Nanoformulations mediated metastasis brake in cancer therapy via photodynamic-enhanced ferroptosis and regional inflammation management

Huang, Jianwen; Wang, Shuai; Zhou, You; Li, Qiuxia; Yin, Jing; Zha, Dailong; Zhong, Junyang; Zhou, Wenmin; Zheng, Chengkun; Miao, Yingling; Chen, Wenjie; Xu, Chuanshan; Li, Yanli; Gong, Teng

doi:10.1016/j.cej.2022.138585

Cited by 6 publications

(7 citation statements)

References 68 publications

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“…As a result, necroptosis is also expected to be another new metal-based PSs-induced RCD. Additionally, organic-based PSs have been found to induce a 165,167,185 ferroptosis, 65,186,187 and ICD, 114,115,188 there are also necroptosis, [189][190][191][192]192 parthanatos, 193 and autophagy-dependent cell death. 194−196 These also have the potential to be new directions for the induction of novel RCDs by metal-based PSs.…”

Section: Conclusion and Future Remarksmentioning

confidence: 99%

“…Additionally, organic-based PSs have been found to induce a wider variety of RCDs than metal-based PSs. Besides apoptosis, − pyroptosis, ,, ferroptosis, ,, and ICD, ,, there are also necroptosis, − LDCD, parthanatos, and autophagy-dependent cell death. − These also have the potential to be new directions for the induction of novel RCDs by metal-based PSs.…”

Section: Conclusion and Future Remarksmentioning

confidence: 99%

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Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

2023

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Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as RCD inducers has not yet been presented. In this review, we systematically summarize the works on metal-based PSs that induce different types of RCD, including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained. At the end of each section, a summary of the reported commonalities between different metal-based PSs inducing the same RCD is emphasized, and future perspectives on metal-based PSs inducing novel forms of RCD are discussed at the end of the review. Considering the essential roles of metal-based PSs and RCD in cancer therapy, we hope that this review will provide the stage for future advances in metal-based PSs as RCD inducers.

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Section: Conclusion and Future Remarksmentioning

confidence: 99%

Section: Conclusion and Future Remarksmentioning

confidence: 99%

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

2023

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“…Another example combining antiinflammatory drug molecule sulfasalazine (SAS) with Ce6 was brought up by Huang and co‐workers to realize enhanced tumor‐killing activity and inhibited metastasis (Figure 5C,D). [ 82 ] SAS can activate programmed ferroptosis in tumor cells and suppress the migration behavior of survived cancer cells after the treatment via deactivating the proinflammatory signaling pathway nuclear‐factor kappa B (NF‐κB).…”

Section: Ce6‐based Self‐assembled Nanoparticles For Combinational The...mentioning

confidence: 99%

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Liu,

Xu,

Lyu

et al. 2023

Aggregate

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Nowadays, cancer has become the leading cause of death worldwide, driving the need for effective therapeutics to improve patient prognosis. Photodynamic therapy (PDT) has been widely applied as an antitumor modality, owing to its minimal invasiveness, localized tumor damage, and high safety profile. However, its efficacy is limited by poor stability of photosensitizers, inadequate tumor accumulation, and a complex tumor microenvironment. To overcome these challenges, extensive endeavors have been made to explore the co‐assembly of the widely used photosensitizer chlorin e6 (Ce6) with various functional small molecules to enhance pharmacodynamic activity. This review provides a comprehensive overview of current studies on Ce6‐based nanoparticles for effective PDT and precise delivery of functional molecules. The self‐assembly mechanism will be discussed in detail, with a focus on potential strategies for combinational therapy with PDT.

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“…[29] The depletion of non-enzymatic antioxidants or the inhibition of antioxidant enzymes could effectively reduce ROS resistance in cancer cells and improve PDT outcomes. [30,31] Recently, many works have focused on the intracellular ROS-resistance pathways in cancer cells, such as System xc − -GSH-GPX4 signal pathways, which play an important role in mediating cystine uptake. [32][33][34][35][36] Cystine is an oxidized form of cysteine that acts as a critical precursor for the biosynthesis of glutathione, a major intracellular antioxidant.…”

Section: Introductionmentioning

confidence: 99%

Overcoming ROS Resistance of Photodynamic Therapy with Self‐Assembled Nano‐Prodrugs for Efficient Triple‐Negative Breast Cancer

Li,

Tian,

Xie

et al. 2023

Adv Funct Materials

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Triple‐negative breast cancer (TNBC) is endowed with a highly aggressive nature that results in distant metastases and high recurrence rates, yet limited success is realized in traditional chemotherapy. Activatable photosensitizers (PSs) may provide an effective and non‐invasive strategy to induce TNBC cell death in a precise way by offering stimuli‐responsive reactive oxygen species (ROS). However, the toxicity of ROS is often mitigated and even devitalized by the instinctive behavior of ROS resistance in TNBC cells. To address this issue, herein a small molecular self‐assembly nano‐prodrug is presented to co‐deliver an activatable PS and ROS resistance inhibitor. In TNBC cells, the overexpressed glutathione can disassemble the nano‐prodrug, thereby releasing ROS resistance inhibitor and activating the PS for photodynamic therapy and fluorescence imaging. A hybrid membrane coating‐assisted nanoparticle formation strategy is further demonstrated for efficient inhibition of tumor growth and distant metastases on both subcutaneous and orthotopic TNBC mice models.

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Nanoformulations mediated metastasis brake in cancer therapy via photodynamic-enhanced ferroptosis and regional inflammation management

Cited by 6 publications

References 68 publications

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Overcoming ROS Resistance of Photodynamic Therapy with Self‐Assembled Nano‐Prodrugs for Efficient Triple‐Negative Breast Cancer

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