Nanofiber mat spinal cord dressing-released glutamate impairs blood-spinal cord barrier

Abstract

A b s t r a c t An excessive glutamate level can result in excitotoxic damage and death of central nervous system (CNS) cells, and is involved in the pathogenesis of many CNS diseases. It may also be related to a failure of the blood-spinal cord barrier (BSCB). This study was aimed at examining the effects of extended administration of monosodium gluta-