“Nanogels as drug carriers – Introduction, chemical aspects, release mechanisms and potential applications”

Shah, Saurabh; Rangaraj, Nagarjun; Laxmikeshav, Kritika; Sampathi, Sunitha

doi:10.1016/j.ijpharm.2020.119268

Cited by 88 publications

(58 citation statements)

References 164 publications

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“…Because amphiphilic biomaterial is sensitive to H 2 O 2 , the concentration of hydrogen peroxide can be reduced at the ischaemic site, limiting damage to the body. The H 2 O 2sensitive amphiphilic biomaterial of the present invention is used as a drug carrier to meet the needs of extended circulation and targeted therapy (Shah et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

ROS-Sensitive Nanoparticles Co-delivering Dexamethasone and CDMP-1 for the Treatment of Osteoarthritis Through Chondrogenic Differentiation Induction and Inflammation Inhibition

Cheng

et al. 2021

Front. Bioeng. Biotechnol.

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Objective: Osteoarthritis (OA) is a common subtype of arthritis. To date, treatment of OA focuses primarily on alleviating pain and improving joint function. The lack of a vascular system within synovial joints and the rapid removal of agents due to synovial exchange hinder continuous delivery of OA drugs. However, these obstacles are being addressed by promising nanoscale drugs.Methods: We synthesize and assemble a hydrogen peroxide [H2O2, belongs to the category of active oxygen species (ROS)]-sensitive nanomicelle, which is loaded with the anti-inflammation drug dexamethasone and chondrogenic differentiation factor cartilage-derivedmor-phogeneticprotein-1. The micelle can induce bone marrow mesenchymal stem cells to repair cartilage while inhibiting joint inflammation.Results: The prepared nanoparticles were of uniform size and displayed an obvious core-shell structure. Under H2O2 stimulation, the shell layer could be removed gradually. The drug-loaded micelle effectively inhibited proliferation of activated macrophages, induced macrophage apoptosis with an anti-inflammatory effect, and caused the BMSCs to differentiate into chondrocytes.Conclusion: This work provides an experimental and theoretical basis for further development of a drug-loaded micelle in the healing of osteoarthritis.

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Section: Resultsmentioning

confidence: 99%

ROS-Sensitive Nanoparticles Co-delivering Dexamethasone and CDMP-1 for the Treatment of Osteoarthritis Through Chondrogenic Differentiation Induction and Inflammation Inhibition

Cheng

et al. 2021

Front. Bioeng. Biotechnol.

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“…When the main force acting on drug‐releasing corresponds to the amount of residual drug on the platform, that is the release profile is guided by drug concentration, the first‐order model should be used (Manadas et al, 2002). The Higuchi model considers Fick's diffusion law and may be applied to poor solubility drugs on porous drug delivery systems (Higuchi, 1963; Shah et al, 2020). However, this model neglects the erosion or swelling processes of the drug platform.…”

Section: Resultsmentioning

confidence: 99%

Gelatin/dextran‐based hydrogel cross‐linked by Diels–Alder click chemistry: the swelling and potassium diclofenac releasing

et al. 2020

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drogels could be obtained from a wide variety of materials, since a natural source to synthetic ones, being applied in food, agronomy and biomedicine (Hoffman, 2012). The applications in the biomedicine field are focus on scaffolds for tissue engineering (Bai et al., 2018), cellular immobilization (Bodenberger et al., 2017) and drug delivery systems (Pulickal et al., 2018). In the last decade, several classical organic reactions have been revisited and applied as cross-linking agents on polymer science. These reactions were generically named as click reactions due to its high reactivity and selectivity, and because it is conducted under mild conditions (Such et al., 2012). The bioorthogonality of a click reaction allows the encapsulation of bioactive molecules without causing cytotoxicity. The absence of catalysts and the formation of sub-products make these reactions an important tool to overcome the problems associated with toxicities of chemically cross-linked hydrogels (

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“… Nanosystem Advantages Disadvantages Reference Nanoemulsions Biocompatibility Increased permeability and biodistribution Great versatility of use High surfactant/co-surfactant concentration High production cost High storage cost [45] Microemulsions Biocompatibility Increased permeability and biodistribution Great versatility of use Reduces drug degradation Form spontaneously Remarkably high surfactant/co-surfactant concentration May present toxicity due to surfactant concentration Sensitive to temperature and salinity changes [46] Liposomes Biocompatibility and biodegradability Good permeability Increased drug efficacy High production cost Drug leakage Phospholipids may undergo oxidation and hydrolysis Sensitive to osmosis Inadequate stability [47] Nanogels Tunable Size Ease of Preparation Swelling Biocompatibility Stimuli responsiveness (temperature, pH, light, biological agent, etc. ) Partial drug load and suboptimal kinetic release Immunogenic when interact with serum proteins Adverse effects may occur due to the presence of surfactant and/or monomers in the matrix [48] Micelles Increased drug solubility Low toxicity Prolonged drug circulation Low stability in the blood stream Drug leakage [49] Nanoparticles Versatility Easy customization and functionalization Easy cell uptake Great permeability Controlled release …”

Section: Nanotechnological Approaches To Improve Curcumin Properties Against Sars-cov-2mentioning

confidence: 99%

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?

Dourado

Freire

Pereira

et al. 2021

Biomedicine & Pharmacotherapy

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The COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the infection pathways. Moreover, the use of curcumin-loaded nanocarriers for increasing its bioavailability and therapeutic efficiency was highlighted. Additionally, the potential of the nanostructured systems by themselves and their synergic action with curcumin on molecular targets for viral infections have been explored. Finally, a viewpoint of the studies that need to be carried out to implant curcumin as a treatment for COVID-19 was addressed.

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“Nanogels as drug carriers – Introduction, chemical aspects, release mechanisms and potential applications”

Cited by 88 publications

References 164 publications

ROS-Sensitive Nanoparticles Co-delivering Dexamethasone and CDMP-1 for the Treatment of Osteoarthritis Through Chondrogenic Differentiation Induction and Inflammation Inhibition

ROS-Sensitive Nanoparticles Co-delivering Dexamethasone and CDMP-1 for the Treatment of Osteoarthritis Through Chondrogenic Differentiation Induction and Inflammation Inhibition

Gelatin/dextran‐based hydrogel cross‐linked by Diels–Alder click chemistry: the swelling and potassium diclofenac releasing

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?

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