Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Quazi, Mohzibudin Z.; Park, Nokyoung

doi:10.3390/ijms23041943

Cited by 38 publications

(41 citation statements)

References 131 publications

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“…Lowering the reaction temperature increased the elastic modulus and tensile strength while decreasing the elongation at break. The biocompatibility, antibacterial properties, ability to effectively cure wounds, and toxicity of the developed HG were all tested [76].…”

Section: Pva-based Nano-hydrogelmentioning

confidence: 99%

Production of Polymer Hydrogel Composites and Their Applications

Sayed

2023

J Polym Environ

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Hydrogels are three-dimensional cross-linked stable network insoluble in water, which gives them a remarkable capacity to absorb both water and biological fluids. Hydrogel has been synthesized from natural or synthetic polymers and/or monomers, which have made tremendous advancements in many different applications. Composite hydrogel is a type of hydrogel prepared by grafting hydrophilic groups, such as hydroxyl (–OH), carboxylic acid (–COOH), imide (–CONH), sulfonic acid (–SO3H), amine (–NH2), and amide (–CONH2), into the polymer chain’s backbone and adding some additives such as kaolin, zeolite, or even different types of nanoparticles. Whereas the polymeric composite hydrogels exhibit stimuli for different properties such as pH, temperature, or light, which may affect swelling, mechanical properties, and self-healing, which in turn play vital roles in different areas. Hence, numerous efforts have been made to synthesize polymer-based composited hydrogels via physical or chemical crosslinking techniques to enhance their physiochemical, biological, and many other properties. Many researchers are currently paying attention to hydrogels and their applications, including wastewater treatment and purification, medical and biomedical applications, agricultural applications, and many other industrial applications. The aim of this review is to summarize the classification of composite hydrogels based on their chemical and physical crosslinking techniques, in addition to the different polymers and additives used to prepare composite hydrogels. Furthermore, the impact of hydrogel on health and the environment has been discussed. Other significant issues were also presented, including the challenges that face hydrogel production and application, which have been discussed.

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Section: Pva-based Nano-hydrogelmentioning

confidence: 99%

Production of Polymer Hydrogel Composites and Their Applications

Sayed

2023

J Polym Environ

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“…Nanohydrogels are three-dimensional (3D)-polymeric networks of nanoscale dimensions, with a crosslinked structure that gives them potential flexibility and versatile behaviour [ 62 , 63 ]. They have the dual advantage of hydrogels, allowing for the high encapsulation efficiency of hydrophilic compounds, and of nanostructures, allowing for high cellular internalisation [ 64 ].…”

Section: Ha-based Nanosystemsmentioning

confidence: 99%

Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity

Salathia

Gigliobianco

Casadidio

et al. 2023

IJMS

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The nervous and immune systems go hand in hand in causing inflammation and pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others are caused by it. Macrophages play an important role in modulating inflammation to trigger neuropathic pain. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving inflammation by varying the molecular weight of HA is a debated concept. HA-based drug delivery nanosystems such as nanohydrogels and nanoemulsions, targeting macrophages can be used to relieve pain and inflammation by loading antinociceptive drugs and enhancing the effect of anti-inflammatory drugs. This review will discuss the ongoing research on HA-based drug delivery nanosystems regarding their antinociceptive and anti-inflammatory effects.

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“…The development of bionanomaterials to exert selective cancer therapeutics with negligible cytotoxicity to normal cells is the major concern in which researchers have shown a keen interest. 1 Peptide drug-based therapies have several advantages extensively due to easy accessibility and convenient purification. 2 Some of them were clinically approved and available in the market.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The targeted delivery of therapeutics has attracted wide interest in recent times. The development of bionanomaterials to exert selective cancer therapeutics with negligible cytotoxicity to normal cells is the major concern in which researchers have shown a keen interest . Peptide drug-based therapies have several advantages extensively due to easy accessibility and convenient purification .…”

Section: Introductionmentioning

confidence: 99%

DNA Hydrogel-Based Nanocomplexes with Cancer-Targeted Delivery and Light-Triggered Peptide Drug Release for Cancer-Specific Therapeutics

Quazi¹,

Park²

2023

Biomacromolecules

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Cancer therapies based on chemotherapeutic drug delive ries have been the most facilitated studies. Recently, peptide drugs have emerged as anticancer drugs due to their less immunogenicity and lower production costs compared with other synthetics. However, still, the side effects of these chemotherapeutics on healthy tissues have been a great concern to deal with, and these side effects are usually caused by off-targeted delivery and unwanted leakage. In addition, peptides are easily degraded by enzyme attacks during delivery. To address these concerns, here, we developed a robust, cancer-specific peptide drug delivery system with negligible cytotoxicity in in vitro. A peptide drug delivery vehicle (Dgel-PD-AuNP-YNGRT) was constructed by stepwise functionalization on a nanoscale DNA hydrogel (Dgel). A cell-penetrating anticancer peptide drug, Buforin IIb, was loaded within the Dgel network via electrostatic attraction followed by AuNP assembly. The AuNPs were employed as photothermal reagents for light-triggered peptide drug release. An additional peptide, including a cancer-targeting YNGRT sequence, was also bound on the Dgel for cancer-cell-targeted delivery. According to the results obtained from the studies employing cancer cells as well as normal cells, Dgel-PD-AuNP-YNGRT nanocomplexes could be delivered specifically to cancer cells, activated by light illumination, and release anticancer peptide drugs to kill cancer cells with no cytotoxicity and negligible hazardous effect on normal cell lines. The obtained cell viability assay suggests that at a high intensity (15 W/cm2), photothermally triggered released peptide drug has shown up to 44% higher kill than only peptide drug treatments in cancer cells. Similarly, the Bradford assay demonstrated that up to 90% of peptide drugs were released with our engineered Dgel-PD-AuNP-YNGRT nanocomplex. The Dgel-PD-AuNP-YNGRT nanocomplex may serve as an ideal anticancer peptide drug delivery platform for safe, cancer-specific targeting and efficient peptide drug delivery in cancer therapy.

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Nanohydrogels: Advanced Polymeric Nanomaterials in the Era of Nanotechnology for Robust Functionalization and Cumulative Applications

Cited by 38 publications

References 131 publications

Production of Polymer Hydrogel Composites and Their Applications

Production of Polymer Hydrogel Composites and Their Applications

Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity

DNA Hydrogel-Based Nanocomplexes with Cancer-Targeted Delivery and Light-Triggered Peptide Drug Release for Cancer-Specific Therapeutics

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