Nanoemulsions for synthesis of biomedical nanocarriers

Elzayat, Asmaa; Adam-Cervera, Inés; Álvarez-Bermúdez, Olaia; Muñoz‐Espí, Rafael

doi:10.1016/j.colsurfb.2021.111764

Cited by 55 publications

(32 citation statements)

References 100 publications

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“…In recent decades, synthetic nanoparticles (NPs) including liposomes [ 1 ], micelles [ 2 ], dendrimers [ 3 ], nanocapsules [ 4 ], nanodiamonds [ 5 ], nanosponges [ 6 ], nanoemulsions [ 7 ] and self-assembled peptides [ 8 ] have been extensively studied for nanomedicine, particularly for targeted cancer therapy. Drug delivery systems can improve the pharmacokinetic and pharmacodynamics profiles of therapeutics that carried, thereby enhancing the therapeutic effects while reducing undesired toxicity and side effects [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial exosomes for translational nanomedicine

et al. 2021

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Exosomes are lipid bilayer membrane vesicles and are emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such as massive production, standard isolation, drug loading, stability and quality control. In recent years, artificial exosomes are emerging based on nanobiotechnology to overcome the limitations of natural exosomes. Major types of artificial exosomes include ‘nanovesicles (NVs)’, ‘exosome-mimetic (EM)’ and ‘hybrid exosomes (HEs)’, which are obtained by top-down, bottom-up and biohybrid strategies, respectively. Artificial exosomes are powerful alternatives to natural exosomes for drug delivery. Here, we outline recent advances in artificial exosomes through nanobiotechnology and discuss their strengths, limitations and future perspectives. The development of artificial exosomes holds great values for translational nanomedicine.

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Section: Introductionmentioning

confidence: 99%

Artificial exosomes for translational nanomedicine

et al. 2021

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“…Emulsions are important in many existing applications such as drug delivery or food products as well as due to their use as micro to nanoscale containers, e.g ., for biomedical applications or their use as reaction vessels for catalysis and polymer synthesis. , In particular, the particle size as well as the surface charge of the dispersed phase plays a major role for the properties and stability of emulsions, while they are also an important model system which allows for more systematic studies on the role of surface properties in colloids. This is different compared to other soft matter interfaces, e.g ., for dispersions of inorganic solid particles where surface modification is not as easily tunable compared to the soft oil/water (o/w) interfaces in emulsions.…”

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confidence: 99%

Nanoscale Effects on the Surfactant Adsorption and Interface Charging in Hexadecane/Water Emulsions

Glikman

Braunschweig

2021

ACS Nano

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Nanoscale properties at interfaces play a key role in the colloidal stability of emulsions and other soft matter materials where physical properties need to be controlled from the nano to macroscopically visible length scales. Our molecular level understanding of oil− water interfaces arises mostly from results at extended interfaces and the common view that emulsions are stabilized by a large number of surfactant molecules at the droplet's interface which, however, has been recently challenged. In this work, we show that the particle size and the curvature of oil droplets at the nanoscale is of great importance for the interface adsorption of dodecyl sulfate surfactants and possible counterion condensation at the charged hexadecane−water interface. Using second-harmonic scattering, we have studied the surface charge of oil droplets in nanoemulsions where we systematically varied the particle size R between 80 and 270 nm and demonstrate that the surface charge density σ changes drastically with size: For sizes >200 nm, σ is similar to what can be expected at flat extended interfaces, while σ is dramatically reduced by almost an order of magnitude when the particle size of the oil droplet is 80 nm. Using a theoretical approach that considers counterion condensation, we quantify the nanoscale effects on the change in surface charge with particle size and find excellent agreement with our experimental result. Modeling of the experimental results also implies that the charge per particle remains constant and depends on a critical balance of surfactant adsorption and ion condensation.

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“…Nanoemulsions are very versatile systems for encapsulating drugs dissolved in the disperse phase [ 89 ]. They can enhance the therapeutic efficacy of the drug and reduce the adverse effect and toxic reactions [ 90 ].…”

Section: Types Of Nanocarriers Used For the Treatment Of Diabetesmentioning

confidence: 99%

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

et al. 2022

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In recent years, natural polysaccharides have been considered as the ideal candidates for novel drug delivery systems because of their good biocompatibility, biodegradation, low immunogenicity, renewable source and easy modification. These natural polymers are widely used in the designing of nanocarriers, which possess wide applications in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. A great deal of studies could be focused on developing polysaccharide nanoparticles and promoting their application in various fields, especially in biomedicine. In this review, a variety of polysaccharide-based nanocarriers were introduced, including nanoliposomes, nanoparticles, nanomicelles, nanoemulsions and nanohydrogels, focusing on the latest research progress of these nanocarriers in the treatment of diabetes and the possible strategies for further study of polysaccharide nanocarriers.

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Nanoemulsions for synthesis of biomedical nanocarriers

Cited by 55 publications

References 100 publications

Artificial exosomes for translational nanomedicine

Artificial exosomes for translational nanomedicine

Nanoscale Effects on the Surfactant Adsorption and Interface Charging in Hexadecane/Water Emulsions

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

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