Nanoemulsion of Mentha arvensis Essential Oil as an Anticancer Agent in Anaplastic Thyroid Cancer Cells and as an Antibacterial Agent in Staphylococcus aureus

Nirmala, M. Joyce; Durai, Latha; Anusha, Giddaluri Subhadra; Nagarajan, R.

doi:10.1007/s12668-021-00893-8

Cited by 7 publications

(2 citation statements)

References 51 publications

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“…MTT showed that NE were cytotoxic to malignant cells in a dose lower than the free form of EO. The nanometric range of particles allows for a better penetration of blood vessels enhancing the EO effect [39].…”

Section: Discussionmentioning

confidence: 99%

Plant Based Extract Oil-Based Nano emulsions: Impact on Human Melanoma Cell Line

Ellithy,

Abdrabo

2024

Asian Pac J Cancer Prev

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Background: Cancer is a challenge for either the patient or the healthcare manager. Treatment protocols based on chemotherapy or radiotherapy, or both are interfering with the patient's life making him suffer rather than being alleviated. This burden pushed the scientists to search for new regimens that may help ameliorate patient as well as doctor inconvenience. Benefits of plant extracts as medical substitutes in cancer management have been proved. New nano formulated drug delivery systems may help overcoming remedy regimens barriers and obstacles. The present research topic aims to evaluate the anticancer power of two plant extracts in nano emulsion formulation on human melanoma cell line. Methods: Carvacrol and rosemary essential oils were obtained, and nano emulsions were formulated. NE were characterized using TEM for charge and size distribution. The A375 human melanoma cell line was cultured and propagated then IC 50 of prepared NE was added. Assessment of cell cytotoxicity, effect on angiogenesis and apoptosis were tested. Results: After synthesis and characterization, both carvacrol nano emulsion (CNE) and rosemary nano emulsion (RNE) were capable of inhibiting melanoma cell line viability, angiogenesis and they enhanced the expression of caspase-3 proapoptotic marker. Conclusion: Rosemary and carvacrol extract nano emulsions could be a new revolutionary agent in human melanoma therapy and these formulations can be applied locally.

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Section: Discussionmentioning

confidence: 99%

Plant Based Extract Oil-Based Nano emulsions: Impact on Human Melanoma Cell Line

Ellithy,

Abdrabo

2024

Asian Pac J Cancer Prev

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“…For instance, M. longifolia EO has been reported against two human breast cancer cell lines, MDA-MB-468 and MCF-7 (IC50 values not reported) [ 18 ]. However, the IC50 value of M. arvensis EO against the thyroid cancer cell line (HTh-7) was reported at 0.6 μL/mL [ 19 ]. Besides, the cytotoxic effects (IC50 values) of M. spicata EO against human colon cancer (HCT-116), human breast adenocarcinoma (MCF-7), and human ductal carcinoma (T47D) cell lines were reported at 279, 975, and 324 μg/mL [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Nano-scaled emulsion and nanogel containing Mentha pulegium essential oil: cytotoxicity on human melanoma cells and effects on apoptosis regulator genes

Azadi

Osanloo

Zarenezhad

et al. 2023

BMC Complement Med Ther

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Background Topical drug delivery using nanoemulsions and nanogels is a promising approach to treating skin disorders such as melanoma. Methods In this study, the chemical composition of Mentha pulegium essential oil with five major compounds, including pulegone (68.11%), l-menthone (8.83%), limonene (2.90%), iso-pulegone (2.69%), and iso-menthone (1.48%) was first identified using GC-MS (Gas chromatography–Mass Spectrometry) analysis. Afterward, a nano-scaled emulsion containing the essential oil with a droplet size of 7.70 ± 1 nm was prepared. Nanogel containing the essential oil was then prepared by adding (2% w/v) carboxymethyl cellulose to the nano-scaled emulsion. Moreover, the successful loading of M. pulegium essential oil in the nano-scaled emulsion and nanogel was confirmed using ATR-FTIR (Attenuated total reflectance-Fourier Transform InfraRed) analysis. Then, human A375 melanoma cells were treated with different concentrations of samples, the MTT assay evaluated cell viability, and cell apoptosis was confirmed by flow cytometry. In addition, the expression of apoptotic and anti-apoptotic genes, including Bax and Bcl-2, was evaluated using the qPCR (quantitative Polymerase Chain Reaction) technique. Results The results showed that cell viability was reduced by 90 and 45% after treatment with 300 μg/mL of the nanogel and nano-scaled emulsion. As confirmed by flow cytometry, this effect was mediated by apoptosis. Furthermore, gene expression analysis showed up-regulation of Bax and down-regulation of Bcl-2 genes. Therefore, the prepared nanogel, with high efficacy, could be considered a potent anticancer agent for supplementary medicine and in vivo research.

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Uses of Nanoemulsions in Pharmaceuticals Industries

Elshamy,

El-Kashak,

Taher

et al. 2023

Smart Nanomaterials Technology

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Nanoemulsion of Mentha arvensis Essential Oil as an Anticancer Agent in Anaplastic Thyroid Cancer Cells and as an Antibacterial Agent in Staphylococcus aureus

Cited by 7 publications

References 51 publications

Plant Based Extract Oil-Based Nano emulsions: Impact on Human Melanoma Cell Line

Plant Based Extract Oil-Based Nano emulsions: Impact on Human Melanoma Cell Line

Nano-scaled emulsion and nanogel containing Mentha pulegium essential oil: cytotoxicity on human melanoma cells and effects on apoptosis regulator genes

Uses of Nanoemulsions in Pharmaceuticals Industries

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