Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug

Odei-Addo, Frank; Shegokar, Ranjita; Müller, Rainer H.; Levendal, Ruby‐Ann; Frost, Carminita

doi:10.1007/s13205-017-0986-0

Cited by 14 publications

(7 citation statements)

References 34 publications

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“…Under hyperglycemic condition, the nanoformulation stimulated insulin release in INS1 pancreatic β cells and elevated glucose uptake in Chang liver cells compared to the extract. Extract-loaded NPs had an average particle size of 220 nm and were stable in different storage temperatures (Odei-Addo et al, 2017). Therefore, NLCs might be a suitable candidate to be evaluated in an animal model of diabetes.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nouri

Hajialyani

Izadi

et al. 2020

Front. Bioeng. Biotechnol.

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Metabolic syndrome includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases. Plant extracts, due to their unique advantages like anti-inflammatory, antioxidant, and insulin sensitizing properties, are interesting therapeutic options to manage MetS; however, the poor solubility and low bioavailability of lipophilic bioactive components in the herbal extracts are two critical challenges. Nano-scale delivery systems are suitable to improve delivery of herbal extracts. This review, for the first time, focuses on nanoformulations of herbal extracts in MetS and related complications. Included studies showed that several forms of nano drug delivery systems such as nanoemulsions, solid lipid nanoparticles, nanobiocomposites, and green-synthesized silver, gold, and zinc oxide nanoparticles have been developed using herbal extracts. It was shown that the method of preparation and related parameters such as temperature and type of polymer are important factors affecting physicochemical stability and therapeutic activity of the final product. Many of these formulations could successfully decrease the lipid profile, inflammation, oxidative damage, and insulin resistance in in vitro and in vivo models of MetS-related complications. Further studies are still needed to confirm the safety and efficacy of these novel herbal formulations for clinical application.

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Section: Diabetes Mellitusmentioning

confidence: 99%

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nouri

Hajialyani

Izadi

et al. 2020

Front. Bioeng. Biotechnol.

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“…They present high tolerability and application in sensitive routes of administration, such as intravenous and ocular. They are obtained by high‐pressure homogenization techniques, hot or cold, ultrasound, and emulsification with solvent and microemulsion methods [19,54] …”

Section: Obtaining Nanosystemsmentioning

confidence: 99%

“…They are obtained by high-pressure homogenization techniques, hot or cold, ultrasound, and emulsification with solvent and microemulsion methods. [19,54] There are, as we can observe, ample and diversified obtaining techniques with particular methodologies, with attention to the best way of incorporating natural actives and maintaining the stability of the final product. This way, it is important to understand the importance of the techniques for therapeutic, food, and cosmetic purposes, according to the potential of the extracts of the vegetable species.…”

Section: Obtaining Nanosystemsmentioning

confidence: 99%

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

Silva

Ferreira

Soares

2023

Chemistry & Biodiversity

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Because of the increasing demand for natural products, the development of nanoformulations containing natural active ingredients requires in‐depth knowledge of the substances used, methods of obtaining, and stability profiles to ensure product quality, efficacy, and safety. Considering this, the bibliography of the last five years presented in databases (PubMed and Science Direct) was discussed in this work, discussing the study with medicinal plants to obtain active metabolites with therapeutic properties, as well as the different nano‐systems responsible for carrying these molecules. Due to the wealth of biodiversity found in the world, many species are submitted to the extraction process for several purposes. However, identifying, classifying, and quantifying the constituents of herbal matrices are crucial steps to verify their therapeutic potential. In addition, knowing the techniques of production and elaboration of nanotechnology products allows the optimization of the incorporation of herbal extracts as an innovation target. For studies to be successful, it is necessary to exhaust experimental results that guarantee the efficacy, safety, and quality of natural nanosystems, with the objective of obtaining reliable answers in nanotechnology therapy.

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“…The pharmacology of L. leonurus is well-recorded as reviewed by Mazimba (2015) [ 140 ] and Nsuala et al (2015) [ 10 ], though some notable studies include the in vitro anti-HIV activity of several South African medicinal plant extracts, of which L. leonurus was recorded to exhibit significant HIV-1 inhibition (33% reduction in HIV-1 p24, p < 0.05) [ 352 ]. Other studies have observed noteworthy anti-inflammatory and analgesic activity [ 137 ], as well as anthelmintic [ 353 , 354 ], hepatoprotective [ 137 ] and anti-diabetic activities [ 355 ]. Furthermore, the presence of marrubiin in several Lamiaceae species and the pharmacological efficacy of this terpenoid has been well documented.…”

Section: Traditional Usesmentioning

confidence: 99%

The Botanical, Chemical and Ethnobotanical Diversity of Southern African Lamiaceae

Rattray

Wyk

2021

Molecules

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The Lamiaceae is undoubtedly an important plant family, having a rich history of use that spans the globe with many species being used in folk medicine and modern industries alike. Their ability to produce aromatic volatile oils has made them valuable sources of materials in the cosmetic, culinary, and pharmaceutical industries. A thorough account of the taxonomic diversity, chemistry and ethnobotany is lacking for southern African Lamiaceae, which feature some of the region’s most notable medicinal and edible plant species. We provide a comprehensive insight into the Lamiaceae flora of southern Africa, comprising 297 species in 42 genera, 105 of which are endemic to the subcontinent. We further explore the medicinal and traditional uses, where all genera with documented uses are covered for the region. A broad review of the chemistry of southern African Lamiaceae is presented, noting that only 101 species (34%) have been investigated chemically (either their volatile oils or phytochemical characterization of secondary metabolites), thus presenting many and varied opportunities for further studies. The main aim of our study was therefore to present an up-to-date account of the botany, chemistry and traditional uses of the family in southern Africa, and to identify obvious knowledge gaps.

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Nanoformulation of Leonotis leonurus to improve its bioavailability as a potential antidiabetic drug

Cited by 14 publications

References 34 publications

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Nanotechnology Formulations Designed with Herbal Extracts and Their Therapeutic Applications – A Review

The Botanical, Chemical and Ethnobotanical Diversity of Southern African Lamiaceae

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