Nanoemulsions-Based Drug Delivery for Brain Tumors

Ding, Zhiying; Yong-ming, Jiang; Liu, Xianhong

doi:10.1016/b978-0-12-812218-1.00012-9

Cited by 23 publications

(19 citation statements)

References 89 publications

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“…L1, L2 and H1 also contained a 2:1 mixture of the non-ionic surfactants Labrasol (caprylocaproyl polyoxyl-8 glycerides) and Maisine (glyceryl monolinoleate). Caprylocaproyl polyoxyl-8 glycerides have been reported as appropriate surfactant molecules for the formulation of biocompatible o/w nanoemulsions in several studies [ 39 , 40 ]. Maisine is a mixture of monoglycerides, mainly glyceryl monooleate and glyceryl monolinoleate, together with variable quantities of diglycerides and triglycerides, obtained by partial glycerolysis of vegetable oils.…”

Section: Resultsmentioning

confidence: 99%

Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of Lipophilic Compounds

et al. 2020

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Biocompatible nanoemulsions and nanoemulsion-based hydrogels were formulated for the encapsulation and delivery of vitamin D3 and curcumin. The aforementioned systems were structurally studied applying dynamic light scattering (DLS), electron paramagnetic resonance (EPR) spectroscopy and viscometry. In vitro studies were conducted using Franz diffusion cells to investigate the release of the bioactive compounds from the nanocarriers. The cytotoxicity of the nanoemulsions was investigated using the thiazolyl blue tetrazolium bromide (MTT) cell proliferation assay and RPMI 2650 nasal epithelial cells as in vitro model. DLS measurements showed that vitamin D3 and curcumin addition in the dispersed phase of the nanoemulsions caused an increase in the size of the oil droplets from 78.6 ± 0.2 nm to 83.6 ± 0.3 nm and from 78.6 ± 0.2 nm to 165.6 ± 1.0 nm, respectively. Loaded nanoemulsions, in both cases, were stable for 60 days of storage at 25 °C. EPR spectroscopy revealed participation of vitamin D3 and curcumin in the surfactants monolayer. In vitro release rates of both lipophilic compounds from the nanoemulsions were comparable to the corresponding ones from the nanoemulsion-based hydrogels. The developed o/w nanoemulsions did not exhibit cytotoxic effect up to the concentration threshold of 1 mg/mL in the cell culture medium.

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Section: Resultsmentioning

confidence: 99%

Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of Lipophilic Compounds

et al. 2020

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“…The emulsion with a combination of maltodextrin and whey protein as an encapsulant and final pH 6.6, having ζ‐potential of −29 mV, also exhibited a higher encapsulation efficiency of 95% (Talón et al., 2019). Note that, theoretically, ζ‐potential closing to or higher than ± 30 mV indicates a stable emulsion (Ding, Jiang, & Liu, 2018; Krstić, Medarević, Đuriš, & Ibrić, 2018; Li et al., 2020); the higher the ζ‐potential, the more stable the emulsion (Kumar & Dixit, 2017; Selvamani, 2019). Highly stable emulsion can indeed exhibit a higher encapsulation efficiency of up to 98%.…”

Section: Encapsulation Methods Microstructures Encapsulation Efficimentioning

confidence: 99%

Microstructures of encapsulates and their relations with encapsulation efficiency and controlled release of bioactive constituents: A review

Yun

Devahastin

Chiewchan

2021

Comp Rev Food Sci Food Safe

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Vitamins, peptides, essential oils, and probiotics are examples of health beneficial constituents, which are nevertheless heat‐sensitive and possess poor chemical stability. Various encapsulation methods have been applied to protect these constituents against thermal and chemical degradations. Encapsulates prepared by different methods and/or at different conditions exhibit different microstructures, which in turn differently influence the encapsulation efficiency as well as retention of encapsulated core materials. This review provides a summary of various microstructures resulted from the use of selected encapsulation methods or systems, namely, spray coating; co‐extrusion; emulsion‐, micelle‐, and liposome‐based; coacervation; and ionic gelation encapsulation, at different conditions. Subsequent effects of the different microstructures on encapsulation efficiency and retention of encapsulated core materials are mentioned and discussed. Encapsulates having compact microstructures resulted from the use of low‐surface tension and low‐viscosity encapsulants, high‐stability encapsulation systems, lower loads of core materials to total solids of encapsulants and appropriate solidification conditions have proved to exhibit higher encapsulation efficiencies and better retention of encapsulated core materials. Encapsulates with hollow, dent, shrunken microstructures or thinner walls resulted from inappropriate solidification conditions and higher loads of core materials, on the other hand, possess lower encapsulation efficiencies and protection capabilities. Encapsulates having crack, blow‐hole or porous microstructures resulted from the use of high‐viscosity encapsulants and inappropriate solidification conditions exhibit the lowest encapsulation efficiencies and poorest protection capabilities. Compact microstructures and structures formed between ionic biopolymers could be used to regulate the release of encapsulated cores.

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“…Although Figure 13 appears to indicate a difference, this was not statistically significant ( p > 0.05), although, MUP-NE EO and MUP-NE EU were different from control ( p < 0.05). The reduction in the size of the droplets leads to an increase in the surface area of droplets which contributes to the higher solubilisation and release of drug in nanoemulsions [ 66 ]. In addition, the inclusion of essential oils such as EO and EU is also likely to impact release.…”

Section: Resultsmentioning

confidence: 99%

Development of Nanoemulsions for Topical Application of Mupirocin

2023

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Mupirocin (MUP) is a topical antibacterial agent used to treat superficial skin infections but has limited application due to in vivo inactivation and plasma protein binding. A nanoemulsion formulation has the potential to enhance the delivery of mupirocin into the skin. MUP-loaded nanoemulsions were prepared using eucalyptus oil (EO) or eucalyptol (EU), Tween® 80 (T80) and Span® 80 (S80) as oil phase (O), surfactant (S) and cosurfactant (CoS). The nanoemulsions were characterised and their potential to enhance delivery was assessed using an in vitro skin model. Optimised nanoemulsion formulations were prepared based on EO (MUP-NE EO) and EU (MUP-NE EU) separately. MUP-NE EO had a smaller size with mean droplet diameter of 35.89 ± 0.68 nm and narrower particle size index (PDI) 0.10 ± 0.02 nm compared to MUP-NE EU. Both nanoemulsion formulations were stable at 25 °C for three months with the ability to enhance the transdermal permeation of MUP as compared to the control, Bactroban® cream. Inclusion of EU led to a two-fold increase in permeation of MUP compared to the control, while EO increased the percentage by 48% compared to the control. Additionally, more MUP was detected in the skin after 8 h following MUP-NE EU application, although MUP deposition from MUP-NE EO was higher after 24 h. It may be possible, through choice of essential oil to design nanoformulations for both acute and prophylactic management of topical infections.

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Nanoemulsions-Based Drug Delivery for Brain Tumors

Cited by 23 publications

References 89 publications

Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of Lipophilic Compounds

Development and Study of Nanoemulsions and Nanoemulsion-Based Hydrogels for the Encapsulation of Lipophilic Compounds

Microstructures of encapsulates and their relations with encapsulation efficiency and controlled release of bioactive constituents: A review

Development of Nanoemulsions for Topical Application of Mupirocin

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