Nanoencapsulation (in vitro and in vivo) as an efficient technology to boost the potential of garlic essential oil as alternatives for antibiotics in broiler nutrition

Amiri, Nasrin; Afsharmanesh, M.; Salarmoini, M.; Meimandipour, Amir; Hosseini, S A; Ebrahimnejad, Hadi

doi:10.1016/j.animal.2020.100022

Cited by 41 publications

(42 citation statements)

References 36 publications

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“…Both control groups were fed the basal diet without G-NHG supplementation. Correspondingly, birds in the four treated groups were fed the basal diet containing 100, 200, 300 or 400 mg/kg diet of G-NHG [27] and challenged with C. perfringens at 21, 22 and 23 d of age. Broilers were fed mash form diets for starter (d 1-10), grower (d 11-20) and finisher (d 21-38) periods, with free access to feed and drinking water.…”

Section: Birds Diets and Experimental Designmentioning

confidence: 99%

Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model

Ibrahim

Ismail

Khalifa

et al. 2021

Animals

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Necrotic enteritis (NE) caused by Clostridium perfringens (C. perfringens) results in impaired bird growth performance and increased production costs. Nanotechnology application in the poultry industry to control NE outbreaks is still not completely clarified. Therefore, the efficacy of dietary garlic nano-hydrogel (G-NHG) on broilers growth performance, intestinal integrity, economic returns and its potency to alleviate C. perfringens levels using NE challenge model were addressed. A total of 1200 male broiler chicks (Ross 308) were assigned into six groups; four supplemented with 100, 200, 300 or 400 mg of G-NHG/kg diet and co-challenged with C. perfringens at 21, 22 and 23 d of age and two control groups fed basal diet with or without C. perfringens challenge. Over the total growing period, the 400 mg/kg G-NHG group had the most improved body weight gain and feed conversion efficiency regardless of challenge. Parallel with these results, the mRNA expression of genes encoding digestive enzymes (alpha 2A amylase (AMY2A), pancreatic lipase (PNLIP) and cholecystokinin (CCK)) and intestinal barriers (junctional adhesion molecule-2 (JAM-2), occludin and mucin-2 (Muc-2)) were increased in groups fed G-NHG at higher levels to be nearly similar to those in the unchallenged group. At 14 d post challenge, real-time PCR results revealed that inclusion of G-NHG led to a dose-dependently decrease in the C. perfringens population, thereby decreasing the birds’ intestinal lesion score and mortality rates. Using 400 mg/kg of G-NHG remarkably ameliorated the adverse effects of NE caused by C. perfringens challenge, which contributed to better growth performance of challenged birds with rational economic benefits.

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Section: Birds Diets and Experimental Designmentioning

confidence: 99%

Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model

Ibrahim

Ismail

Khalifa

et al. 2021

Animals

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“…Intestinal symbiotic bacteria generally colonize the outer mucus layer. The polymerized Mucin2 network structure prevents intestinal bacteria from invading the mucosal layer ( Amiri et al, 2021 ). In the present study, one unanticipated finding was that the sIgA level of the ileal mucosa and the mRNA level of the Mucin-2 in the ileum were dropped with 500 mg/kg SS supplementation, whereas the number of goblet cells was not affected by the addition of SS.…”

Section: Discussionmentioning

confidence: 99%

Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens

Gao¹,

Fu²,

Yan³

et al. 2022

Poultry Science

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“…Different delivery systems loaded with entrapped EOs have been developed and when tested in vitro (Ghodrati et al., 2019 ; Sugumar et al., 2015 ) and in vivo (Alam et al., 2018 ) they proved to improve efficacy of EOs as antimicrobials. Moreover, nanodelivered EOs incorporated directly in animal food proved to be effective in reducing the rate of food-borne infections in animals, in particular because of bacteria (Nouri, 2019 ; Amiri et al., 2020 ; Hosseini & Meimandipour, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications

et al. 2022

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This review provides a synthesis of the last ten years of research on nanodelivery systems used for the delivery of essential oils (EOs), as well as their potential as a viable alternative to antibiotics in human and veterinary therapy. The use of essential oils alone in therapy is not always possible due to several limitations but nanodelivery systems seem to be able to overcome these issues. The choice of the essential oil, as well as the choice of the nanodelivery system influences the therapeutic efficacy obtained. While several studies on the characterization of EOs exist, this review assesses the characteristics of the nanomaterials used for the delivery of essential oils, as well as impact on the functionality of nanodelivered essential oils, and successful applications. Two classes of delivery systems stand out: polymeric nanoparticles (NPs) including chitosan, cellulose, zein, sodium alginate, and poly(lactic-co-glycolic) acid (PLGA), and lipidic NPs including nanostructured lipid carriers, solid lipid NPs, nanoemulsions, liposomes, and niosomes. While the advantages and disadvantages of these delivery systems and information on stability, release, and efficacy of the nanodelivered EOs are covered in the literature as presented in this review, essential information, such as the speed of emergence of a potential bacteria resistance to these new systems, or dosages for each type of infection and for each animal species or humans is still missing today. Therefore, more quantitative and in vivo studies should be conducted before the adoption of EOs loaded NPs as an alternative to antibiotics, where appropriate.

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Nanoencapsulation (in vitro and in vivo) as an efficient technology to boost the potential of garlic essential oil as alternatives for antibiotics in broiler nutrition

Cited by 41 publications

References 36 publications

Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model

Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model

Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens

Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications

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