Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Zhang, Lei; Qin, Ziguo; Sun, Han; Chen, Xiang; Dong, Jian; Shen, Siyu; Zheng, Liming; Gu, Ning; Jiang, Qing

doi:10.1016/j.bioactmat.2022.02.017

Cited by 59 publications

(44 citation statements)

References 82 publications

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“…Neutrophil exosomes inherit the targeting biomolecules of neutrophils to the inflammatory site, so that the neutrophil exosome-based nanoparticles can be targeted to accumulate in the site of rheumatoid arthritis. Because of the anti-inflammatory effect of neutrophil exosomes and the magnetic resonance imaging effect of Prussian blue nanoparticles, the complexes realized both diagnosis and treatment of rheumatoid arthritis . Zhang et al prepared DOX-loaded neutrophil exosomes by an extrusion method, and superparamagnetic iron oxide nanoparticles (SPIONs) were modified on these exosomes.…”

Section: Nanotechnology Combined With Neutrophil Function For Disease...mentioning

confidence: 99%

“…Because of the anti-inflammatory effect of neutrophil exosomes and the magnetic resonance imaging effect of Prussian blue nanoparticles, the complexes realized both diagnosis and treatment of rheumatoid arthritis. 89 Zhang et al prepared DOX-loaded neutrophil exosomes by an extrusion method, and superparamagnetic iron oxide nanoparticles (SPIONs) were modified on these exosomes. The accumulation of complexes at tumor sites was increased by the dual targeting of tumor chemotaxis by neutrophil exosomes and magnetic targeting of SPIONs.…”

Section: Neutrophil-nanoparticlementioning

confidence: 99%

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Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Wang

Yan

et al. 2022

ACS Biomater. Sci. Eng.

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Neutrophils, the most abundant white blood cells in the human body, are important immune cells responsible for the innate immune response. Neutrophils can migrate to inflammatory areas, such as tumor sites and infection sites, because of chemotaxis. Neutrophil-based nanomaterials, such as neutrophil-nanomaterial composites and neutrophil membranebased nanomaterials, can help the drug or imaging agent gather in the inflammatory area with the help of chemotaxis. In addition, some nanomaterials can interfere with the function of neutrophils to treat tissue damage caused by excessive local accumulation of neutrophils. This review focuses on the interaction between nanomaterials and neutrophils as well as the applications of neutrophil-based nanomaterials and neutrophilinterfering nanomaterials.

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Section: Nanotechnology Combined With Neutrophil Function For Disease...mentioning

confidence: 99%

Section: Neutrophil-nanoparticlementioning

confidence: 99%

Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Wang

Yan

et al. 2022

ACS Biomater. Sci. Eng.

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“…In recent years, MDD systems have been widely developed to treat various diseases [ 107 , 108 ], including tumors, such as designing Fe 3 O 4 nanoparticles-based targeted drug delivery systems to enhance cancer targeting to suppress tumors under static magnetic fields and laser irradiation growth, and the system proved effective for in situ transdermal drug delivery, magnetic fields, and synchronization of laser and biological targeting. Demonstrated in breast cancer models, this system is an effective alternative for the treatment of superficial cancers ( Figure 5 A) [ 109 ]; bone, for example, has developed an exosome derived from neutrophils modified by sub-5 nm ultra-small PBNP (uPB) engineering through click chemistry, which can target deep into cartilage, significantly improve the joint injury of CIA mice, and inhibit the overall severity of arthritis, showing considerable potential in the clinical diagnosis and treatment of arthritis ( Figure 5 B) [ 110 ]; in vascular structures, a developed nanoparticle (MMB-PLGA-PTX) can be used for in-stent restenosis (ISR) treatment that is responsive to external magnetic fields and LIFU. The results showed that magnetic targeting increased the accumulation of MMP-PLGA-PTX 10-fold, while LIFU facilitated the penetration of the released PLGA-PTX into the arterial tissue, thereby increasing the retention time of the released PTX in the stented vascular tissue.…”

Section: Mnps For Vascular Repairmentioning

confidence: 99%

“…Reprinted with permission from Ref. [ 110 ]. Copyright 2022 Copyright Zhang L. et al ( C ) Schematic diagram of magnetic guided and ultrasonic stimulation for the treatment of ISR with targeted and deep penetrating delivery strategies ( a ); Evaluation of MMB-PLGA Rhdomain targeting and penetration of isolated porcine coronary arteries.…”

Section: Figurementioning

confidence: 99%

Vascular Repair by Grafting Based on Magnetic Nanoparticles

et al. 2022

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Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair, including magnetic stimulation, magnetic drive, magnetic resonance imaging, magnetic hyperthermia, magnetic assembly scaffolds, and magnetic targeted drug delivery, which can significantly affect scaffold performance, cell behavior, factor secretion, drug release, etc. Although there are still challenges in the large-scale clinical application of MNPs, its good non-invasive way to participate in vascular repair and the establishment of a continuous detection process is still the future development direction.

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“…Furthermore, neutrophil-derived exosomes engineered with ultrasmall PB nanoparticles (uPB-Exo) have been shown to be effective in treating RA. uPB-Exo selectively accumulated in activated fibroblast-like synoviocytes and acted as mimics of SOD2 and NOX2 in inflamed joints of RA in vivo, subsequently neutralizing proinflammatory factors, alleviating inflammatory synovitis and protecting against cartilage damage in an advanced RA mouse model (Zhang et al, 2022). Selenium (Se) is an essential dietary nutrient and has been reported to have lower serum concentrations in RA patients than healthy individuals (Yu et al, 2016).…”

Section: Nanomaterials Associated With Downregulated Enzymes In Arthr...mentioning

confidence: 99%

Recent advances in enzyme-related biomaterials for arthritis treatment

et al. 2022

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Arthritis is a group of highly prevalent joint disorders, and osteoarthritis (OA) and rheumatoid arthritis are the two most common types. The high prevalence of arthritis causes severe burdens on individuals, society and the economy. Currently, the primary treatment of arthritis is to relieve symptoms, but the development of arthritis cannot be effectively prevented. Studies have revealed that the disrupted balance of enzymes determines the pathological changes in arthritis. In particular, the increased levels of matrix metalloproteinases and the decreased expression of endogenous antioxidant enzymes promote the progression of arthritis. New therapeutic strategies have been developed based on the expression characteristics of these enzymes. Biomaterials have been designed that are responsive when the destructive enzymes MMPs are increased or have the activities of the antioxidant enzymes that play a protective role in arthritis. Here, we summarize recent studies on biomaterials associated with MMPs and antioxidant enzymes involved in the pathological process of arthritis. These enzyme-related biomaterials have been shown to be beneficial for arthritis treatment, but there are still some problems that need to be solved to improve efficacy, especially penetrating the deeper layer of articular cartilage and targeting osteoclasts in subchondral bone. In conclusion, enzyme-related nano-therapy is challenging and promising for arthritis treatment.

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Nanoenzyme engineered neutrophil-derived exosomes attenuate joint injury in advanced rheumatoid arthritis via regulating inflammatory environment

Cited by 59 publications

References 82 publications

Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Usage of Nanoparticles to Alter Neutrophils’ Function for Therapy

Vascular Repair by Grafting Based on Magnetic Nanoparticles

Recent advances in enzyme-related biomaterials for arthritis treatment

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