Nanohybrids for controlled antibiotic release in topical applications

Tammaro, Loredana; Costantino, U.; Bolognese, Adele; Sammartino, Gilberto; Marenzi, Gaetano; Calignano, Antonio; Tetè, Stefano; Mastrangelo, Filiberto; Califano, Luigi; Vittoria, Vittoria

doi:10.1016/j.ijantimicag.2006.11.019

Cited by 76 publications

(51 citation statements)

References 23 publications

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“…As in previous cases [23,26] it can be suggested that the first stage is due to the drug anchored in the inorganic lamellae laying on the surface of the fibers. In this case the release time is dependent only on the ionic exchange reaction time, that is very rapid and is completed in 1 hour.…”

Section: Diclofenac Releasesupporting

confidence: 52%

“…These charges are balanced by interlayered hydrated anions, resulting in a multilayer of alternating host layers and gallery anions [19][20][21]. Using ion exchange reaction, many novel complexes may be synthesized, and actually anti-inflammatory, antibiotics, plant growth regulators, and others have been incorporated into LDHs, obtaining nanohybrids that can slowly release the active molecules [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Encapsulation of Diclofenac Molecules into Poly(ε‐Caprolactone) Electrospun Fibers for Delivery Protection

Tammaro

Russo

Vittoria

2009

Journal of Nanomaterials

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Mg-Al Hydrotalcite-like clay (LDH) intercalated with diclofenac anions (HTlc-DIC) was introduced into poly(ε-caprolactone) (PCL) in different concentrations by the electrospinning technique, and mats of nonwoven fibers were obtained and compared to the pristine pure electrospun PCL. The fibers, characterized by X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry, show an exfoliated clay structure up to 3 wt%, a good thermal stability of the diclofenac molecules and a crystallinity of PCL comparable to the pure polymer. The scanning electron microscopy revealed electrospun PCL and PCL composite fibers diameters ranging between 500 nm to 3.0 μm and a generally uniform thickness along the fibers. As the results suggested the in vitro drug release from the composite fibers is remarkably slower than the release from the corresponding control spun solutions of PCL and diclofenac sodium salt. Thus, HTlc-DIC/PCL fibrous membranes can be used as an antinflammatory scaffold for tissue engineering.

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Section: Diclofenac Releasesupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Encapsulation of Diclofenac Molecules into Poly(ε‐Caprolactone) Electrospun Fibers for Delivery Protection

Tammaro

Russo

Vittoria

2009

Journal of Nanomaterials

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“…The calcinationreconstruction technique of LDH was used to prepare advanced nanocomposite materials of different anions. c-Anion-exchange property, this property was used to construct efficient bionanocomposites compounds of nucleosides Lotsch et al, 2001), DNA (Minagawa et al, 2009;Xu et al, 2007), amino acids (Aisawa at al., 2006;Ajat et al, 2008;Chen et al, 2009;Reinholdt & Kirkpatrick, 2006;Wei et al, 2007) fatty acids (Nhlapo et al, 2008), sugars (Aisawa et al, 2003), drugs (Ladewig et al, 2009;Li et al, 2009;Tammaro et al, 2007;Trikeriotis & Ghanotakis, 2007;Xia et al, 2008;Zhang et al, 2009aZhang et al, , 2009b and vitamins Hwang et al, 2001;Tronto et al, 2004), through an anion-exchange mechanism of the interlayer anion of the original LDH. The exchange capacity of LDH was found to depend on the interlayer anion type.…”

Section: Properties Of Ldhmentioning

confidence: 99%

Versatile Nanocomposite Formulation System of Non-Steroidal Anti-Inflammatory Drugs of the Arylalkanoic Acids

Berber¹,

Hafez²,

Minagawa³

et al. 2011

Advances in Nanocomposite Technology

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“…Tammaro et al 76 publicaram um trabalho sobre possíveis aplicações do antibiótico succinato de cloranfenicol intercalado em HDL na liberação sustentada transdérmica, quando incorporado em um polímero (policaprolactona) biocompatível e biodegradável. Segundo os autores, o efeito local da droga evita a administração de altas doses ao paciente, diminuindo efeitos colaterais do fármaco.…”

Section: Figura 9 Imagens De Microscopia Confocal Do Núcleo De Célulunclassified

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

Cunha¹,

Ferreira²,

Constantino³

et al. 2010

Quím. Nova

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Recebido em 11/12/08; aceito em 1/7/09; publicado na web em 27/11/09 LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST. Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.Keywords: layered double hydroxides; inorganic carriers; drug release. INTRODUÇÃOO desenvolvimento de materiais híbridos é um campo de pesquisa que vem apresentando um desenvolvimento considerável nos últimos anos, devido principalmente ao fato de combinar o conhecimento tradicional com as novas abordagens e as modernas tecnologias. Esse desenvolvimento tem como objetivo atender à crescente demanda por novos materiais multifuncionais, com variadas aplicações em Física, Química, Biologia, Agricultura e Medicina. Particularmente, merece destaque o número de trabalhos que tratam da utilização de nanopartículas como cápsulas de armazenamento ou carregadores de espécies de interesse biológico e terapêutico. 1-3Diversos sistemas para liberação controlada de drogas têm sido engendrados e descritos, com suas vantagens e desvantagens comparadas, podendo ser classificados em quatro grupos principais: carregadores virais, compostos catiônicos orgânicos, proteínas recombinantes e nanopartículas inorgânicas. Exemplos recentes incluem: pontos quânticos (quantum dots) ou nanocompósitos magnético-fluorescentes; 4,5 géis poliméricos; 6,7 nanotubos de carbono ou sílica funcionalizados; 8 cápsulas multilamelares de polieletrólitos; 9 nanopartículas de ouro 10,11 e hidróxidos duplos lamelares (HDL). 12A Figura 1 mostra alguns exemplos de espécies nanoparticuladas de interesse na área médica. Particularmente, a busca por terapias antitumorais novas e racionais, aliadas às técnicas de diagnóstico mais seguras, envolve o planejamento e a obtenção de drogas ou fármacos alvo-específicos, isto é, que tenham alta especificidade para determinada biomolécula ou componente celular, podendo então serem transportados e liberados apenas em sítios escolhidos ou apropriados, aumentando sua eficácia terapêutica e diminuindo seus efeitos colaterais. Uma estratégia criativa é utilizar nanopartículas multifuncionais, capazes de carregar o fármaco e que, adicionalmente, contenham um composto (proteína, anticorpo ou ligante) reconhecido apenas por proteínas ou receptores associados a células tumorais (biomarcadores). Dessa ...

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Nanohybrids for controlled antibiotic release in topical applications

Cited by 76 publications

References 23 publications

Encapsulation of Diclofenac Molecules into Poly(ε‐Caprolactone) Electrospun Fibers for Delivery Protection

Encapsulation of Diclofenac Molecules into Poly(ε‐Caprolactone) Electrospun Fibers for Delivery Protection

Versatile Nanocomposite Formulation System of Non-Steroidal Anti-Inflammatory Drugs of the Arylalkanoic Acids

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

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