Nanoliposomal minocycline for ocular drug delivery

Kaiser, James; Imai, Hisanori; Haakenson, Jeremy K.; Brucklacher, Robert M.; Fox, Todd E.; Shanmugavelandy, Sriram S.; Unrath, Kellee A.; Pedersen, Michelle M.; Dai, Pingqi; Freeman, Willard M.; Bronson, Sarah K.; Gardner, Thomas W.; Kester, Mark

doi:10.1016/j.nano.2012.03.004

Cited by 52 publications

(20 citation statements)

References 36 publications

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“…They obtained SUV (Small Unilamellar Vesicles) with an average particle size of 80 nm ± 20 nm. The authors concluded on a higher release of drug than free minocycline in the retina with loaded liposomes [ 174 ].…”

Section: Recent Advances For Ocular Antibiotics Administrationmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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The last fifty years, ophthalmic drug delivery research has made much progress, challenging scientists about the advantages and limitations of this drug delivery approach. Topical eye drops are the most commonly used formulation in ocular drug delivery. Despite the good tolerance for patients, this topical administration is only focus on the anterior ocular diseases and had a high precorneal loss of drugs due to the tears production and ocular barriers. Antibiotics are popularly used in solution or in ointment for the ophthalmic route. However, their local bioavailability needs to be improved in order to decrease the frequency of administrations and the side effects and to increase their therapeutic efficiency. For this purpose, sustained release forms for ophthalmic delivery of antibiotics were developed. This review briefly describes the ocular administration with the ocular barriers and the currently topical forms. It focuses on experimental results to bypass the limitations of ocular antibiotic delivery with new ocular technology as colloidal and in situ gelling systems or with the improvement of existing forms as implants and contact lenses. Nanotechnology is presently a promising drug delivery way to provide protection of antibiotics and improve pathway through ocular barriers and deliver drugs to specific target sites.

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Section: Recent Advances For Ocular Antibiotics Administrationmentioning

confidence: 99%

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

et al. 2018

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“…Studies have demonstrated that by applying this method, a controlled drug release as well as membrane permeability can be achieved. Therefore, the half-life of the drug inside the vitreous body can be prolonged, and the toxicity of the drug can be reduced (Llopis et al, 1992;Cheng et al, 2000;Kaiser et al, 2013). We feel obliged to promote the bioavailability of drugs in the treatment on posterior segment of the eyes.…”

Section: Introductionmentioning

confidence: 99%

Preparation and ocular pharmacokinetics of hyaluronan acid-modified mucoadhesive liposomes

Lin

Wang

et al. 2014

Drug Delivery

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The aim of this research was to formulate a liposomal preparation of DOX to be applied topically, and to investigate the in vitro and in vivo performance of the prepared liposomes. DOX liposomes were prepared by the solvent evaporation method, and then modified with bioadhesive material HA. Through MTT assay, we found that the safe concentration of liposomes delivered would hit 1 mg/mL. Cellular uptake studies showed that DOX liposomes coated with HA are much more targetable to cell nucleus. Their ocular pharmacokinetics in rabbits were investigated through the comparison with those obtained after dosing with nonmodified liposomes and DOX solution. The in vitro transcorneal permeability of DOX in both kinds of liposomes was found to be slower than that of the solution because of sustained release. After in vivo instillation in rabbits, HA-modified liposomes had the longest retention time, following with naked liposomes. Significantly, the area under the curve of the aqueous humor concentration-time profiles of DOX liposomes was found to be 1.7-fold higher than that of DOX solution. The confocal experiment confirmed that HA-modified liposomes were able to maintain a higher DOX concentration and residence time than that of non-modified liposomes and free DOX. These results suggest that our liposomal preparation was of great help to improve the bioavailability of DOX.

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“…Western Blots-Whole cell lysates were isolated using Nonidet P-40 lysis buffer as previously described (11). Protein quantification was completed using the DC protein assay (Bio-Rad).…”

Section: Methodsmentioning

confidence: 99%

Lysosomal Degradation of CD44 Mediates Ceramide Nanoliposome-induced Anoikis and Diminished Extravasation in Metastatic Carcinoma Cells

Haakenson

Khokhlatchev

Choi

et al. 2015

Journal of Biological Chemistry

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Background: Even though ceramide selectively induces apoptosis in multiple cancer models, the mechanisms by which ceramide limits cancer metastasis are unknown. Results: The ceramide nanoliposome (CNL) inhibits cancer cell metastasis by inducing anoikis and inhibiting extravasation via lysosomal degradation of CD44. Conclusion: Ceramide reduces the metastatic potential of multiple cancer cell models. Significance: CNL may have therapeutic utility in preventing and treating metastatic cancers.

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Nanoliposomal minocycline for ocular drug delivery

Cited by 52 publications

References 36 publications

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Ophthalmic Drug Delivery Systems for Antibiotherapy—A Review

Preparation and ocular pharmacokinetics of hyaluronan acid-modified mucoadhesive liposomes

Lysosomal Degradation of CD44 Mediates Ceramide Nanoliposome-induced Anoikis and Diminished Extravasation in Metastatic Carcinoma Cells

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