Nanofibrillated chitosan coated highly ordered titania nanotubes array/graphene nanocomposite with improved biological characters

Rahnamaee, Seyed Yahya; Bagheri, Reza; Heidarpour, Hamed; Vossoughi, Manouchehr; Golizadeh, Mortaza; Samadikuchaksaraei, Alí

doi:10.1016/j.carbpol.2020.117465

Cited by 23 publications

(16 citation statements)

References 43 publications

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“…In the first study, completely regular Ti nanotubes (TNT) were loaded with vancomycin (VA), modified with reduced graphene oxide (RGO), and coated with CS nanofibers [ 25 ]. RGO is expected to have antibacterial and pro-osteogenic effects.…”

Section: Resultsmentioning

confidence: 99%

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

Wildemann

2021

Materials

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Implants and materials are indispensable in trauma and orthopedic surgery. The continuous improvements of implant design have resulted in an optimized mechanical function that supports tissue healing and restoration of function. One of the still unsolved problems with using implants and materials is infection. Trauma and material implantation change the local inflammatory situation and enable bacterial survival and material colonization. The main pathogen in orthopedic infections is Staphylococcus aureus. The research efforts to optimize antimicrobial surfaces and to develop new anti-infective strategies are enormous. This mini-review focuses on the publications from 2021 with the keywords S. aureus AND (surface modification OR drug delivery) AND (orthopedics OR trauma) AND (implants OR nails OR devices). The PubMed search yielded 16 original publications and two reviews. The original papers reported the development and testing of anti-infective surfaces and materials: five studies described an implant surface modification, three developed an implant coating for local antibiotic release, the combination of both is reported in three papers, while five publications are on antibacterial materials but not metallic implants. One review is a systematic review on the prevention of stainless-steel implant-associated infections, the other addressed the possibilities of mixed oxide nanotubes. The complexity of the approaches differs and six of them showed efficacy in animal studies.

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Section: Resultsmentioning

confidence: 99%

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

Wildemann

2021

Materials

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“…Furthermore, when chitosan is incorporated in the form of nanoparticles on the implant surface, it shows a high loading rate and the capacity for sustained drug release. Chitosan [181], chitosan/gelatin [182], chitosan/alginate [107] and chitosan/graphene oxide [183] have also been utilized in the coating of implants.…”

Section: Biopolymersmentioning

confidence: 99%

“…They cultured human mesenchymal stem cells on the Rgo-Ti substrates and found superior bioactivity and osteogenic potential via a cell counting kit-8 assay, an alkaline phosphatase activity assay and alizarin red S staining, suggesting that these graphene derivatives had potent applications in dental implants. Further, Rahnamaee et al assembled both chitosan nanofibers (CH) and reduced graphene oxide (rGO) onto TNTs [183]. This multifunctional coating offered the synergistic effects of CH and rGO against both long-term and short-term antibacterial activity, promoted osteoblast cell viability, prolonged antibiotic release profile and inhibited bacterial biofilm formation.…”

Section: Carbon Compositesmentioning

confidence: 99%

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Zhang

Gulati

et al. 2021

Nanomaterials

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Titanium (Ti) and its alloys offer favorable biocompatibility, mechanical properties and corrosion resistance, which makes them an ideal material choice for dental implants. However, the long-term success of Ti-based dental implants may be challenged due to implant-related infections and inadequate osseointegration. With the development of nanotechnology, nanoscale modifications and the application of nanomaterials have become key areas of focus for research on dental implants. Surface modifications and the use of various coatings, as well as the development of the controlled release of antibiotics or proteins, have improved the osseointegration and soft-tissue integration of dental implants, as well as their antibacterial and immunomodulatory functions. This review introduces recent nano-engineering technologies and materials used in topographical modifications and surface coatings of Ti-based dental implants. These advances are discussed and detailed, including an evaluation of the evidence of their biocompatibility, toxicity, antimicrobial activities and in-vivo performances. The comparison between these attempts at nano-engineering reveals that there are still research gaps that must be addressed towards their clinical translation. For instance, customized three-dimensional printing technology and stimuli-responsive, multi-functional and time-programmable implant surfaces holds great promise to advance this field. Furthermore, long-term in vivo studies under physiological conditions are required to ensure the clinical application of nanomaterial-modified dental implants.

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“…In the third step, the degradation and desorption of chitosan in the later stage causes the release of vancomycin to slow down, and the above results can be confirmed by the experimental results shown in Figure 3 E [ 30 ]. In the reports of Swanson et al [ 61 ], Ordikhani [ 62 ] et al, Rahnamaee [ 63 ], and Liu et al [ 64 ], although different metal processes and drug-loading technologies were used, they all used chitosan or hyaluronic acid for vancomycin storage and as a medium for slow-release control. The three steps of vancomycin storage and release are similar to the above summary.…”

Section: Antibacterial Effectsmentioning

confidence: 99%

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

Gao

Zhao

et al. 2021

Nanomaterials

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Titanium implants have always been regarded as one of the gold standard treatments for orthopedic applications, but they still face challenges such as pain, bacterial infections, insufficient osseointegration, immune rejection, and difficulty in personalizing treatment in the clinic. These challenges may lead to the patients having to undergo a painful second operation, along with increased economic burden, but the use of drugs is actively solving these problems. The use of systemic drug delivery systems through oral, intravenous, and intramuscular injection of various drugs with different pharmacological properties has effectively reduced the levels of inflammation, lowered the risk of endophytic bacterial infection, and regulated the progress of bone tumor cells, processing and regulating the balance of bone metabolism around the titanium implants. However, due to the limitations of systemic drug delivery systems—such as pharmacokinetics, and the characteristics of bone tissue in the event of different forms of trauma or disease—sometimes the expected effect cannot be achieved. Meanwhile, titanium implants loaded with drugs for local administration have gradually attracted the attention of many researchers. This article reviews the latest developments in local drug delivery systems in recent years, detailing how various types of drugs cooperate with titanium implants to enhance antibacterial, antitumor, and osseointegration effects. Additionally, we summarize the improved technology of titanium implants for drug loading and the control of drug release, along with molecular mechanisms of bone regeneration and vascularization. Finally, we lay out some future prospects in this field.

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Nanofibrillated chitosan coated highly ordered titania nanotubes array/graphene nanocomposite with improved biological characters

Cited by 23 publications

References 43 publications

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

Infections @ Trauma/Orthopedic Implants: Recent Advances on Materials, Methods, and Microbes—A Mini-Review

Dental Implant Nano-Engineering: Advances, Limitations and Future Directions

Titanium Implants and Local Drug Delivery Systems Become Mutual Promoters in Orthopedic Clinics

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