Nanoformulations-based advancement in the delivery of phytopharmaceuticals for skin cancer management

Yasmeen,; Iqubal, Mohammad Kashif; Khan, Mohd Ashif; Agarwal, Nidhi; Ali, Javed; Baboota, Sanjula

doi:10.1016/j.jddst.2021.102912

Cited by 10 publications

(5 citation statements)

References 134 publications

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“…With the help of this technique, doctors can see the cancer's extent and make treatment plans. One can employ quantum dots to track how well a treatment is working [ 355 ]. Researchers and medical professionals can instantly monitor the efficacy of treatments by conjugating them with certain molecules that react to modifications in the tumor microenvironment.…”

Section: Nanotechnological Approaches To Tackle Skin Cancer (Critical...mentioning

confidence: 99%

“…This would reduce the doserelated toxicity. They will manage skin cancer in the future because of the special function of phytopharmaceuticals in the treatment of skin cancer or carcinoma cancer by targeting various molecular pathways without harming other normal cells [355]. A combination approach can provide synergy which ultimately would reduce the dose of drugs and lethality involved with the currently used chemotherapeutics [356].…”

Section: Benefits Of Phytopharmaceuticalsmentioning

confidence: 99%

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Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, treatments available till date including phytocompounds, chemotherapy, radiotherapy, photothermal therapy, surgery, combination therapy, molecular targets associated with cancer growth and metastasis, and special emphasis on nanotechnology-based approaches for downregulating the deleterious disease. A detailed analysis with respect to types of nanoparticles and their scope in overcoming multidrug resistance as well as associated clinical trials has been discussed. Graphical Abstract

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Section: Nanotechnological Approaches To Tackle Skin Cancer (Critical...mentioning

confidence: 99%

Section: Benefits Of Phytopharmaceuticalsmentioning

confidence: 99%

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Hasan,

Nadaf,

Imran

et al. 2023

Mol Cancer

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“…Hence, looking into the risk-benefit ratio of drugs combination of chemotherapy and immunotherapy appears to be more rational and effective, but at the same time, drug combination increases the cost of treatment frequency of dosing and exhibits serious side effects (Yasmeen et al, 2021 ). Hence, to overcome such an issue, low-dose immunotherapeutic or chemotherapeutic drugs were initially used, but the pharmacokinetic limitation was still prevalent (Da Silva et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

“…Another advantage of using nanocarriers for combinational drug delivery is the use of a lower drug dose that results in better safety profile and the possibility of avoiding drug resistance. Moreover, the use of a nanocarrier for the dual drug delivery also helps in bypassing the drug uptake via endocytosis and exhibits superior bioavailability (Yasmeen et al, 2021 ). In conclusion, the nanoformulated combinatorial drugs (NFCDs) delivery system offers several advantages, such as synergistic effect, minimal drug resistance, controlled drug release, and superior anticancer effect with an improved safety profile as shown in Figure 3 .…”

Section: Combination Based Onconanotherapeuticsmentioning

confidence: 99%

A technical note on emerging combination approach involved in the onconanotherapeutics

Iqubal

Kaur

et al. 2022

Drug Delivery

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Cancer is the second cause of mortality worldwide, and the currently available conventional treatment approach is associated with serious side effects and poor clinical outcomes. Based on the outcome of the exploratory preclinical and clinical studies, it was found that therapeutic response increases multiple folds when anticancer drugs are used in combination. However, the conventional combination of anticancer drugs was associated with various limitations such as increased cost of treatment, systemic toxicity, drug resistance, and reduced pharmacokinetic attributes. Hence, attempts were made to formulate nanocarrier fabricated combinatorial drugs (NFCDs) to effectively manage and treat cancer. This approach offers several advantages, such as improved stability, lower drug exposure, targeted drug delivery, low side effects, and improved clinical outcome. Hence, in this review, first time, we have discussed the recent advancement and various types of nano carrier-based combinatorial drug delivery systems in a different type of cancer and highlighted the personalized combinatorial theranostic medicine as a futuristic anticancer treatment approach.

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“…Their phospholipid bilayer structure closely resembles the skin's lipid structure, promoting compatibility and reducing the likelihood of adverse reactions. This makes transfersomes an ideal carrier for drugs intended for dermatological applications [26][27][28]. Additionally, transfersomes facilitate the encapsulation of hydrophilic and lipophilic compounds alike, expanding the range of therapeutic agents that can be effectively delivered.…”

Section: Introductionmentioning

confidence: 99%

Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

Asram SAĞIROĞLU,

AYDIN

2024

jrp

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This study investigates the encapsulation of bakuchiol, a renowned compound for hyperpigmentation treatment, utilizing transfersomes as a delivery system. The transfersomes were fabricated using the thin-film hydration technique and subjected to thorough characterization across various parameters. The resulting transfersome formulation, after optimization, demonstrated notably high encapsulation efficiencies, with bakuchiol registering at 86.7±3.6%, accompanied by a narrow particle size distribution (179.9 ± 5.4 nm). In vitro release studies unveiled cumulative release percentages of 71.98±6.52% for bakuchiol over a 24-hour period. Ex vivo permeation studies further affirmed heightened retention of bakuchiol within the skin layers compared to control group. Stability assessments indicated that the optimized transfersome remained stable at 5°C for at least 90 days. These findings underscore the remarkable potential of transfersomes in facilitating the delivery of bakuchiol, offering a compelling and viable alternative for hyperpigmentation formulations.

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Nanoformulations-based advancement in the delivery of phytopharmaceuticals for skin cancer management

Cited by 10 publications

References 134 publications

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches

A technical note on emerging combination approach involved in the onconanotherapeutics

Development and evaluation of the novel topical formulation containing Bakuchiol for enhanced skin delivery

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