Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev, Krasimir

doi:10.3390/coatings9100654

Cited by 68 publications

(39 citation statements)

References 92 publications

(131 reference statements)

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“…Despite their significant potential, several challenges remain before AgNPs can be used for routine application in medical practice, including the uncontrolled release of silver ions and potential toxicity to tissue and organs [8][9][10]. Incorporating AgNPs into biocompatible carriers icluding polymeric 2 of 15 hydrogel has been demonstrated to be an effective strategy to preserve the properties of the nanoparticles while simultaneously enhancing their biological efficacy [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

et al. 2021

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Persistent wound infections have been a therapeutic challenge for a long time. Current treatment approaches are mostly based on the delivery of antibiotics, but these are not effective for all infections. Here, we report the development of a sensitive pH-responsive hydrogel that can provide controlled, pH-triggered release of silver nanoparticles (AgNPs). This delivery system was designed to sense the environmental pH and trigger the release of AgNPs when the pH changes from acidic to alkaline, as occurs due to the presence of pathogenic bacteria in the wound. Our results show that the prepared hydrogel restricts the release of AgNPs at acidic pH (pH = 4) but substantially amplifies it at alkaline pH (pH = 7.4 and pH = 10). This indicates the potential use of the hydrogel for the on-demand release of Ag+ depending on the environmental pH. In vitro antibacterial studies demonstrated effective elimination of both Gram-negative and positive bacteria. Additionally, the effective antibacterial dose of Ag+ showed no toxicity towards mammalian skin cells. Collectively, this pH-responsive hydrogel presents potential as a promising new material for the treatment of infected wounds.

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Section: Introductionmentioning

confidence: 99%

“…Antibiotics 2021, 10, x 2 of 15 the properties of the nanoparticles while simultaneously enhancing their biological efficacy [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

et al. 2021

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“…This process was described by ZoBell et al, establishing in their studies that bacteria prefer to colonize a solid substrate, with the bacteria being present on surfaces dramatically higher than in the surrounding medium [27]. Additionally, fungal and mixed infections, that is, infection originated both by bacteria and fungi, have increased lately [28]. Therefore, the development of antibacterial coatings for the different substrates, ceramic, metal and polymeric substrates, is crucial to reduce bacterial adhesion and proliferation.…”

Section: Polymersmentioning

confidence: 98%

“…Different strategies have been investigated in the last few years to prevent bacterial adhesion and subsequent biofilm formation. Most of them are related to surface design and can be classified in broad terms as ( Figure 2): (1) bacterial repelling and (2) bacteria killing surfaces [28]. The mechanism of action of the first one is based on the prevention of biofilm formation, while killing approaches correspond to bactericidal surfaces that lead to the disruption of bacterial cells on contact, leading to cell death.…”

Section: Antibacterial Mechanismsmentioning

confidence: 99%

Antibacterial Coatings for Improving the Performance of Biomaterials

et al. 2020

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Biomedical devices have become essential in the health care. Every day, an enormous number of these devices are used or implanted in humans. In this context, the bacterial contamination that could be developed in implanted devices is critical since it is estimated that infections kill more people than other medical causes. Commonly, these infections are treated with antibiotics, but the biofilm formation on implant surfaces could significantly reduce the effectiveness of these antibiotics since bacteria inside the biofilm is protected from the drug. In some cases, a complete removal of the implant is necessary in order to overcome the infection. In this context, antibacterial coatings are considered an excellent strategy to avoid biofilm formation and, therefore, mitigate the derived complications. In this review, the main biomaterials used in biomedical devices, the mechanism of biofilm formation, and the main strategies for the development of antibacterial coatings, are reviewed. Finally, the main polymer-based strategies to develop antibacterial coatings are summarized, with the aim of these coatings being to avoid the bacteria proliferation by controlling the antibacterial mechanisms involved and enhancing long-term stability.

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“…In contrast, several polymers have exhibited excellent antibacterial activity while avoiding these disadvantages. Such antimicrobial polymeric films should ideally be fabricated such that they are sterile and renewable, while not degrading the durability or reusability of the polymer [8][9][10]. N-halamines are a class of antimicrobial compounds with the advantages of high antimicrobial activity, long-term stability, good durability, easy regeneration, low toxicity and minimal environmental impact [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

A simple method to prepare superhydrophobic and regenerable antibacterial films

Liang

Chen

Zhu³

et al. 2020

Mater. Res. Express

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Macromolecules incorporating N-halamines have shown significant antibacterial properties and can be regenerated by chlorination. In this work, a new type of regenerable material made of nano-sized latex particles having N-H groups was prepared via the emulsion polymerization of methacrylamide and dodecafluoroheptyl methacrylate with divinylbenzene as a crosslinker. The N-H moieties in this polymer were subsequently transformed into N-Cl groups by chlorination with an aqueous sodium hypochlorite solution, and films were prepared by casting on substrates previously coated with a self-adhesive silicone rubber. The nanoparticles and the films were characterized by Fourier transform infrared (FTIR) spectroscopy, x-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), contact angle measurements, scanning electron microscopy (SEM) and microbiological tests. The results showed that F and Cl were successfully incorporated in the nanoparticles, that the films were thermally stable and hydrophobic (with a contact angle of 152°), and that these materials exhibited antimicrobial properties. The N-Cl groups killed bacteria by releasing active chlorine as they transitioned to N-H groups, and could be re-chlorinated with a methanol solution of isocyanuric chloride. FTIR and XPS analyses confirmed this regeneration, while SEM image showed that the morphology of the original microspheres was maintained after re-chlorination. The re-chlorinated films also maintained superhydrophobic and bactericidal characteristics.

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Nanoengineered Antibacterial Coatings and Materials: A Perspective

Cited by 68 publications

References 92 publications

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

pH-Responsive “Smart” Hydrogel for Controlled Delivery of Silver Nanoparticles to Infected Wounds

Antibacterial Coatings for Improving the Performance of Biomaterials

A simple method to prepare superhydrophobic and regenerable antibacterial films

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