Nanogold – Biological effects and occupational exposure levels

Świdwińska-Gajewska, Anna Maria; Czerczak, Sławomir

doi:10.13075/mp.5893.00538

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…Due to their unique electronic and optical features, gold nanoparticles (AuNPs) have been used for biomarker detection, drug and gene delivery, molecular imaging and photothermal/photodynamic treatment (Boisselier & Astruc, 2009 ; Chen et al, 2007 ; Huang et al, 2007 ; Podsiadlo et al, 2008 ). Accordingly, substantial attention has been paid to the biological effects, toxicity and pharmacokinetics of AuNPs and their interactions with proteins and cells (Świdwińska-Gajewska & Czerczak, 2017 ; Feliu et al, 2016 ; Hornos Carneiro & Barbosa Jr., 2016 ; Wang et al, 2015 ; Araújo et al, 2015 ). Exposure to nanoparticles in pregnancy carries additional risks due to the potential for fetal exposure and teratogenesis or developmental distrurbances; hence, there are growing concerns regarding potential hazards resulting from exposure to nanosized materials in pregnancy (Li et al, 2014 ; Ema et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

“…A systematic study of the impact of NPs, including AuNPs, on fetal development at different stages of mammalian pregnancy has not yet been carried out. Most studies regarding developmental safety of NPs are focused on mid-term and late pregnancy (Świdwińska-Gajewska & Czerczak, 2017 ; Rattanapinyopituk et al, 2014 ; Balansky et al, 2013 ), namely, the second and third trimester of human pregnancy. Our previous studies found that tail vein injection of AuNPs (0.9 μg Au/g body weight) to pregnant mice from GD5.5 to GD13.5 did not affect fetal survival and offspring health (Yang et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Yang

et al. 2018

Mol Med

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BackgroundGold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuNPs maternal exposure at different gestational ages on fetal survival and development, as well as the potential mechanism of AuNPs affecting embryos and fetuses.MethodsThirty nm polyethylene glycol (PEG)-coated AuNPs (A30) were administered to pregnant mice via intravenous injection (5 μg Au/g body weight) over three days at either early or late pregnancy. Fetal abortion rate and morphological development in E16.5 were then detected in detail. The pregnant mice physiological states with A30 exposure were examined by biochemical, histological or imaging methods; and materno-fetal distribution of gold elements was assayed by electron microscopy and mass spectrometry. Murine embryonic stem cells derived embryoid-bodies or neuroectodermal cells were treated with A30 (0.0025 to 0.25 μg Au/mL) to examine A30 effects on expression levels of the germ differentiation marker genes. Tukey’s method was used for statistical analysis.ResultsExposure to A30 during early (A30E) but not late (A30L) pregnancy caused a high abortion rate (53.5%), lower fetal survival rate and abnormal decidualization compared with non-exposed counterparts. The developmental damage caused by A30 followed an “all-or-nothing” pattern, as the non-aborted fetuses developed normally and pregnancies maintained normal endocrine values. A30 caused minor impairment of liver and kidney function of A30E but not A30L mice. TEM imaging of fetal tissue sections confirmed the transfer of A30 into fetal brain and live as aggregates. qPCR assays showed A30 suppressed the expression of ectodermal, but not mesodermal and endodermal differentiation markers.ConclusionsThese results illustrate that maternal A30 exposure in early pregnant results in A30 transfer into embryonic tissues, inhibiting ectodermal differentiation of embryonic stem cells, leading to abnormal embryonic development and abortion. While exposure to A30 during late pregnancy had little or no impact on dams and fetuses. These findings suggest the safety of biomedical applications employing AuNPs during pregnancy is strongly influenced by fetal maturity and gestational age at exposure and provide the clues for AuNPs safe application period in pregnancy.Electronic supplementary materialThe online version of this article (10.1186/s10020-018-0061-2) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Yang

et al. 2018

Mol Med

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“…The addition of Ca increases the hardness of alloys, which is related to precipitation hardening. Precious metals, for example, silver, cause the formation of a passive layer, improving corrosion resistance, or gold, which improves corrosion resistance and increases strength and hardness [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. …”

Section: Introductionmentioning

confidence: 99%

Influence of Milling Time on Phase Composition and Product Structure of Mg-Zn-Ca-Ag Alloys Obtained by Mechanical Synthesis

Lesz

Karolus²,

Gabryś³

et al. 2022

Materials

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Magnesium-based alloys are widely used in the construction of automotive, aviation, and medical applications. The solutions presently used for the production of biodegradable materials are characterized by considerable energy consumption and limitations resulting from the use of different devices and technologies. The proposed material is easier to manufacture due to mechanical alloying (MA). Thanks to the MA process, it is possible to carefully tailor the desired chemical composition and microstructure. There are many parameters that can be modified during synthesis in order to obtain an alloy with the desired microstructure and specific expected alloy properties. The duration of grinding of the alloy, the size and number of balls, and the protective atmosphere have a great influence on the process of mechanical alloying and the properties of the obtained products. So, the aim of this work was to determine the influence of milling time on the phase composition and structure of Mg-based alloy synthesis products. The tested samples were milled for 5, 8, 13, 20, 30, 50, and 70 h. X-ray diffraction analysis (XRD) and scanning electron microscopy studies (SEM) with energy-dispersive spectroscopy (EDS) were performed to obtain the powder morphology and chemical composition of Mg66−xZn30Ca4Agx (where x = 1, 2) powders. Structure characterization based on the Rietveld refinement and crystallite size determination based on the Williamson–Hall theory of milling products were also carried out.

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Nanogold – Biological effects and occupational exposure levels

Cited by 2 publications

References 36 publications

Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Influence of Milling Time on Phase Composition and Product Structure of Mg-Zn-Ca-Ag Alloys Obtained by Mechanical Synthesis

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