubility and bioavailability, reduced patient variability, controlled drug release and protection from enzymatic degradation …”

Section: Introductionmentioning

confidence: 99%

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Development and Characterization of Nanoemulsion Containing Almond Oil, Biodegradable Polymer and Propranolol as Potential Treatment in Hemangioma

Coelho

Campos

Freitas

et al. 2018

Macromolecular Symposia

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Hemangiomas are benign tumors, which cause an abnormal proliferation of endothelial cells. In recent years, propranolol (POP) has been used for the therapy of infantile hemangiomas (IH). Topical POP has been prescribed instead of systemic steroids to reduce the risk of side effects. In order to increase the effectiveness of the POP, nanoemulsions (NEs) were developed as drug delivery carriers for topical delivery. NEs are stable dispersions consisting of oil, water and surfactants. To develop NEs water‐in‐oil, POP was solubilized in two concentrations, at 0.25 wt% and 0.5 wt% in water. To prepare the external phase, the almond oil, a biocompatible vegetable oil, was chosen due its anti‐inflammatory properties. An optimal proportion of surfactant and co‐surfactant, Tween 80/Span 80, were assessed by pseudo‐ternary phase diagram. NEs were obtained by ultrasonic processor and the mean droplet size was measured by Dynamic Light Scattering (DLS) and it was less than 300 nm. POP was included in the best formulation for stability studies, Nuclear Magnetic Resonance (NMR) studies, by the analysis of proton relaxation time, cell viability studies and occlusivity test. At the end of the work, the stable NEs, containing POP, diluted above 200 fold, did not affect cell viability and it can be considered as a promising formulation for the treatment of superficial infantile hemangioma.

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“…By definition, nanoemulsions contain droplets that have a mean radius less than 100 nm (McClements, ). The small dimensions of the droplets in nanoemulsions leads to various beneficial physicochemical and physiological attributes, including greater stability to aggregation and gravitational separation, higher optical clarity, larger surface area, faster digestion kinetics, and enhanced bioavailability (McClements & Rao, ; Silva, Cerqueira, & Vicente, ; Singh et al., ). The formulation of any nanoemulsion‐based delivery systems requires optimization of the formulation and processing operations.…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Lutein in Nanoemulsions Stabilized by Resveratrol and Maillard Conjugates

Steiner

Shukla

McClements

et al. 2019

Journal of Food Science

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Lutein is incorporated into foods as a natural yellow pigment and nutraceutical. The introduction of lutein into many foods and beverages, however, is problematic because of its strong hydrophobicity and poor chemical stability. In this research, lutein‐loaded nanoemulsions were prepared to overcome this problem. Casein‐dextran Maillard conjugates or physical complexes were utilized as emulsifiers, while either medium chain triglycerides (MCT) or grape seed oil (GSO) were used as carrier oils. The impact of resveratrol addition on nanoemulsion stability was also examined. The influence of storage temperature, pH, and CaCl2 concentration on the chemical and physical stability of the nanoemulsions was measured. The casein‐dextran conjugates were highly effective at improving the physical resistance of the nanoemulsions to environmental stresses, but had a detrimental effect on their color stability. Conversely, nanoemulsions prepared from casein‐dextran physical complexes were unstable around the protein's isoelectric point (pH 4.6), as well as upon addition of CaCl2. Incorporation of resveratrol and GSO into the nanoemulsions decreased lutein degradation and color fading at all temperatures. This study shows that casein‐dextran conjugates are highly effective at improving the physical stability of lutein‐loaded nanoemulsions, while resveratrol and GSO are effective at improving their chemical stability. Practical Application Lutein can be used by the food industry to create “clean label” and functional food products. The major challenges in incorporating lutein in foods are its poor chemical stability and its high hydrophobicity, which makes it difficult to incorporate. Emulsion‐based delivery systems assembled from natural ingredients may address these challenges. In this study, the impact of Maillard conjugates fabricated from caseinate and dextran, as well as resveratrol addition, on the formation and stability of lutein‐enriched nanoemulsions was determined. The information obtained from this study will help the formulation of more effective functional foods and beverage products.

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Nanoemulsion: Concepts, development and applications in drug delivery

Cited by 989 publications

References 174 publications

Nanoemulsion: A suitable nanodelivery system of clove oil for anesthetizing Nile tilapia

Nanoemulsion: A suitable nanodelivery system of clove oil for anesthetizing Nile tilapia

Development and Characterization of Nanoemulsion Containing Almond Oil, Biodegradable Polymer and Propranolol as Potential Treatment in Hemangioma

Encapsulation of Lutein in Nanoemulsions Stabilized by Resveratrol and Maillard Conjugates

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