Nanofiltration membrane for bio‐separation: Process‐oriented materials innovation

Abstract

Nanofiltration (NF) with advantages of high efficiency and low‐cost has attracted increasing attentions in bio‐separation. However, the large‐scale application is limited by the inferior molecular selectivity, low chemical stability and serious membrane fouling. Many efforts, thus, have been devoted in NF materials design for specific applications to enhance the separation efficiency of bio‐products and increase membrane life‐time, as well as reduce the operating cost. This review summarized the recent progress of NF applications in bio‐separation, discussed various demands for NF membrane in the bio‐products purification and corresponding material innovations, finally proposed several practical suggestions for future research, which provided directions and guidance toward further product development and process industrialization.

Recovery of Natural Polyphenols from Spinach and Orange By-Products by Pressure-Driven Membrane Processes

“…In the case of the NF270 membrane, due to the dense polymeric structure of the rejection surface layers of this membrane, contaminants easily penetrated it, resulting in an increase in the hydraulic resistance and therefore a reduction in its permeate flux at the end of the process [ 55 ]. Regarding the DURACID membrane, the sulfonation of the hydrophilic surface of this membrane improves the biocompatibility of the polymers, favoring the permeability to water and inhibiting the adhesion of biomolecules such as proteins, and thus obtaining better permeate flux [ 56 ].…”

A Novel Approach for the Development of Low-Cost Polymeric Thin-Film Nanocomposite Membranes for the Biomacromolecule Separation

“…At present, with the evolution taking place in the separation science and technology field, membrane filtration has grabbed the attention of many because membranes impart numerous benefits in terms of either saving energy or low operational cost, providing an environmentally friendly route . The separation of biomacromolecules using membrane technology depend on the kind of materials used and the properties of the proteins such as surface charges, their interactions, and the differences in the size of the proteins . The pressure-driven nanofiltration (NF) membrane has been emerging with outstanding results in the separation process, typically in the field of water desalination, , wastewater treatment, water purification, water softening, food, biotechnology, and pharmaceutical industries .…”

Enhancing the Antifouling Ability of a Polyamide Nanofiltration Membrane by Narrowing the Pore Size Distribution via One-Step Multiple Interfacial Polymerization

“…Therefore, nanofiltration membranes have received lots of interest in the field of water purification and bioproduct manufacturing because of their ability to accurately separate the targeted solutes from other components. 1,2 However, severe membrane fouling is a notorious problem commonly encountered in real applications. 3,4 The foulants existing in feeds such as proteins, polysaccharides, and natural organic matters may deposit on the membrane surface or block membrane pores.…”

“…Membrane separation has potential applications because of its low energy requirements and less environmental hazards. Therefore, nanofiltration membranes have received lots of interest in the field of water purification and bioproduct manufacturing because of their ability to accurately separate the targeted solutes from other components. , However, severe membrane fouling is a notorious problem commonly encountered in real applications. , The foulants existing in feeds such as proteins, polysaccharides, and natural organic matters may deposit on the membrane surface or block membrane pores. Meanwhile, membrane fouling results in a lower permeation flux, variable selectivity, more frequent chemical cleaning, and a shorter membrane life, which mainly limit the extensive applications of nanofiltration.…”