Nanoengineering Palladium Plasmonic Nanosheets Inside Polymer Nanospheres for Photothermal Therapy and Targeted Drug Delivery

Usón, Laura; Yus, Cristina; Mendoza, Gracia; Leroy, Éric; Irusta, Silvia; Alejo, Teresa; García‐Domingo, David; Larrea, Ane; Arruebo, Manuel; Arenal, Raúl; Sebastián, Víctor

doi:10.1002/adfm.202106932

Cited by 10 publications

(9 citation statements)

References 88 publications

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“…Cancer is a complex and adaptive ecosystem that cannot be easily treated with individual therapies. Although combination therapy based on nanomaterials has recently attracted particular attention [34][35][36], the effective delivery of nanomedicines with sufficient concentration in malignant cells depends strongly on their transport properties under hypoxia and avascular conditions [37]. Therefore, recent studies on anticancer therapy have focused on the development of biomaterials for targeted drug delivery [38].…”

Section: Discussionmentioning

confidence: 99%

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Cheng

Wang

Zhang

et al. 2022

BMC Med

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Background The application of combination therapy for cancer treatment is limited due to poor tumor-specific drug delivery and the abscopal effect. Methods Here, PD-L1- and CD44-responsive multifunctional nanoparticles were developed using a polymer complex of polyethyleneimine and oleic acid (PEI-OA) and loaded with two chemotherapeutic drugs (paclitaxel and chloroquine), an antigen (ovalbumin), an immunopotentiator (CpG), and an immune checkpoint inhibitor (anti-PD-L1 antibody). Results PEI-OA greatly improved the drug loading capacity and encapsulation efficiency of the nanoplatform, while the anti-PD-L1 antibody significantly increased its cellular uptake compared to other treatment formulations. Pharmacodynamic experiments confirmed that the anti-PD-L1 antibody can strongly inhibit primary breast cancer and increase levels of CD4+ and CD8+ T cell at the tumor site. In addition, chloroquine reversed the “immune-cold” environment and improved the anti-tumor effect of both chemotherapeutics and immune checkpoint inhibitors, while it induced strong immune memory and prevented lung metastasis. Conclusions Our strategy serves as a promising approach to the rational design of nanodelivery systems for simultaneous active targeting, autophagy inhibition, and chemotherapy that can be combined with immune-checkpoint inhibitors for enhanced breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Cheng

Wang

Zhang

et al. 2022

BMC Med

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“…8,9 Of particular interest among these plasmon-based photophysical effects is the photothermal effect, 4 which is characterized by the rapid and efficient conversion of light to heat energy in plasmonic nanostructures, shows important applications in the biomedical field, 10−12 especially in cancer therapy 11 and drug delivery. 12 Recently, chirality of the plasmonic nanostructures has attracted much attention, because of their strong asymmetric photophysical properties. 13−27 Well-known examples are the optical circular dichroism (CD) 13 and photothermal CD.…”

mentioning

confidence: 99%

“…Plasmons in metal nanostructures , have been a hot topic in a broad range of scientific research areas, due to their ability to concentrate light into a nanoscale volume, resulting in a tremendous enhancement of the local electromagnetic field. This enhanced field can give rise to various photophysical effects, such as photoelectric, photothermal, − and optomechanical effects. , Of particular interest among these plasmon-based photophysical effects is the photothermal effect, which is characterized by the rapid and efficient conversion of light to heat energy in plasmonic nanostructures, shows important applications in the biomedical field, − especially in cancer therapy and drug delivery . Recently, chirality of the plasmonic nanostructures has attracted much attention, because of their strong asymmetric photophysical properties. − Well-known examples are the optical circular dichroism (CD) and photothermal CD .…”

mentioning

confidence: 99%

Key Role of Asymmetric Photothermal Effect in Selectively Chiral Switching of Plasmonic Dimer Driven by Circularly Polarized Light

Song,

Ji,

et al. 2024

J. Phys. Chem. Lett.

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Strong interaction between circularly polarized light and chiral plasmonic nanostructures can enable controllable asymmetric photophysical processes, such as selective chiral switching of a plasmonic nanorod-dimer. Here, we uncover the underlying physics that governs this chiral switching by theoretically investigating the interplay between asymmetric photothermal and optomechanical effects. We find that the photothermally induced local temperature rises could play a key role in activating the dynamic chiral configurations of a plasmonic dimer due to the temperature-sensitive molecular linkages located at the gap region. Importantly, different temperature rises caused by the opposite handedness of light could facilitate selective chiral switching of the plasmonic dimer driven by asymmetric optical torques. Our analyses on the wavelength-dependent selectively chiral switching behaviors are in good agreement with the experimental observations. This work contributes to a comprehensive understanding of the physical mechanism involved in the experimentally designed photoresponsive plasmonic nanosystems for practical applications.

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“…Therefore, AuPd-PLGA was prepared by the water/oil/water emulsion and solvent evaporation method using a new methodology inspired by a recently reported procedure designed to produce Pd nanosheets in situ in PLGA. 50 (See Figure S2 and experimental details in the Supporting Information.) Images from transmission electron microscopy (TEM and HAADF-STEM) clearly show 2 to 3 nm AuPd NPs embedded inside PLGA nanodrops of approximately 100 nm in diameter (Figure 1c,d and Figure S3).…”

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confidence: 99%

“…Direct encapsulation of preformed AuPd NPs in the PLGA emulsion results in an inconsistent nanoalloy load distribution, making this method inadequate for our goals. Therefore, AuPd-PLGA was prepared by the water/oil/water emulsion and solvent evaporation method using a new methodology inspired by a recently reported procedure designed to produce Pd nanosheets in situ in PLGA . (See Figure S2 and experimental details in the Supporting Information.)…”

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confidence: 99%

In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation

et al. 2023

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Bioorthogonal metallocatalysis has opened up a xenobiotic route to perform nonenzymatic catalytic transformations in living settings. Despite their promising features, most metals are deactivated inside cells by a myriad of reactive biomolecules, including biogenic thiols, thereby limiting the catalytic functioning of these abiotic reagents. Here we report the development of cytocompatible alloyed AuPd nanoparticles with the capacity to elicit bioorthogonal depropargylations with high efficiency in biological media. We also show that the intracellular catalytic performance of these nanoalloys is significantly enhanced by protecting them following two different encapsulation methods. Encapsulation in mesoporous silica nanorods resulted in augmented catalyst reactivity, whereas the use of a biodegradable PLGA matrix increased nanoalloy delivery across the cell membrane. The functional potential of encapsulated AuPd was demonstrated by releasing the potent chemotherapy drug paclitaxel inside cancer cells. Nanoalloy encapsulation provides a novel methodology to develop nanoreactors capable of mediating new-to-life reactions in cells.

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Nanoengineering Palladium Plasmonic Nanosheets Inside Polymer Nanospheres for Photothermal Therapy and Targeted Drug Delivery

Cited by 10 publications

References 88 publications

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Combination of an autophagy inhibitor with immunoadjuvants and an anti-PD-L1 antibody in multifunctional nanoparticles for enhanced breast cancer immunotherapy

Key Role of Asymmetric Photothermal Effect in Selectively Chiral Switching of Plasmonic Dimer Driven by Circularly Polarized Light

In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation

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