Nanoencapsulation of quercetin and resveratrol into elastic liposomes

Abstract

Based on the fact that quercetin (QUE) and resveratrol (RES) induce a synergic inhibition of the adipogenesis and increase apoptosis in adipocytes, and that sodium deoxycholate (SDC) has necrotic effects, the nanoencapsulation of QUE and RES into SDC-elastic liposomes is proposed as a new approach for dissolving the subcutaneous fat. The concentration of constituents and the effect of the drug incorporation into cyclodextrin inclusion complexes on the stability of QUE/RES-loaded liposomes were studied. The best liposomal formulation reduced the use of phosphatidylcholine and cholesterol in 17.7% and 68.4%, respectively. Liposomes presented a mean diameter of 149nm with a polydispersion index of 0.3. The zeta potential of liposomes was slightly negative (-13.3mV) due to the presence of SDC in the phospholipid bilayer. Encapsulation efficiency of QUE and RES into liposomes was almost 97%. To summarize, QUE/RES-loaded elastic liposomes are stable and suitable for subcutaneous injection, thereby providing a new strategy for reducing subcutaneous fat.

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

“…The results of an in vivo anti-inflammatory activity study showed that GA elastic vesicles had a significant reduction in ear thickness and mass (25.52 and 49.23%) ( p   <  0.05) as compared with a positive control group (triamcinolone acetonide and econazole nitrate cream in the market)[77]CatechinAntioxidentVeregen®In this study were compared catechin-loaded conventional liposomal, deformable conventional liposomal, and deformable liposomes prepared by the reverse-phase evaporation (REV) methodL-α-phosphatidylcholine, cholesterol, sodiumdeoxycholateResults suggested that all liposomal formulations exhibited a prolonged catechin release. Compared with deformable liposomes, the REV deformable liposomes showed a greater deposition of (+)-catechin while catechin solution did not permeate into the porcine ear skin[78]DipotassiumglycyrrhizinateAnti-inflammatoryagent–Studied the possibility of elastic liposomes for skin release of dipotassium glycyrrhizinate (KG) for treatment of acute and chronic dermatitisSoya lecithin (PC) or hydrogenated soya lecithinDipotassium glycyrrhizinate interacted with liposomes disrupting and fluidizing the lipid bilayer, skin deposition increased 4.5-fold compared with aqueous solution while KG was formulated in liposomes[79]KetotifenAntihistaminicZaditor ketotifenIn this study were investigated possible mechanisms of deformable liposomes and ethosomes for improving skin delivery of ketotifen under non-occlusive conditionsPhosphatidylcholine,Tween-80Results suggested that both the penetration-enhancing effect and the intact vesicle permeation into the stratum corneum might play a role in improving skin delivery of drugs by deformable liposomes, under non-occlusive conditions, and that the penetration-enhancing effect was of greater importance in the case of ketotifen[80]Quercetin andresveratrolTo reduce subcutaneousfat–In this study, proposed quercetin and resveratrol-containing SDC-elastic liposomes as a new approach for dissolving the subcutaneous fatSoya phosphatidylcholine cholesterol, stearylamine, sodium deoxycholateResults showed optimized elastic quercetin and resveratrol-loaded liposomes with suitable physicochemical properties and kinetic drug profiles for subcutaneous injection[81]TetanusVaccineAdacel (Tdap)In the present study, elastic vesicle transfersomes, non-ionic surfactant vesicles (niosomes) and liposomes were used to stu...…”

Influence of resveratrol and dihydroquercetin inclusion into phospholipid nanopatricles on their bioavailability and specific activity

“…Учитывая данные о низкой растворимости в воде РЕС и ДГК [9][10][11][12], представляло интерес определить изменение биодоступности этих полифенолов при их встраивании в фосфолипидные наночастицы. Биодоступность полученных композиций РЕС и ДГК определяли в экспериментах на здоровых крысах.…”

“…Однако, из-за плохой растворимости биодоступность этих соединений низка, что в целом препятствует их широкому применению [9,10]. Для преодоления этих недостатков в ряде работ ДГК [11] и РЕС [12,13] включали в липосомы, наблюдая при этом повышение их биологических эффектов.…”

Elastic liposomes as novel carriers: recent advances in drug delivery

“…71 Curcumin Phospholipon 90H, SDC, SC, sodium taurocholate • Poorly soluble cucumin is known for strong antioxidant and anti-inflammatory properties.…”