nanoGold and µGold inhibit autoimmune inflammation: a review

Danscher, Gorm; Rasmussen, Sten

doi:10.1007/s00418-023-02182-9

Cited by 6 publications

(5 citation statements)

References 53 publications

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“…The distribution of gold particles in the body varies depending on their size and route of administration [ 35 ]. Gold nanoparticles are used as contrast agents for X-ray and computed tomography scans, drug delivery and cancer therapy, and as carriers for therapeutic agents or as radiation enhancers.…”

Section: Discussionmentioning

confidence: 99%

“…It is general knowledge that gold nanoparticles will enter an unknown multitude of cells, which might make long-term treatment problematic. Preclinical studies suggest that macrophages phagocytose gold nanoparticles intracellularly that oxidize in the lysosomes [ 35 ]. The macrophages remove the gold nanoparticles from the tissue as these cells move away over time.…”

Section: Discussionmentioning

confidence: 99%

“…Gold microparticles larger than 20 microns are too big for the macrophages to engulf or remove [ 35 ]. Therefore, the gold microparticles dissolve slowly by macrophages through dissolucytosis.…”

Section: Discussionmentioning

confidence: 99%

“…Gold ions released from gold microparticles are a purely local process that slowly, andcontinuously produces local pharmaceutical levels of active gold ions into the intercellular space [ 4 ]. The use of gold microparticles, therefore, is considered a safe technique [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis

Rasmussen,

Petersen,

Aboo

et al. 2024

BMC Musculoskelet Disord

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Background Recently, in an open pilot study, we found up to two years, a potential pain-relieving effect of intra-articular gold micro-particles using the patient’s synovial fluid for patients with knee osteoarthritis (KOA). During the study the excluded group of patients, due to multisite pain, co-morbidities, and other exclusion criteria., received intra-articular gold micro-particles using hyaluronic acid,. We aimed to identify if pre-treatment characteristics influence the global outcome two years after intra-articular treatment for painful KOA with gold microparticles using hyaluronic acid. Methods Using hyaluronic acid as the carrier, 136 patients with KOA received intraarticular injections with 20 mg gold microparticles (72.000 particles, 20–40 μm in diameter). In the analysis, we included the Global Rating of Change Scale, Pain Detect Questionnaire (PDQ), Body Mass Index (BMI), and Kellgren & Lawrence score at the inclusion, Western Ontario, and McMaster Universities Osteoarthritis Index (WOMAC) sub-scores for pain, stiffness, and function at inclusion and two years. Results On the Global Rating Change Scale, 69.1% of patients reported a positive effect, 28.7% no effect, and 2.2% worse. PDQ and the three WOMAC subscores all improved at two years of follow-up. PDQ ≥ 13 (P = 0.028), BMI (P = 0.022) and Kellgren & Lawrence grade 4 (P = 0.028) at inclusion reduced the effect with a minor odds ratio compared to the baseline effect of treatment (P = 0.025). WOMAC subscores at inclusion did not influence the outcome (P > 0.5). Conclusions Severe osteoarthritis, obesity, and neuropathic pain, reduced the effect of intra-articular gold microparticles for knee OA. Trial registration The study followed the principles of the Declaration of Helsinki and was approved by the local ethics committee of the North Denmark Region by 27/07/2016 (N-20,160,045). The regional data protection agency approved the project by 06/07/2016 (2008-58-0028, ID 2016 − 116) and registered in ClinicalTrial.Gov by 04/01/2018 (NCT03389906).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis

Rasmussen,

Petersen,

Aboo

et al. 2024

BMC Musculoskelet Disord

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“…The anti-inflammatory properties of gold compounds manifest through their ability to modulate cytokine responses. This complex interaction involves the intricate regulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6) [7][8][9][10]. Understanding the nuances of gold-induced cytokine responses is paramount for unraveling the full therapeutic potential of these compounds.…”

Section: Introductionmentioning

confidence: 99%

GOLD-Induced Cytokine (GOLDIC): A Critical Review of Its Properties, Synthesis, and Biomedical Applications

Yadav,

Rawal,

Jeyaraman

et al. 2024

Cureus

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This narrative review examines the intricate landscape of gold-induced cytokine responses, delving into the anti-inflammatory and immune-modulating properties of gold compounds, with a primary focus on their application in treating rheumatoid arthritis and other autoimmune conditions. Utilizing a comprehensive search strategy across major scientific databases, we identified and analyzed a diverse range of studies published within the last two decades. The aim of this review is to provide a nuanced understanding of the current state of knowledge, addressing key questions regarding the mechanisms by which gold compounds modulate cytokine responses and their clinical implications. Our review encompasses an in-depth exploration of the anti-inflammatory effects of gold compounds, emphasizing their impact on pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin 1β (IL-1β), and interleukin 6 (IL-6). Moreover, we investigate the lesser-explored terrain of immune modulation, shedding light on the ability of gold compounds to influence anti-inflammatory cytokines, notably interleukin 10 (IL-10). Through an extensive analysis of the literature, we unravel the multifaceted mechanisms underlying gold-induced cytokine responses, including the inhibition of nuclear factor kappa B (NF-κB) signaling and interference with janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways. In exploring the clinical applications of gold-induced cytokine modulation, we synthesize findings from relevant studies, elucidating the potential of gold compounds as therapeutic agents. However, challenges such as variability in formulations and diverse cytokine assessment methods are discussed, emphasizing the need for standardization in both research and clinical settings. Looking ahead, our scoping review identifies key unanswered questions and proposes future directions for research in this domain. We discuss emerging therapeutic strategies, considering the integration of gold compounds with other modalities to optimize treatment outcomes. This comprehensive review serves as a foundational resource for researchers, clinicians, and policymakers seeking a nuanced understanding of gold-induced cytokine responses, paving the way for further advancements in this critical area of study.

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In focus in HCB

Taatjes

Roth

2023

Histochem Cell Biol

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nanoGold and µGold inhibit autoimmune inflammation: a review

Cited by 6 publications

References 53 publications

Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis

Intra-articular injection of gold micro-particles with hyaluronic acid for painful knee osteoarthritis

GOLD-Induced Cytokine (GOLDIC): A Critical Review of Its Properties, Synthesis, and Biomedical Applications

In focus in HCB

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