Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability

Yin, Juan Juan; Xiang, Cuiyu; Song, Xiaoyong

doi:10.1016/j.ijpharm.2016.05.007

Cited by 21 publications

(8 citation statements)

References 32 publications

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“…New pharmaceutical forms such as nanoencapsulation have been developed to increase the reduced bioavailability of PSO (Yi et al, 2008;Chen et al, 2017;Zhang et al, 2019). The results of Yin et al (2016) demonstrate that nanoencapsulation of PSO (via chitosan and Eudragit S100) increased the oral delivery efficacy. By FIGURE 1 | Chemical structure of psoralidin (3,9-dihydroxy-2-prenylcoumestan).…”

Section: Bioavailability Of Psoralidinmentioning

confidence: 93%

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

et al. 2020

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Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "Cullen corylifolium" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.

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Section: Bioavailability Of Psoralidinmentioning

confidence: 93%

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

et al. 2020

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“…Nanocapsules have been applied to enhance the oral bioavailability of a wide variety of drugs, including fondaparinux [127], sn-38 [128], paclitaxel [129,130], exenatide [131], tacrolimus [132], psorialidin [133] or furosemide [134], as well as of nutraceuticals, such as curcumin [135], lutein [136] or resveratrol [137,138]. As an example, Peltier et al developed paclitaxel-loaded nanocapsules that were able to enhance the bioavailability of the anti-tumour drug after oral administration to rats.…”

Section: Nanocapsulesmentioning

confidence: 99%

Current approaches in lipid-based nanocarriers for oral drug delivery

Plaza-Oliver

Santander-Ortega

Lozano

2021

Drug Deliv. and Transl. Res.

111

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Graphical abstract Lipid-based nanocarriers have gained much interest as carriers of drugs with poor oral bioavailability because of their remarkable advantages like low toxicity, affordable scale-up manufacture, strong biocompatibility or high drug loading efficiency. The potential of these nanocarriers lies in their ability to improve the gastrointestinal stability, solubility and permeability of their cargo drugs. However, achieving efficient oral drug delivery through lipid-based nanocarriers is a challenging task, since they encounter multiple physicochemical barriers along the gastrointestinal tract, e.g. the gastric acidic content, the intestinal mucus layer or the enzymatic degradation, that they must surmount to reach their target. These limitations may be turned into opportunities through a rational design of lipid-based nanocarriers. For that purpose, this review focuses on the main challenges of the oral route indicating the strategies undertaken for lipid-based nanocarriers in order to overcome them. Understanding their shortcomings and identifying their strengths will determine the future clinical success of lipid-based nanocarriers.

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“… Tumor-bearing SCID/Beige mice after subcutaneous injection of PANC-1 (human pancreas carcinoma) cells Passive PCLnanocarriers 137 Methotrexate Orally or i.v. Healthy or tumor-bearing C57Bl/6 mice after intracranial implantation of GL261 (murine glioma) cells Passive Chitosan and Eudragit S100 nanocarriers 138 Psoralidin Orally Healthy Sprague-Dawley rats Passive PCL nanocarriers 139 Resveratrol i.p. Tumor-bearing C57BL/6J mice after subcutaneous injection of B16F10 (murine melanoma) cells Passive PLA nanocarriers 140 Tamoxifen i.v.…”

Section: Polymeric Nanocarriers For Anti-cancer Drugsmentioning

confidence: 99%

<p>Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature</p>

Karabasz¹,

Bzowska²,

Szczepanowicz³

2020

IJN

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Polymeric nanomaterials have become a prominent area of research in the field of drug delivery. Their application in nanomedicine can improve bioavailability, pharmacokinetics, and, therefore, the effectiveness of various therapeutics or contrast agents. There are many studies for developing new polymeric nanocarriers; however, their clinical application is somewhat limited. In this review, we present new complex and multifunctional polymeric nanocarriers as promising and innovative diagnostic or therapeutic systems. Their multifunctionality, resulting from the unique chemical and biological properties of the polymers used, ensures better delivery, and a controlled, sequential release of many different therapeutics to the diseased tissue. We present a brief introduction of the classical formulation techniques and describe examples of multifunctional nanocarriers, whose biological assessment has been carried out at least in vitro. Most of them, however, also underwent evaluation in vivo on animal models. Selected polymeric nanocarriers were grouped depending on their medical application: anti-cancer drug nanocarriers, nanomaterials delivering compounds for cancer immunotherapy or regenerative medicine, components of vaccines nanomaterials used for topical application, and lifestyle diseases, ie, diabetes.

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Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability

Cited by 21 publications

References 32 publications

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action

Current approaches in lipid-based nanocarriers for oral drug delivery

<p>Biomedical Applications of Multifunctional Polymeric Nanocarriers: A Review of Current Literature</p>

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