Nanohydroxyapatite/cellulose nanocrystals/silk fibroin ternary scaffolds for rat calvarial defect regeneration

Chen, Xiaoming; Runmei, Zhou; Chen, Bin; Chen, Jianting

doi:10.1039/c6ra02038k

Cited by 27 publications

(9 citation statements)

References 33 publications

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“…A similar system based on nanocellulose, hydroxyapatite, and silk fibroin has been proposed for the regeneration of a rat brain/skull defect ( Figure 9 ) [ 118 ]. When investigating the effect of the nanocomposite on MC3T3-F1 cells’ viability, it was found that the cell viability at 5 and 7 days was much higher than that of samples without the composite material.…”

Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

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Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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Nanotechnology plays an important role in biological research, especially in the development of delivery systems with lower toxicity and greater efficiency. These include not only metallic nanoparticles, but also biopolymeric nanoparticles. Biopolymeric nanoparticles (BPNs) are mainly developed for their provision of several advantages, such as biocompatibility, biodegradability, and minimal toxicity, in addition to the general advantages of nanoparticles. Therefore, given that biopolymers are biodegradable, natural, and environmentally friendly, they have attracted great attention due to their multiple applications in biomedicine, such as drug delivery, antibacterial activity, etc. This review on biopolymeric nanoparticles highlights their various synthesis methods, such as the ionic gelation method, nanoprecipitation method, and microemulsion method. In addition, the review also covers the applications of biodegradable polymeric nanoparticles in different areas—especially in the pharmaceutical, biomedical, and agricultural domains. In conclusion, the present review highlights recent advances in the synthesis and applications of biopolymeric nanoparticles and presents both fundamental and applied aspects that can be used for further development in the field of biopolymeric nanoparticles.

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Section: Main Applications Of Biodegradable Polymeric Nanoparticlesmentioning

confidence: 99%

“… Illustration of the different repair results in rat calvarial defects assessed by micro-CT. Reproduced with permission from [ 118 ], 2011, Royal Society of Chemistry. …”

Section: Figurementioning

confidence: 99%

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

et al. 2022

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“…Bone defects can result in severe complications such as pain, obvious limitation in daily activities, and sometimes even lead to psychological problems. − Tissue engineering scaffold has been rapidly developed as a viable approach to regenerate bone . Implantation of bioactive scaffolds alone or in combination with growth factors into a defect site can recruit host cells for the purpose of inducing osteogenic differentiation of the cells for bone regeneration …”

Section: Introductionmentioning

confidence: 99%

“…Ideal bone biomaterials should have good mechanical properties, excellent biocompatibility, and should be degraded at moderate rates to be consistent with bone regeneration, which are crucial for the repair of bone defects. Furthermore, good osteoconductivity, even osteoinductivity, and high porosity with interconnecting structures were also highly demanded . Many inorganic materials have been applied to prepare bone tissue engineering scaffolds such as nanohydroxyapatite (nHAp), β-tricalcium phosphate (β-TCP), and bioactive glass.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of BMP-2 from a Heparin-Conjugated Strontium-Substituted Nanohydroxyapatite/Silk Fibroin Scaffold for Bone Regeneration

Yan

Feng

Zhu

et al. 2018

ACS Biomater. Sci. Eng.

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The objective of this study was to develop heparin-conjugated strontium-substituted hydroxyapatite/silk fibroin (Sr-nHAp/SF-Hep) scaffold loaded bone morphogenetic proteins-2 (BMP-2) with sustained release to improve bone regeneration. The average pore diameters and porosity of Sr-nHAp/SF scaffolds were respectively approximately 150 μm and 90%. The mechanical properties and thermostability of the Sr-nHAp/SF scaffolds were significantly stronger than those of the SF scaffold. The weight of composite scaffolds is higher than that of the SF scaffold in simulated body fluids. The Sr-nHAp/SF scaffold exhibited excellent biological function of bone marrow mesenchymal stem cell (BMSC) proliferation and adhesion. The expression of related osteogenic genes, including osteocalcin, osteopontion, and alkaline phosphatase activity was elevated by Sr-nHAp/SF-Hep-BMP-2 scaffold, which promoted the differentiation of BMSCs into osteoblasts. In vivo results showed that Sr-nHAp/SF-Hep-BMP-2 scaffolds enhanced bone mineral density and improved new bone regeneration, which was accomplished through microcomputed tomography (micro-CT) and histological and histochemical staining analysis. These results demonstrated Sr-nHAp/SF-Hep-BMP-2 scaffolds with favorable biocompatibility and good mechanical properties have great potential to repair bone defects.

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“…[13][14][15][16] Among natural biopolymer materials, natural proteins isolated from animal tissues or animal plasmas are widely studied for constructing tissue engineering scaffolds, due to their excellent biocompatibility, biodegradability, absorbability, and available approaches of isolation from the varied sources. [17][18][19][20] Proteins are generally fabricated into porous scaffolds by first cross-linking reaction and then freeze-drying technique. The cross-linking reaction is employed to improve the mechanical stability of protein scaffolds.…”

Section: Introductionmentioning

confidence: 99%

One‐Pot Fabrication of Poly(ε‐Caprolactone)‐Incorporated Bovine Serum Albumin/Calcium Alginate/Hydroxyapatite Nanocomposite Scaffolds by High Internal Phase Emulsion Templates

Han

Chen

et al. 2016

Macro Materials & Eng

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In this work, the authors report an effective one‐pot method to prepare poly(ε‐caprolactone) (PCL)‐incorporated bovine serum albumin (BSA)/calcium alginate/hydroxyapatite (HAp) nanocomposite (NC) scaffolds by templating oil‐in‐water high internal phase emulsion (HIPE), which includes alginate, BSA, and HAp in water phase and PCL in oil phase. The water phase of HIPEs is solidified to form hydrogels containing emulsion droplets via gelation of alginate induced by Ca2+ ions released from HAp. And the prepared hydrogels are freeze‐dried to obtain PCL‐incorporated porous scaffolds. The obtained scaffolds possess interconnected pore structures. Increasing PCL concentration clearly enhances the compressive property and BSA stability, decreases the swelling ratio of scaffolds, which assists in improving the scaffold stability. The anti‐inflammatory drug ibuprofen can be highly efficiently loaded into scaffolds and released in a sustained rate. Furthermore, mouse bone mesenchymal stem cells can successfully proliferate on the scaffolds, proving the biocompatibility of scaffolds. All results show that the PCL‐incorporated NC scaffolds possess promising potentials in tissue engineering application.

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Nanohydroxyapatite/cellulose nanocrystals/silk fibroin ternary scaffolds for rat calvarial defect regeneration

Abstract: The purpose of this study was to design and characterise a novel biomimetic scaffold for the repair of critical size calvarial defects.

Cited by 27 publications

References 33 publications

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

Biopolymeric Nanoparticles–Multifunctional Materials of the Future

Controlled Release of BMP-2 from a Heparin-Conjugated Strontium-Substituted Nanohydroxyapatite/Silk Fibroin Scaffold for Bone Regeneration

One‐Pot Fabrication of Poly(ε‐Caprolactone)‐Incorporated Bovine Serum Albumin/Calcium Alginate/Hydroxyapatite Nanocomposite Scaffolds by High Internal Phase Emulsion Templates

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