Nanoencapsulation of Alpha‐linolenic Acid with Modified Emulsion Diffusion Method

Habib, Salam; Amr, Ayed; Hamadneh, Imad

doi:10.1007/s11746-011-1960-3

Cited by 22 publications

(11 citation statements)

References 28 publications

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“…The different flow rate ratio can affect the rate of diffusion between water and miscible organic solvent, water solubility of PLGA and drug, and the rate of crystallization. The decrease of proportion of organic solvent increased the particle size of PLGA nanoparticles in other report, 38) which is evidence that PLGA is prepared by the process of crystallization. In contrast, there is different tendency about the flow rate ratio when liposome was prepared as described below.…”

Section: )supporting

confidence: 60%

“…This means that liposome has different mechanism about its formation. In this study, the drastic change of flow rate ratio did not lead the change of particle size compared with typical stirring (such as 38) ). Additionally, PLGA nanoparticles generated using other microfluidics systems showed increased diameters upon changing the flow rate ratio from, 39) providing other example of different tendencies using different microfluidics systems.…”

Section: )mentioning

confidence: 52%

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The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

Morikawa

Tagami

Hoshikawa

et al. 2018

Biological & Pharmaceutical Bulletin

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Microfluidics is a promising system for efficiently optimizing the experimental conditions for preparing nanomedicines, such as self-assembled nanoparticles. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles are promising drug carriers allowing sustained drug release. Here, we encapsulated the model drug curcumin, which has many pharmacological activities, into PLGA nanoparticles and investigated the effects of experimental conditions on the resulting PLGA nanoparticles using a microfluidics system with a staggered herringbone structure that can stir solutions through chaotic advection. The total flow rate and flow rate ratio of the solutions in the microfluidics system affected the diameters, polydispersity index, and encapsulation efficiency of the resulting PLGA nanoparticles and produced small, homogenous PLGA nanoparticles. The incorporation of polyethylene glycol (PEG)-PLGA into the PLGA nanoparticles reduced the particle size and improved the encapsulation efficiency. Initial burst release from the PLGA nanoparticles was prevented by the incorporation of PEG2000-PLGA. Curcumin-loaded PEGylated PLGA nanoparticles showed cytotoxicity similar to that of other formulations. This microfluidics system allows high throughput and is scalable for the efficient preparation of PLGA nanoparticles and PEGylated PLGA nanoparticles. Our results will be useful for developing novel PLGA-based polymer nanoparticles by using the microfluidics.

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Section: )supporting

confidence: 60%

Section: )mentioning

confidence: 52%

The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

Morikawa

Tagami

Hoshikawa

et al. 2018

Biological & Pharmaceutical Bulletin

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“…In another study, when the surfactant Tween 20 was used as a stabilizer, the resulting nanocapsules had higher absolute zeta potential values than those produced using the surfactant Pluronic‐F‐68 or gelatin, while no significant difference in zeta potentials was found when either Pluronic‐F68 or gelatin was used . Other investigators have recorded similar findings.…”

Section: Resultsmentioning

confidence: 69%

Characterization of nanocapsules containing Elaeagnus angustifolia L. extract prepared using an emulsion–diffusion process

Esmaeili

Niknam

2013

Flavour & Fragrance J

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Nanocapsules loaded with bioactive compounds derived from medicinal plants have numerous possibilities in the development of biochemical delivery systems. Elaeagnus angustifolia L., commonly known as Russian olive, is used in traditional medicinal in the Middle East as an analgesic for arthritis and joint pain. Because E. angustifolia contains vitamin A, vitamin B, abundant calcium, and vitamin K, an effective coagulant, it has been considered as potentially beneficial in wound healing and scar formation, as well as in the treatment or prevention of osteoporosis. Nanocapsules containing an E. angustifolia‐filled core can be fabricated employing polymerization. In this process, nanocapsules are prepared using poly ethylene glycol–poly butylene adipate–poly ethylene glycol (PEG‐PBA‐PEG) as a shell surrounding a core of E. angustifolia and olive oil. In this study, the relative proportions of polymer and oil, concentrations of polymer and bioactive compound, and presence or absence of various surfactants in different concentrations were investigated in relation to the particle size of the final product. A comparison of samples obtained using the surfactants Tween 80, Tween 60, poly vinyl alcohol (PVA), mixed Tween 80 and PVA, and mixed Tween 80 and Tween 60 showed Tween 80 to result in the smallest particle size. An oil‐to‐polymer ratio of 1:0.25 resulted in the smallest nanoparticle size. Smaller nanoparticles sizes were obtained using lower concentrations of polymer and higher concentrations of the bioactive compound. Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, particle size analysis, and scanning electron microscopy were used to identify and characterize the nanocapsules. Copyright © 2013 John Wiley & Sons, Ltd.

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“…Nanocapsule dispersions of less than 100 nm in size with a zeta potential of 33 mV were obtained. Acetone, as compared to ethyl acetate, and Tween 20, as compared to pluronic-F68 and gelatin, were effective for producing smaller capsules (Habib et al, 2012).…”

Section: Introductionmentioning

confidence: 96%

Characteristics of freeze-dried nanoencapsulated fish oil with whey protein concentrate and gum arabic as wall materials

et al. 2019

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Fish oil has many health effects, but due to its strong odor and rapid spoilage, its use in food formulations is limited. For these reasons, nanoencapsulation of fish oil can be important. The purpose of this study was to investigate the influence of whey protein concentrate (WPC) and gum arabic as wall materials on the characteristics of nanoencapsulated fish oil powder. Gum arabic and WPC were used in varying amounts for nanoencapsulation of fish oil. An oil-in-water emulsion with 6% fish oil and 20% aqueous solution of wall materials was prepared by sonication (24 kHz for 120 sec). The diameter of the emulsion droplets was measured by particle size analysis and they then were dried in a freeze-drier. The results showed that the type and concentration of wall material influenced the characteristics of the nanocapsules. The smallest emulsion droplet diameter (50 nm) and the highest encapsulation efficiency were found in the sample containing 100% gum arabic; however, the lowest amount of surface oil, pH and highest zeta potential and moisture content also were recorded for this sample. Ot can be concluded that gum arabic is more suitable for nanoencapsulation and could appropriately contain the volatile compounds within the capsules.

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Nanoencapsulation of Alpha‐linolenic Acid with Modified Emulsion Diffusion Method

Cited by 22 publications

References 28 publications

The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

The Use of an Efficient Microfluidic Mixing System for Generating Stabilized Polymeric Nanoparticles for Controlled Drug Release

Characterization of nanocapsules containing Elaeagnus angustifolia L. extract prepared using an emulsion–diffusion process

Characteristics of freeze-dried nanoencapsulated fish oil with whey protein concentrate and gum arabic as wall materials

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