Nanoemulsions for Enhancement of Curcumin Bioavailability and Their Safety Evaluation: Effect of Emulsifier Type

Gonçalves, Raquel Filipa Silva; Martins, Joana T.; Abrunhosa, Luı́s; Vicente, António A.; Pinheiro, Ana Cristina

doi:10.3390/nano11030815

Cited by 24 publications

(14 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cell viability of caco-2 cells was found to be 87 ± 3.4% at 100 μg/mL of rhamnolipid (Khan et al, 2022). On the contrary, a study by Gonçalves et al (2021) reported cytotoxicity of rhamnolipid-NE on the same cell line owing to a very high concentration (25,000 μg/mL) of rhamnolipid used. The safety of rhamnolipid-NE on plant systems has also been assessed by Mottola et al (2023), wherein Arabidopsis thaliana leaves were exposed to rhamnolipid-NE (200 μg/mL rhamnolipid).…”

Section: Toxicity Of Biosurfactants and Its Nementioning

confidence: 90%

Microbial biosurfactant based nanoemulsions and their applications: A review

Yoosuf,

Nambiar

2023

J Surfact & Detergents

View full text Add to dashboard Cite

Nanoemulsions exhibit a wide range of practical applications owing to their smaller particle size, stability, and enhanced bioavailability. Conventional surfactants widely used in nanoemulsion formulations namely, polysorbate 80, macrogolglycerol ricinoleate, and 4‐octylphenol polyethoxylate have been associated with anaphylactoid responses, alterations in normal flora, cytotoxicity and tissue damage. The use of less toxic, environment‐friendly microbial biosurfactants in the formulation of nanoemulsions have been demonstrated to manifest stability, slow drug release, enhanced skin permeability, and bioactivity. The type and composition of mixed microbial biosurfactants used in nanoemulsions can decrease the droplet size and synergistically increase the stability. Moreover, a lower concentration of drug‐loaded surfactin‐based nanoemulsion synergistically inhibited the proliferation of cancer cells by 50% (IC50). The scope of the current review is to focus on the prospect of substituting conventional surfactants with biosurfactants obtained from microbial origin for nanoemulsion formulations. It also aims to draw attention to the paucity of research in the combinatorial study of biosurfactants and functional drugs used in nanoemulsions. The review emphasizes the bioactivity of microbial biosurfactant‐based nanoemulsions and their applications in diverse sectors. The differences in emulsion stability and size of microbial biosurfactant and conventional surfactant‐based nanoemulsions have been highlighted. The study intends to promote comparative research between nanoemulsions prepared using conventional surfactants and microbial biosurfactants.

show abstract

Section: Toxicity Of Biosurfactants and Its Nementioning

confidence: 90%

Microbial biosurfactant based nanoemulsions and their applications: A review

Yoosuf,

Nambiar

2023

J Surfact & Detergents

View full text Add to dashboard Cite

show abstract

“…Currently, nano-delivery systems are commonly employed to enhance drug dissolution and facilitate the transport of hydrophobic drugs to target tissues (13). Encapsulating curcumin in nanoscale carrier systems such as nanoemulsion signi cantly enhances the e ciency of curcumin, including its bioavailability and solubility (14). The primary classi cations of oil-in-water (O/W) and water-in-oil (W/O) nanoemulsions consist of two immiscible liquids with a surfactant for stabilization.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of curcumin nanoemulsion to inhibit TC-1 cell growth

Karimi,

Qomi,

Jahromy

et al. 2024

Preprint

View full text Add to dashboard Cite

Curcumin (Cur), a substance originating from Curcuma longa, has been comprehensively examined for its anticancer properties. Nonetheless, its clinical application has been restricted by its inadequate solubility, bioavailability, and stability. TC-1 cells have been impressive in understanding HPV biology and developing therapeutic approaches for HPV infection and related cancers, like cervical cancer, offering a close mimicry of HPV-induced carcinogenesis. This study's primary goal is to formulate and optimize curcumin nanoemulsions (Cur-NE) to address these challenges and, secondarily, evaluate their impact on TC-1 cell growth. Characterization of the nanoemulsions was conducted using dynamic light scattering (DLS), transmission electron microscopy (TEM) and High-performance liquid chromatography (HPLC) revealing an average particle size of 52.5 nm, a zeta potential of -13.1 mV, and a drug content of 94.6%. Through the dialysis diffusion technique, drug release profiles demonstrated a sustained, slower release of Cur from Cur-NE compared to free curcumin. According to an MTT assay, Cur-Ne with an IC50 35 µg/ml exhibited an increased inhibitory effect of Cur on TC-1 cancer cells, while showing no inhibitory effects on MC3T3 normal cells at concentrations up to 100 µg/ml. In summary, this study underscores the potential of nanoemulsions as efficient carriers for Cur, with demonstrated safety in both cancer and normal cells. Moreover, Cur-NE displayed substantial inhibitory activity against TC-1 cancer cells, suggesting its promise in treating HPV-associated cancers, particularly cervical cancer. Further research is warranted to evaluate the long-term safety of this nanoemulsion for clinical trials and its efficacy against other cancer cell lines.

show abstract

“…It is important to mention that the smaller the particle size, the higher the degradation rate of the compound [18]. The efficiency of NE to be absorbed by enterocytes is depend on their diameter (20-200 nm); also, the chain length of the oil incorporated is highly related to the bioaccessibility of the bioactive [19]. The advantage of using a designed emulsifier may represent greater abilities and controlled qualities that can be conferred to the system.…”

Section: Introductionmentioning

confidence: 99%