Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection

Lim, Dong Kwon; Jeon, Ki Seok; Kim, Hyung Min; Nam, Jwa Min; Suh, Yung Doug

doi:10.1038/nmat2596

Cited by 1,112 publications

(641 citation statements)

References 50 publications

Supporting

Mentioning

627

Contrasting

Unclassified

Order By: Relevance

“…An apparent increase in the SERS intensity was thus observed during the NP growth process. 44 However, the model proposed in our experiment (Model 3) was different from the former two, in which the SERS intensity was not as sensitive to the variation of mSiO 2 thickness ( Figure S10c, Supporting Information). In our case, Raman reporters could be adsorbed and distributed in the entire volume of mSiO 2 in a three-dimensional manner, from close to the AuNR surface to the outer surface of the mSiO 2 shell.…”

Section: Acs Applied Materials and Interfacescontrasting

confidence: 56%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

ABSTRACT:The Raman enhancing ability of noble metal nanoparticles (NPs) is an important factor for surface enhanced Raman scattering (SERS) substrate screening, which is generally evaluated by simply mixing as-prepared NPs with Raman reporters for Raman signal measurements. This method usually leads to incredible results because of the NP surface coverage nonuniformity and reporter-induced NP aggregation. Moreover, it cannot realize in situ, continuous SERS characterization. Herein, we proposed a dynamic SERS monitoring strategy for NPs with precisely tuned structures based on a simplified spatially confined NP growth method. Gold nanorod (AuNR) seed NPs were coated with a mesoporous silica (mSiO 2 ) shell. The permeability of mSiO 2 for both reactive species and Raman reporters rendered the silver overcoating reaction and SERS indication of NP growth. Additionally, the mSiO 2 coating ensured monodisperse NP growth in a Raman reporter-rich reaction system. Moreover, "elastic" features of mSiO 2 were observed for the first time, which is crucial for holding the growing NP without breakage. This feature makes the mSiO 2 coating adhere to metal NPs throughout the growing process, providing a stable Raman reporter distribution microenvironment near the NPs and ensuring that the substrate's SERS ability comparison is accurate. Three types of NPs, i.e., core−shell Au@AgNR@mSiO 2 , Au@AuNR@mSiO 2 , and yolk−shell Au@void@AuNR@mSiO 2 NPs, were synthesized via core−shell overgrowth and galvanic replacement methods, showing the versatility of the approach. The living cell SERS labeling ability of Au@AgNR@mSiO 2 -based tags was also demonstrated. This strategy addresses the problems of multiple batch NP preparation, aggregation, and surface adsorption differentiation, which is a breakthrough for the dynamic comparison of SERS ability of metal NPs with precisely tuned structures and optical properties.

show abstract

Section: Acs Applied Materials and Interfacescontrasting

confidence: 56%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…The interaction between a dye molecule and a particle dimer linked by DNA was already discussed in the literature but inhomogeneous samples prevented a statistical analysis 15 or required atomic force microscopy to correlate nanostructure geometry and Raman scattering properties 16 . To obtain homogeneous samples of SM-featuring AuNP dimers, we use electrophoresis to purify gold particles conjugated preferentially to one DNA strand 17 and, after hybridization of complementary sequences, AuNP dimers linked by a single double strand 18 .…”

Section: Dna-driven Nanoparticle Assemblymentioning

confidence: 99%

Accelerated single photon emission from dye molecule-driven nanoantennas assembled on DNA

et al. 2012

View full text Add to dashboard Cite

A photon interacts efficiently with an atom when its frequency corresponds exactly to the energy between two eigenstates. But at the nanoscale, homogeneous and inhomogeneous broadenings strongly hinder the ability of solid-state systems to absorb, scatter or emit light. By compensating the impedance mismatch between visible wavelengths and nanometre-sized objects, optical antennas can enhance light-matter interactions over a broad frequency range. Here we use a DnA template to introduce a single dye molecule in gold particle dimers that act as antennas for light with spontaneous emission rates enhanced by up to two orders of magnitude and single photon emission statistics. Quantitative agreement between measured rate enhancements and theoretical calculations indicate a nanometre control over the emitterparticle position while 10 billion copies of the target geometry are synthesized in parallel. optical antennas can thus tune efficiently the photo-physical properties of nano-objects by precisely engineering their electromagnetic environment.

show abstract

“…Surfaceenhanced Raman scattering (SERS) [1][2][3] has advanced to the detection limit of individual resonant molecules when the molecule is closely associated with the nanoscale junction between chemically fabricated nanoparticles [4][5][6][7][8][9][10][11][12] . Here two enhancement mechanisms are at play: the enhanced Raman cross-section of a molecule when the excitation laser is resonant with an electronic excitation of the molecule; and the extremely large local electromagnetic (EM) field enhancement generated by optically exciting the collective plasmon mode of the two closely adjacent nanoparticles.…”

mentioning

confidence: 99%

Coherent anti-Stokes Raman scattering with single-molecule sensitivity using a plasmonic Fano resonance

et al. 2014

View full text Add to dashboard Cite

Plasmonic nanostructures are of particular interest as substrates for the spectroscopic detection and identification of individual molecules. Single-molecule sensitivity Raman detection has been achieved by combining resonant molecular excitation with large electromagnetic field enhancements experienced by a molecule associated with an interparticle junction. Detection of molecules with extremely small Raman cross-sections (B10 À 30 cm 2 sr À 1 ), however, has remained elusive. Here we show that coherent anti-Stokes Raman spectroscopy (CARS), a nonlinear spectroscopy of great utility and potential for molecular sensing, can be used to obtain single-molecule detection sensitivity, by exploiting the unique light harvesting properties of plasmonic Fano resonances. The CARS signal is enhanced by B11 orders of magnitude relative to spontaneous Raman scattering, enabling the detection of single molecules, which is verified using a statistically rigorous bi-analyte method. This approach combines unprecedented single-molecule spectral sensitivity with plasmonic substrates that can be fabricated using top-down lithographic strategies.

show abstract

Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection

Cited by 1,112 publications

References 50 publications

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Accelerated single photon emission from dye molecule-driven nanoantennas assembled on DNA

Coherent anti-Stokes Raman scattering with single-molecule sensitivity using a plasmonic Fano resonance

Contact Info

Product

Resources

About