Nanoformulations of Drugs Based on Biodegradable Lactide Copolymers with Various Molecular Structures and Architectures

Abstract

Modern pharmaceutics are actively developing towards the design of targeted drugs. The development of selectively acting formulations requires the creation of smart delivery systems based on carriers that would first find the target cells and enter them and then release the active substance locally. Nanoparticles of biocompatible and biodegradable polymers can be effectively used as such carriers. Flexible regulation of the molecular structure and architecture of polymers, as well as the modification of nanoparticles with vector molecules, allows one to construct carrier particles for the development of nanoformulations for active agents of various nature. This review presents the main approaches to the design of nanoformulations for targeted delivery, describes the methods for the preparation and study of nanoparticles based on hydrophobic and amphiphilic biodegradable lactide polymers, and discusses the effect of the molecular structure and preparation conditions on the characteristics of nanoparticles in detail. Some results of research in this area of the Kurchatov complex of NBIСS nature-like technologies are also presented.

Highly Stable Docetaxel-Loaded Nanoparticles Based on Poly(D,L-lactide)-b-Poly(ethylene glycol) for Cancer Treatment: Preparation, Characterization, and In Vitro Cytotoxicity Studies

“…4 Diameter of block copolymer NPs evaluated from TEM images. 5 The value of core-corona interface area per one tethered PEG chain estimated from TEM data. 6 The As one can see from Table 3, an increase of n value from 680 to 1230 in the P(D,L)LA n -b-PEG 113 copolymers resulted in an enhancement of the (D h ) 0 value of the particles that was in accordance with previous reports [29,45].…”

“…In recent decades, design and development of various nanosized drug delivery systems (DDSs) based on inorganic nanoparticles [ 1 ], liposomes [ 2 , 3 , 4 ], polymeric nanoparticles (PNPs) [ 5 , 6 , 7 ], dendrimers [ 8 ], etc., for treatment of different diseases has gained great interest. The use of nanocarriers can improve the delivery of poorly soluble drugs in water, provide targeted delivery and controlled release of drugs, and increase their stability and bioavailability.…”

The Role of Integrated Approach in the Determination of Nanoparticle Sizes in Dispersions

“…[1][2][3]. Moreover, NPs are applied in biomedicine as diagnostic agents [4], agents for photodynamic therapy of cancerous tumors [5], targeted drug delivery systems [6][7][8], etc.…”

Raman Study of Block Copolymers of Methyl Ethylene Phosphate with Caprolactone and L-lactide

“…Besides production of various ecologically friendly consumer goods, biodegradable and biocompatible polymers have great potential in the state-of-the-art biomedical and pharmaceutical applications, such as creating of the nanocarriers for targeted drug delivery with controlled release of active substances, implants as well as functional coatings on implants, scaffolds for tissue engineering, suture materials, etc. [1,2]. Such polymer items as well as products of their degradation should be non-toxic, degrade in vivo in human organism in particular time and with particular rate (with particular profile of degradation), and the products of the degradation should be eliminated from the body without any harmful impact for organism.…”

“…Amphiphilic block copolymers of methyl ethylene phosphate (MeOEP) with caprolactone (CL) and L-lactide (LA) are very promising for biomedical applications due to the possibility of varying their physical and chemical properties, including the degradation profile, in wide range by alteration of the conditions of synthesis or post-treatment. The presence of hydrophilic poly(methyl ethylene phosphate) (PMeOEP) and hydrophobic polycaprolactone (PCL) or poly(L-lactide) (PLA) parts makes possible the self-organization of the copolymer molecules in nanostructures of various architectures [1][2][3]. Since the structure of a polymer material determines its properties, it is very important to have an informative and fast method of evaluating the most important structural characteristics of polymer items without any preparation of samples for analysis, because such preparation can affect the sample structure.…”