Nanoemulsion of Minthostachys verticillata essential oil. In-vitro evaluation of its antibacterial activity

Cecchini, Matilde; Paoloni, C.; Campra, Noelia Anahí; Picco, Natalia; Grosso, M.; Pérez, Micaela; Alustiza, Fabrisio; Cariddi, N.; Bellingeri, Romina Valeria

doi:10.1016/j.heliyon.2021.e05896

Cited by 29 publications

(13 citation statements)

References 61 publications

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“…This result is aligned with conclusions reported by Håkansson (2019) 22 , where it was demonstrated that independently of the pressure, the residence time (3–40 ms) on the HPH valve is too short to lead to a thermal-degradation of the labile molecules. Likewise, as showed by Cecchini et al (2021) 54 , negligible alteration (<1%) of the relative composition/abundance was found when the pure and the nanoemulsified essential oil of M. verticillata was evaluated by chromatography analysis prior to and after the emulsification procedure.…”

Section: Resultsmentioning

confidence: 68%

Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability

et al. 2021

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In this study, the interfacial ability of α-terpineol (α-TOH) was reported, followed by its trapping into oil-in-water (O/W) nanoemulsion as active-ingredient and the long-term observation of this nanosystem influenced by the storage-time (410-days) and temperature (5, 25, 50 °C). The results indicated that the α-TOH can reduce the interfacial tension on the liquid-liquid interface (ΔG°m = −1.81 KJ mol−1; surface density = 8.19 × 10−6 mol m−2; polar head group area = 20.29 Å2), in the absence or presence of surfactant. The O/W nanoemulsion loaded with a high amount of α-TOH (90 mg mL−1; 9α-TOH-NE) into the oil phase was successfully formulated. Among the physical parameters, the mean droplet diameter (MDD) showed a great thermal dependence influenced by the storage-temperature, where the Ostwald ripening (OR) was identified as the main destabilizing phenomena that was taking place on 9α-TOH-NE at 5 and 25 °C along with time. Despite of the physical instability, the integrity of both nanoemulsion at 5 °C and 25 °C was fully preserved up to 410th day, displaying a homogeneous and comparable appearance by visual observation. On contrary, a non-thermal dependence was found for chemical stability, where over 88% of the initial amount of the α-TOH nanoemulsified remained in both 9α-TOH-NE at 5 and 25 °C, up to 410th day. Beyond the key data reported for α-TOH, the importance of this research relies on the long-term tracking of a nanostructured system which can be useful for scientific community as a model for a robust evaluation of nanoemulsion loaded with flavor oils.

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Section: Resultsmentioning

confidence: 68%

Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability

et al. 2021

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“…Due to their small size, they are more readily penetrable in the cytoplasmic membranes providing cellular interaction with microbes thus disrupting and enhancing the antimicrobial activity of the bioactive compounds (Idris et al, 2015). The antimicrobial activity of nano encapsulated essential oils has been elucidated in many studies (Cecchini et al, 2021; Sugumar et al, 2015). Essential oil O/W NEs of cinnamon bark, clove leaf, tea tree, and thyme were formulated using ultrasonication method.…”

Section: Essential Oil Ne: New Approaches For Improved Therapeutic Po...mentioning

confidence: 99%

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Jamir,

Bhushan,

Sanjukta

et al. 2023

Biotech & Bioengineering

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In recent years, studies on the formulation of nanoemulsions have been the focus of attention due to their potential applicability in food, pharmaceuticals, cosmetics, and agricultural industries. Nanoemulsions can be formulated using ingredients approved by the Food and Drug Administration (FDA), which assures their safety profiles to a great extent. Bioactive compounds such as essential oils although have strong biological properties and antimicrobial compounds, their usage is restricted due to their high volatility, instability, and hydrophobic nature. Therefore, nanoemulsion as carrier vehicle can be used to encapsulate essential oils to obtain stable and enhanced physicochemical characteristics of the essential oils. This review details the structure, formulation, and characterization techniques used for nanoemulsions, with a focus on the essential oil‐based nanoemulsions which have the potential to be used as antimicrobial and anticancer therapeutics.

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“…The factor that determines of essential oil activity is the functional groups of the composition present in active components. Oxygenated sesquiterpenes exhibit shows better antibacterial activity than hydrocarbons, which can occur by inhibiting the basic microbial rejuvenation process in lipid membrane function (Cecchini et al, 2021;Babarinde et al, 2021). High percentage of sesquiterpenes in Lantana camara L was primary responsible for the antibacterial activities (Zhu et al, 2013).…”

Section: Antibacterial Activities Of Lantana Camara L Flowers Essential Oilmentioning

confidence: 99%

Analysis of Chemical Components and Antibacterial Activity in Essential Oil of Lantana Flowers (Lantana Camara L)

Sembiring¹,

Zuhra

2021

biomedika

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The purpose of this study was to evaluate the essential oil composition as well as antibacterial activities of essential oil of Lantana camara L flowers against four bacterial strains. Essential oil of Lantana camara L flowers was obtained by hydrodistillation method using Sthal and analyzed by GC-MS. The antibacterial activities of essential oil were tested by using disk diffusion method against four bacterial strains. Results showed 72 compounds for Lantana flowers essential oil, of which caryophyllene (10,87%), davanone (9.84%), a-humulene (7.59%), a-curcumene (3.35%), germacrene D (3.09%), calarene (2.42%), a-muurolene (2.27%), p-cymene (1.79%), 1,8 cineole (1.59%) , δ-cadinene (1.59%), a-copaene (1.12%), nerolidol B (1%) and ß-ocimene (0.54%) were detected as major components. Antibacterial activity assay of Lantana camara L flowers essential oil was examined against four bacterial strains including Gram (+and-) by using disk diffusion agar method. All the tested Gram (+and-) bacterial strains displayed slight to moderate antibacterial activity (7 – 10 mm) against all concentrations of essential oil. The essential oil of Lantana camara L flowers showed remarkable antibacterial activity with inhibition in concentrations of 10% and 20% against the phatogen bacterias Basillus subtilis (9.6 mm; 10.8 mm), Propionibacterium acnes ( 7.6 mm; 8.7 mm), Eschechia coli ( 8.4 mm ; 9.6 mm) and Pseudomonas aeruginosa ( 8.3 mm ; 9.3 mm) showed from zone of inhibition that was formed, zone of inhibition in concentration 20% was bigger than concentration 10%.

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Nanoemulsion of Minthostachys verticillata essential oil. In-vitro evaluation of its antibacterial activity

Cited by 29 publications

References 61 publications

Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability

Comprehensive study of α-terpineol-loaded oil-in-water (O/W) nanoemulsion: interfacial property, formulation, physical and chemical stability

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Analysis of Chemical Components and Antibacterial Activity in Essential Oil of Lantana Flowers (Lantana Camara L)

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