Nanoencapsulation of general anaesthetics

Abdoullateef, Basma M. T.; El-Din Al-Mofty, Saif; Azzazy, Hassan M. E.

doi:10.1039/d3na01012k

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…While ketamine’s potential as a therapeutic agent is significant, its use is accompanied by various adverse effects that necessitate cautious clinical application ( Rolfzen et al, 2024 ). During ketamine infusion, common acute side effects such as dissociation, hallucinations, dizziness, and transient increases in blood pressure and heart rate may occur ( Weiner et al, 2000 ; Timm et al, 2008 ; Kalsi et al, 2011 ; Guglielminotti et al, 2019 ; Abdoullateef et al, 2024 ). Prolonged or frequent use can lead to more severe consequences, including cognitive decline, urinary and gastrointestinal issues, as well as the risk of abuse and dependency ( Weiner et al, 2000 ; Morgan and Curran, 2006 ; Cvrček, 2008 ; Kalsi et al, 2011 ; Niesters et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis

Wang,

Chang,

Chen

2024

Front. Neurosci.

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BackgroundDespite this growing interest, there remains a lack of comprehensive and systematic bibliometric analyses of ketamine research. This study aimed to summarize the progress in ketamine research through bibliometric analysis, providing insights into the development and direction of the field.MethodsPublications related to ketamine were retrieved from the Web of Science Core Collection (WoSCC) database on February 15, 2024. In conducting a comprehensive bibliometric analysis, a variety of bibliographic elements were meticulously collected to map the landscape of research within a specific field.ResultsBetween January 1, 2014, and December 31, 2023, a total of 10,328 articles on ketamine research were published across 1,752 academic journals by 45,891 authors from 8,914 institutions in 128 countries. The publication volume has shown a steady increase over this period. The United States of America (USA) and the People’s Republic of China lead in both publication and citation counts. The National Institute of Mental Health (NIMH) and Yale University emerge as the most active institutions in this research domain. Carlos Zarate of the NIH National Institute of Mental Health was noted for the highest number of significant publications and received the most co-citations. The analysis revealed key research themes including mechanism of action, adverse events, psychiatric applications, and perioperative implications.ConclusionThis study provided comprehensive bibliometric and knowledge mapping analysis of the global ketamine research landscape, offering valuable insights into the trends, key contributors, and thematic focus areas within the field. By delineating the evolution of ketamine research, this study aims to guide future scholarly endeavors and enhance our understanding of ketamine’s therapeutic potential.

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Section: Introductionmentioning

confidence: 99%

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis

Wang,

Chang,

Chen

2024

Front. Neurosci.

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Synchronized Chromatin Organization Serves as Potent Biomarker in Anaesthesia-based Plant Consciousness

Chandra,

Mukherjee,

Salam

et al. 2024

Preprint

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Anaesthesia has been used for centuries for medical purposes. With the application of anaesthesia, organisms lose their conscious awareness. It provides a temporary loss of sensation, which enables painless performance during surgery. However, the cellular mechanisms underlying the effects of anaesthesia are not clearly understood. It has been proposed that plant root function is analogous to the human brain. Here, using super-resolution imaging technique, we explored an organelle-level understanding of the effect of anaesthesia on plant roots and the stem connecting to the root. Our results showed that the nuclei organized themselves in an orchestrated manner upon treatment with both local and general anaesthesia without damaging their structure. Euchromatin within the nucleus was found to be reorganized in the nuclear periphery, and this process was found to be independent of ATP. In contrast, mitochondria, microtubules, endocytic vesicles, and chloroplasts, which are other important organelles in plant cells, were highly altered or damaged under the same experimental conditions. Eventually, the cellular homeostasis again maintained and process is reversible upon the removal of anaesthesia. Our results suggest that such orchestrated chromatin organization without disturbing the overall structure of the nucleus could be used as a potent biomarker for conscious awareness in plants.

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Nanoencapsulation of general anaesthetics

Abstract: General anaesthetics (etomidate, ketamine, propofol) may be encapsulated in different nanocarriers to facilitate their ability to cross the blood brain barrier while reducing their side effects.

Cited by 2 publications

References 67 publications

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis

Research trends and hotspots of ketamine from 2014 to 2023: a bibliometric analysis

Synchronized Chromatin Organization Serves as Potent Biomarker in Anaesthesia-based Plant Consciousness

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