Nanofluidic devices for the separation of biomolecules

Rathnayaka, Chathurika; Amarasekara, Charuni A.; Akabirov, Khurshed; Murphy, Michael C.; Park, Sunggook; Witek, Małgorzata A.; Soper, Steven A.

doi:10.1016/j.chroma.2022.463539

Cited by 7 publications

(2 citation statements)

References 133 publications

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“…This one‐dimensional (1D) approach is used to model long, thin channels that are wide in one cross‐sectional dimension and very shallow in the other. Such wide and shallow channels are commonly employed in practice (a geometry often referred to as a nanoslit) [2, 17, 30, 31]. The nanochannel is subjected to an axial electric field along its long dimension with magnitude

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Section: Theory and Analytical Derivationsmentioning

confidence: 99%

“…Transport of electrolytes in micro/nanofluidic channels plays an important role in various technologies, including biosensors [1,2], micropumps [3], micro/nanochannel heat exchangers [4,5], and water desalination systems [6,7]. In these nanofluidic channels and nanopores, channel height is often on the same order as the thickness of its electric double layer (EDL), and electrokinetic phenomena can become highly nonlinear and very different Abbreviations: AS, atomic simulation; DE, dielectric saturation; DH, Debye-Hückel; EC, electrostatic correlation; EDL, electric double layer; MD, molecular dynamics.…”

Section: Introductionmentioning

confidence: 99%

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Analytical solutions for viscoelectric effects in electrokinetic nanochannels

Ma,

Ramachandran,

Santiago

2024

Electrophoresis

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Understanding electrokinetic transport in nanochannels and nanopores is essential for emerging biological and electrochemical applications. The viscoelectric effect is an important mechanism implicated in the increase of local viscosity due to the polarization of a solvent under a strong electric field. However, most analyses of the viscoelectric effect have been limited to numerical analyses. In this work, we present a set of analytical solutions applicable to the physical description of viscoelectric effects in nanochannel electrokinetic systems. To achieve such closed‐form solutions, we employ the Debye–Hückel approximation of small diffuse charge layer potentials compared to the thermal potential. We analyze critical parameters, including electroosmotic flow profiles, electroosmotic mobility, flow rate, and channel conductance. We compare and benchmark our analytical solutions with published predictions from numerical models. Importantly, we leverage these analytical solutions to identify essential thermophysical and nondimensional parameters that govern the behavior of these systems. We identify scaling parameters and relations among surface charge density, ionic strength, and nanochannel height.

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Section: Theory and Analytical Derivationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Analytical solutions for viscoelectric effects in electrokinetic nanochannels

Ma,

Ramachandran,

Santiago

2024

Electrophoresis

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Electrophoresis of a weakly charged dielectric fluid droplet in a cylindrical pore

Lu,

Tseng,

Chuang

et al. 2024

Electrophoresis

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Electrophoresis of a weakly charged dielectric droplet with constant surface charge density in a chargeless cylindrical pore is investigated theoretically in this study, focusing on the boundary confinement effect of the double layer, which in turn determines the ultimate motion of the droplet. A patched pseudo‐spectral method based on the Chebyshev polynomial is adopted to solve the resulting governing fundamental electrokinetic equations. Mobility reversal, among other interesting phenomena, is observed when the droplet is in a narrow cylindrical pore. No such observation was made in the corresponding motion of a rigid particle. The droplet with a thick double layer may even move against the prediction based on the Coulomb electrostatic law, for instance, a positively charged droplet may move against the electric field. The significant enhancement of the motion‐deterring double layer polarization due to the severe steric boundary confinement within a narrow cylindrical pore is found to be responsible for this seemingly peculiar phenomenon. Moreover, smaller droplets may move in the opposite direction of the larger ones. The results are useful in capillary electrophoresis involving droplets in particular and migration of droplets through narrow channels in general.

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Emergence of Microfluidic Platforms as Point of Care Diagnostics for the Detection of Plant and Foodborne Pathogens

Ameenudeen,

Hemalatha

2024

Curr. Pharmacol. Rep.

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Nanofluidic devices for the separation of biomolecules

Cited by 7 publications

References 133 publications

Analytical solutions for viscoelectric effects in electrokinetic nanochannels

Analytical solutions for viscoelectric effects in electrokinetic nanochannels

Electrophoresis of a weakly charged dielectric fluid droplet in a cylindrical pore

Emergence of Microfluidic Platforms as Point of Care Diagnostics for the Detection of Plant and Foodborne Pathogens

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