Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability

Zannou, Oscar; Oussou, Kouame Fulbert; Chabi, Ifagbémi Bienvenue; Awad, Nour M. H.; Aïssi, Midimahu V.; Gökşen, Gülden; Mortaş, Mustafa; Öz, Fatih; Proestos, Charalampos; Kayodé, A.P.P.

doi:10.3390/nano13030617

Cited by 11 publications

(6 citation statements)

References 119 publications

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“…The object recognition ability test is a task founded on spontaneous behaviors used in impaired rodents to evaluate novel object recognition. Animals are then exposed to familiar objects, setting a novel object to spend less time exploring familiar objects than novel objects [42]. In our investigation, nasal administration of GH/CeO 2 NPs to AD mice causes a higher perception of novel objects than the control group, supporting a markedly neuroprotective effect improved in cognitive impairment.…”

Section: Discussionmentioning

confidence: 59%

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Pérez Gutiérrez,

Rodríguez-Serrano,

Laguna-Chimal

et al. 2024

IJMS

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Alzheimer’s disease is associated with protein aggregation, oxidative stress, and the role of acetylcholinesterase in the pathology of the disease. Previous investigations have demonstrated that geniposide and harpagoside protect the brain neurons, and cerium nanoparticles (CeO2 NPs) have potent redox and antioxidant properties. Thus, the effect of nanoparticles of Ce NPs and geniposide and harpagoside (GH/CeO2 NPs) on ameliorating AD pathogenesis was established on AlCl3-induced AD in mice and an aggregation proteins test in vitro. Findings of spectroscopy analysis have revealed that GH/CeO2 NPs are highly stable, nano-size, spherical in shape, amorphous nature, and a total encapsulation of GH in cerium. Treatments with CeO2 NPs, GH/CeO2 NPs, and donepezil used as positive control inhibit fibril formation and protein aggregation, protect structural modifications in the BSA-ribose system, have the ability to counteract Tau protein aggregation and amyloid-β1–42 aggregation under fibrillation condition, and are able to inhibit AChE and BuChE. While the GH/CeO2 NPs, treatment in AD induced by AlCl3 inhibited amyloid-β1–42, substantially enhanced the memory, the cognition coordination of movement in part AD pathogenesis may be alleviated through reducing amyloidogenic pathway and AChE and BuChE activities. The findings of this work provide important comprehension of the chemoprotective activities of iridoids combined with nanoparticles. This could be useful in the development of new therapeutic methods for the treatment of neurodegenerative diseases.

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Section: Discussionmentioning

confidence: 59%

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Pérez Gutiérrez,

Rodríguez-Serrano,

Laguna-Chimal

et al. 2024

IJMS

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“…Cyanidin-3-O-glucoside (C3G), belonging to anthocyanins, is a flavonoid widely distributed in plants, especially in black rice, black bean, and purple sweet potato [ 177 , 178 ]. C3G is one of the main components of mulberry anthocyanins, which have been widely used in food and health products.…”

Section: Molecular Mechanism Of Natural Products Regulating Ferroptos...mentioning

confidence: 99%

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Zhang,

Luo,

et al. 2024

Eur J Med Res

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The progression of heart failure (HF) is complex and involves multiple regulatory pathways. Iron ions play a crucial supportive role as a cofactor for important proteins such as hemoglobin, myoglobin, oxidative respiratory chain, and DNA synthetase, in the myocardial energy metabolism process. In recent years, numerous studies have shown that HF is associated with iron dysmetabolism, and deficiencies in iron and overload of iron can both lead to the development of various myocarditis diseases, which ultimately progress to HF. Iron toxicity and iron metabolism may be key targets for the diagnosis, treatment, and prevention of HF. Some iron chelators (such as desferrioxamine), antioxidants (such as ascorbate), Fer-1, and molecules that regulate iron levels (such as lactoferrin) have been shown to be effective in treating HF and protecting the myocardium in multiple studies. Additionally, certain natural compounds can play a significant role by mediating the imbalance of iron-related signaling pathways and expression levels. Therefore, this review not only summarizes the basic processes of iron metabolism in the body and the mechanisms by which they play a role in HF, with the aim of providing new clues and considerations for the treatment of HF, but also summarizes recent studies on natural chemical components that involve ferroptosis and its role in HF pathology, as well as the mechanisms by which naturally occurring products regulate ferroptosis in HF, with the aim of providing reference information for the development of new ferroptosis inhibitors and lead compounds for the treatment of HF in the future.

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“…Encapsulation of C3G presents a viable strategy to address these challenges, which may provide effective delivery of C3G to better suppress the cytotoxicity by exerting antioxidant activity. 10 Nutriosomes represent an innovative class of phospholipid nanocarriers incorporating a water-soluble fiber derived from the dextrinization of wheat (Nutriose FB06) or corn. These systems can be synthesized via an environmentally friendly selfassembly process, yielding predominantly unilamellar nanovesicles.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Specifically, C3G has been shown to facilitate the nuclear translocation of erythroid-related factor 2 (Nrf2), consequently increasing the expression of heme oxygenase 1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), thereby decreasing ROS levels. − Nevertheless, C3G is prone to instability and susceptibility to various factors, including oxygen, pH, and enzymatic degradation, resulting in diminished bioavailability and bioactivity. Encapsulation of C3G presents a viable strategy to address these challenges, which may provide effective delivery of C3G to better suppress the cytotoxicity by exerting antioxidant activity …”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl Chitosan-Coated Cyanidin-3-O-Glucoside-Beared Nanonutriosomes Suppress Palmitic Acid-Induced Hepatocytes Injury

Liu,

Karim,

Rashwan

et al. 2024

J. Agric. Food Chem.

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Cyanidin-3-O-glucoside (C3G) is classified as an anthocyanin (ACN) and is recognized for its remarkable antioxidant properties. Yet, the inadequate physicochemical stability of C3G restricts its potential for various biological applications. Thus, in this study, carboxymethyl chitosan (CMC)-coated nanonutriosomes (NS) were synthesized as a novel carrier for encapsulating C3G (CMC-C3G-NS) to improve C3G stability. CMC-C3G-NS exhibited a diameter of less than 200 nm along with an encouraging encapsulation efficiency exceeding 90%. Notably, the formulated CMC-C3G-NS possessed better stability under various pH, ionic, and oxygen conditions, improved controlled release properties, and higher hepatocellular uptake than uncoated particles (C3G-NS), indicating a longer retention time of C3G in a physiological environment. Of utmost significance, CMC-C3G-NS demonstrated superior alleviating effects against palmitic acid (PA)-induced oxidative hepatic damage compared to C3G-NS. Our study provided promising nanocarriers with the potential to deliver hydrophilic ACNs and controlled release properties for PA-induced hepatotoxicity alleviation.

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Nanoencapsulation of Cyanidin 3-O-Glucoside: Purpose, Technique, Bioavailability, and Stability

Cited by 11 publications

References 119 publications

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Geniposide and Harpagoside Functionalized Cerium Oxide Nanoparticles as a Potential Neuroprotective

Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure

Carboxymethyl Chitosan-Coated Cyanidin-3-O-Glucoside-Beared Nanonutriosomes Suppress Palmitic Acid-Induced Hepatocytes Injury

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