For two decades, the Technische Universität Ilmenau has been developing high precision Nanopositioning and Nanomeasuring machines (NPMMs). These have proven their potential for nanometer accurate measurements in large volumes up to 200 mm x 200 mm x 25 mm with 5 axis operation in several fields. As these machines operate according to the highest standards of metrology, offer picometer resolution and nanometer uncertainty, the goal is to transfer their unique precision to fabrication and patterning. So far, the NPMMs have been equipped with laser-based as well as tip-based patterning tools, including one photon and two photon polymerization, nanoimprint, scanning probe lithography and combinations of these technologies. The goal is basic research on these technologies, to tackle the evident challenges and explore the concealed limits to estimate the potential for later use in an industrial scale. In this paper, the specifics and advantages of the NPMMs will be described as well as the micro-and nanofabrication tools that are currently worked on. Focus is on the parameters in measurement mode and the accomplished fabrication results.