Refrigeration applications are generally based on vapor compression systems and represent a significant contribution to global climate change. While refrigeration is instrumental to the development of humanity, it is predicted that an increase in the number of refrigeration applications will worsen the issue of climate change. Hence, energy-efficient systems with a lower contribution to global warming are required. In the last years the research and development of new working fluid technologies and methodologies have provided an opportunity for the transition from vapor compression systems based on fluorine fluids to more sustainable alternatives. For instance, the potential advantages and drawbacks of hydrofluoroolefins are being investigated, and mixtures with hydrofluorocarbons are being developed to find trade-off solutions. Furthermore, the applications of hydrocarbons are being extended to installations that require a lower refrigerant charge. Lower flammability refrigerants require new flammability and risk analysis studies to determine their possible hazard. Heat and mass transfer phenomena studies are being carried out for new pure and mixed refrigerants. Ejectors are being studied to increase energy performance in particular applications. Alternative technologies based on renewable energy or solid states, such as solar cooling or magnetic refrigeration, are being developed and integrated into new processes. The integration of phase change materials and slurries is a promising new alternative. Finally, nanoparticles and nanofluids have opened an entirely new world of possibilities. The available literature on these topics is still in its early stages and these working fluids, technologies, and methodologies are not considered mature. However, there is significant potential to improve energy efficiency as well as the operation and capacity of these new approaches.