Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection

Abstract

The human skin is a recurring target of external aggressions, such as UV radiation, leading to exacerbation of the aging process and the occurrence of skin diseases, such as cancer. Hence, preventive measures should be taken to protect it against these aggressions, consequently decreasing the chance of disease development. In the present study, a topical xanthan gum nanogel containing gamma-oryzanol-loaded nanostructured lipid carriers (NLCs) and nanosized UV filters TiO2 and methylene bis-benzotriazolyl tetramethylbutylphenol (MBBT) was developed to assess their synergistic potential in having multifunctional skin beneficial properties. The developed NLCs contained the natural-based solid lipids shea butter and beeswax, liquid lipid carrot seed oil, and the potent antioxidant gamma-oryzanol, with an optimum particle size for topical application (<150 nm), good homogeneity (PDI = 0.216), high zeta potential (−34.9 mV), suitable pH value (6), good physical stability, high encapsulation efficiency (90%), and controlled release. The final formulation, a nanogel containing the developed NLCs and the nano UV filters, showed high long-term storage stability and high photoprotection ability (SPF = 34) and resulted in no skin irritation or sensitization (rat model). Hence, the developed formulation showed good skin protection and compatibility, demonstrating promise as a new platform for the future generation of natural-based cosmeceuticals.

Exploring Nanocarriers as Treatment Modalities for Skin Cancer

“…Dendrimers made of dendritic polyglycerol (dPG) were employed to create hydrophilic and thermo-responsive three-dimensional cross-linked nanogels that let small and big molecules penetrate SC and concentrate in hair follicles [221]. Badalkhani et al [222] formulated γ-oryzanol-loaded NLCs and nanosized UV filters TiO 2 to evaluate the synergistic potential for skin protection against diseases such as cancer. Studies have shown that nanogel loaded with NLCs and nano UV filters had excellent long-term storage stability and photoprotection capabilities, which might be useful for protection against UV-generated skin cancer.…”

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

“…The findings revealed even further promise for the usability of GO as a means of transportation for effective delivery to reduce skin irritation and skin neoplasia and improve skin-aging protection and wrinkle improvement. The semi-purified rice bran extracts (GO being one of them) formulated into topical creams and gels not only stimulated the proliferation of human fibroblasts and inhibited MMP-2 activity, but they also improved skin attributes such as hydration, pigmentation, thickness, and roughness, and skin elasticity [119,122]. These results enhance the understanding of topical dermatological products that can be used to reduce photoaging and skin texture; however, further studies would benefit an adequate vehicle and form, such as gels and creams.…”