This article deals with Sisko fluid flow exhibiting peristaltic mechanism in an asymmetric channel with sinusoidal wave propagating down its walls. The channel walls in heat transfer process satisfy the convective conditions. The flow and heat transfer equations are modeled and non-dimensionalized. Analysis has been carried out subject to low Reynolds number and long wavelength considerations. Analytical solution is obtained by using the regular perturbation method by taking Sisko fluid parameter as a perturbed parameter. The shear-thickening and shear-thinning properties of Sisko fluid in the present nonlinear analysis are examined. Comparison is provided between Sisko fluid outcomes and viscous fluids. Velocity and temperature distributions, pressure gradient and streamline pattern are addressed with respect to different parameters of interest. Trapping and pumping processes have also been studied. As a result, the thermal analysis indicates that the implementation of a rise in a non-Newtonian parameter, the Biot numbers and Brinkman number increases the thermal stability of the liquid.