Nanoformulations for dermal delivery of imiquimod: The race of “soft” against “hard”

Petrová, Eliška; Chvíla, Stanislav; Balouch, Martin; Štěpánek, František; Zbytovská, Jarmila

doi:10.1016/j.ijpharm.2023.123577

International Journal of Pharmaceutics

2023

DOI: 10.1016/j.ijpharm.2023.123577

|View full text |Cite

Nanoformulations for dermal delivery of imiquimod: The race of “soft” against “hard”

Eliška Petrová,

Stanislav Chvíla,

Martin Balouch

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article5

Relationship

Self Cite0

Independent5

Authors

Journals

Cited by 5 publications

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Petrová,

Chvíla,

Štěpánek

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

The utilization of 3D printing– digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug solubility in printing resin, especially if it is predominantly composed of water. The possible solution how to ensure ideal belonging of drug and water-based printing resin is its pre-formulation in nanosuspension such as nanocrystals. This study investigates the feasibility of this approach on a resin containing nanocrystals of imiquimod (IMQ), an active used in (pre)cancerous skin conditions, well known for its problematic solubility and bioavailability. The resin blend of polyethylene glycol diacrylate and N-vinylpyrrolidone, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photoinitiator, was used, mixed with IMQ nanocrystals in water. The final microneedle-patches had 36 cylindrical microneedles arranged in a square grid, measuring approximately 600 μm in height and 500 μm in diameter. They contained 5wt% IMQ, which is equivalent to a commercially available cream. The homogeneity of IMQ distribution in the matrix was higher for nanocrystals compared to usual crystalline form. The release of IMQ from the patches was determined ex vivo in natural skin and revealed a 48% increase in efficacy for nanocrystal formulations compared to the crystalline form of IMQ. Graphical Abstract

show abstract

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Petrová,

Chvíla,

Štěpánek

et al. 2024

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers

da Silva Gomes,

Cláudia Paiva-Santos,

Veiga

et al. 2024

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy

Lopes-Nunes,

Oliveira,

Cruz

2024

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Nanoformulations for dermal delivery of imiquimod: The race of “soft” against “hard”

Cited by 5 publications

References 39 publications

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing

Beyond the adverse effects of the systemic route: Exploiting nanocarriers for the topical treatment of skin cancers

Enhanced targeted liposomal delivery of imiquimod via aptamer functionalization for head and neck cancer therapy

Contact Info

Product

Resources

About