Nanoformulation of Curcuma longa Root Extract and Evaluation of Its Dissolution Potential

Abstract

Medicinal plants have been widely used for therapeutic purposes for a long time, but they have been found to have some major issues such as low water solubility and bioavailability. In the present study, the nanoformulation of Curcuma longa L. plant extract was prepared to enhance its dissolution potential and biological activities. For the formulation of the nanosuspension, an ethanolic extract of C. longa was prepared through Soxhlet extraction using the nanoformulation technique. The nanosuspensions were formulated using four different stabilizers, namely sodium lauryl sulfate (SLS), hydroxy propyl methyl cellulose (HPMC), poly(vinyl alcohol) (PVA), and polysorbate-80 (P-80). The scanning electron microscopy (SEM), polydispersity index, and ζ potential were used for characterization of the nanoformulation. Among all of these, the surfactant stabilizer SLS was found to be the best. The average particle size of the selected optimized nanosuspension was found to be 308.2 nm with a polydispersity index (PDI) value of 0.330. The ζ potential value of the optimized nanosuspension was recorded at −33.3 mV. The SEM image indicated that the particles were slightly agglomerated, which may have occurred during lyophilization of the nanosuspension. The highest dissolution rate recorded at pH = 7 was 192.32 μg/mL, which indicates pH = 7 as the most appropriate condition for the dissolution of the C. longa nanosuspension. The antioxidant, antimicrobial, and antifungal activities of the optimized nanosuspension were also determined with regard to the coarse plant extract. The study findings suggested that the nanoprecipitation approach helps in enhancing the dissolution potential and biological activities of C. longa root extract.

An Innovative Approach to a Potential Neuroprotective Sideritis scardica-Clinoptilolite Phyto-Nanocarrier: In Vitro Investigation and Evaluation

“…Both samples demonstrated a high degree of rapid release within 30 min, about 75% for ironwort and about 85% for SZ phyto-nanocarrier, reaching a maximum of 96.37% for ironwort and 99.76% for SZ phyto-nanocarrier at 60 min (Figure 12A,C). These results are in good agreement with the requirements imposed by international regulations [117].…”

“…Recent literature results have reported that the bioavailability of a drug depends on various physical characteristics of drug delivery, such as particle size, shape, and long-range structural (atomic-scale) order [117,118]. The results indicate that both samples had increased dissolution time in an acidic environment (pH 4) over time.…”

“…Herbal preparations contain numerous phytoconstituents (belonging to distinct chemical categories) in various proportions depending on different biotic and abiotic parameters (including the selected extraction procedures), which determines variations in adsorption properties and pharmacological effectiveness [113][114][115][116][117][118]. Consequently, in vivo, biopharmaceutical performance mimic and prediction for natural products is far more challenging than single-component synthetic drugs [119][120][121].…”

“…The dissolution profile of ironwort and SZ phyto-nanocarrier at two different pH values (pH 4 and pH 7) were investigated as a function of time [117,118].…”

Synthesis of novel benzopyrimido[4,5-d]azoninone analogs catalyzed by biosynthesized Ag-TiO2 core/shell magnetic nanocatalyst and assessment of their antioxidant activity

“…10 The biosynthetic scope was also extended to include biosynthesis, solvent-free synthesis, microwave-assisted synthesis, and ultrasound-assisted synthesis. 11,12 The eld of biosynthesis is rapidly growing, with many innovative new methods being developed. 13 With its many advantages over traditional methods, biosynthesis is likely to become the standard for synthesizing nanomaterials in the future.…”