Nanoengineered Granular Hydrogel Bioinks with Preserved Interconnected Microporosity for Extrusion Bioprinting (Small 37/2022)

Abstract

Extrusion Bioprinting In article number 2202390, Amir Sheikhi and co‐workers develop a nanoengineered granular bioink (NGB) to enable the extrusion 3D bioprinting of hydrogel microparticle (microgel)–based scaffolds with preserved interconnected microporosity. The reversible self‐assembly of heterogeneously charged colloidal nanoplatelets adsorbed onto gelatin methacryloyl microgels enable the extrudability and shape fidelity of NGB at a low packing state without filling the void spaces among the microgels. This work opens new opportunities for the 3D bioprinting of tissue engineered microporous scaffolds beyond the traditional biofabrication window.

Injectable Granular Hydrogels Enable Avidity-Controlled Biotherapeutic Delivery

“…Importantly, granular hydrogels are desirable for local delivery applications as they are shear-thinning and self-healing, which enables their injection. Furthermore, they possess a highly interconnected porous structure that allows for cell and tissue infiltration. , The composition or structure of the microgels can be tuned, so as to control the physical properties of the hydrogel, − cell–material interactions, − or growth factor delivery. , Many applications have focused on the capacity of these materials to modulate cell response, and Phelps et al have investigated the functionalization of microgels with GH pairs to develop granular hydrogels as a unique microenvironment for cell delivery. − The use of supramolecular interactions between such hydrogels and appropriately modified therapeutic cargo may also be used to enhance drug function, including for immune modulation, but these applications remain unexplored.…”