Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond

Safarkhani, Moein; Aldhaher, Abdullah; Heidari, Golnaz; Zare, Ehsan Nazarzadeh; Warkiani, Majid Ebrahimi; Akhavan, Omid; Huh, YunSuk; Rabiee, Navid

doi:10.1016/j.nanoms.2023.11.009

Cited by 19 publications

(5 citation statements)

References 148 publications

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“…Moreover, using nanoparticles to enhance sensitivity to light is an innovative approach to non-invasive glucose control [ 121 ]. Theoretical nanoparticles, intended for intravenous delivery and activation using precise light wavelengths, have the potential to stimulate insulin production.…”

Section: Another Possible Mechanismmentioning

confidence: 99%

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management

Nurkolis,

Kurniawan,

Wiyarta

et al. 2024

Molecules

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Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation. Despite numerous efforts, effectively addressing diabetes remains a challenge. This article explores the potential of photoactivatable drugs in diabetes treatment, with a focus on light-activated insulin. We discuss its advantages and significant implications. This article is expected to enrich the existing literature substantially, offering a comprehensive analysis of potential strategies for improving diabetes management. With its minimal physical intrusion, light-activated insulin promises to improve patient comfort and treatment adherence. It offers precise regulation and localized impact, potentially mitigating the risks associated with conventional diabetes treatments. Additionally, light-activated insulin is capable of explicitly targeting RNA and epigenetic factors. This innovative approach may pave the way for more personalized and effective diabetes treatments, addressing not only the symptoms but also the underlying biological causes of the disease. The advancement of light-activated insulin could revolutionize diabetes management. This study represents a pioneering introduction to this novel modality for diabetes management.

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Section: Another Possible Mechanismmentioning

confidence: 99%

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management

Nurkolis,

Kurniawan,

Wiyarta

et al. 2024

Molecules

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“…622 For efficient management of diabetes, nanosensors can be injected into the skin or can be used as a wearable device for continuous glucose monitoring. 623,624 . 622 For efficient management of diabetes, nanosensors can be injected into the skin or can be used as a wearable device for continuous glucose monitoring.…”

Section: Nanosensors In Cancermentioning

confidence: 99%

“…622 For efficient management of diabetes, nanosensors can be injected into the skin or can be used as a wearable device for continuous glucose monitoring. 623,624 Nanosensors are also being developed that can perform metabolite detection from bodily fluids such as sweat, blood, urine, plasma, etc. 625,626 Nanofabricated sensors can also be implanted in eyes to monitor intraocular pressure which can be important for managing conditions such as glaucoma.…”

Section: Nanosensors In Cancermentioning

confidence: 99%

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Hughes,

Ganesan,

Tenchov

et al. 2024

Preprint

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Since their inception in the early 1960s, the use of nanoscale materials has progressed in leaps and bounds, and their role in diverse fields ranging from human health to energy is undeniable. In this report, we utilize the CAS Content Collection, a vast repository of scientific information extracted from journal and patent publications, to identify emerging topics in this field. This involves understanding trends, such as the growth of certain topics over time, as well as establishing relationships between emerging topics. We achieved this by using a host of strategies including a quantitative natural language processing (NLP) approach to identify 279 emerging topics and sub-topics across three major categories – materials, applications, and properties – by surveying roughly 3 million publications in the nanoscience landscape. This wealth of information has been condensed into several conceptual mind maps and other graphs that provide metrics related to the growth of identified emerging concepts, group them into hierarchical classes, and explore the connections between them. We delved deeper into four major emerging applications of nanoscale materials – drug delivery, sensors, energy, and catalysis – to provide a more comprehensive and detailed picture of the use of nanotechnology in these fields. In addition, we leveraged the CAS registry, consisting of over 250 million substances, to determine and discover substances across varied classes (such as polymers, elements, organic/inorganic molecules) and how they are utilized in the 4 major applications. Our extensive analysis taking advantage of an NLP-based approach along with robust CAS indexing provides valuable insights in the field that we hope can help to inform and drive future research efforts.

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“…The human brain achieves complex computations and intelligent behaviors through the regulation of ion transport in the ion channels of neuronal cells, utilizing ionic information carriers, − which is a major difference between the brain neural network and electronic circuits in terms of the underlying mechanisms of information processing. − This understanding provides new insights for the development of bioinspired nanofluidic iontronics that employ ion-based nanochannels to emulate functions of biological neural networks, such as action potential spikes and synaptic memory, − based on ion signals.…”

Section: Introductionmentioning

confidence: 99%

Single-Pore Nanofluidic Logic Memristor with Reconfigurable Synaptic Functions and Designable Combinations

Ling,

Yu,

Guo

et al. 2024

J. Am. Chem. Soc.

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The biological neural network is a highly efficient inmemory computing system that integrates memory and logical computing functions within synapses. Moreover, reconfiguration by environmental chemical signals endows biological neural networks with dynamic multifunctions and enhanced efficiency. Nanofluidic memristors have emerged as promising candidates for mimicking synaptic functions, owing to their similarity to synapses in the underlying mechanisms of ion signaling in ion channels. However, realizing chemical signal-modulated logic functions in nanofluidic memristors, which is the basis for brain-like computing applications, remains unachieved. Here, we report a single-pore nanofluidic logic memristor with reconfigurable logic functions. Based on the different degrees of protonation and deprotonation of functional groups on the inner surface of the single pore, the modulation of the memristors and the reconfiguration of logic functions are realized. More noteworthy, this single-pore nanofluidic memristor can not only avoid the average effects in multipore but also act as a fundamental component in constructing complex neural networks through series and parallel circuits, which lays the groundwork for future artificial nanofluidic neural networks. The implementation of dynamic synaptic functions, modulation of logic gates by chemical signals, and diverse combinations in singlepore nanofluidic memristors opens up new possibilities for their applications in brain-inspired computing.

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Nanomaterial-assisted wearable glucose biosensors for noninvasive real-time monitoring: Pioneering point-of-care and beyond

Cited by 19 publications

References 148 publications

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management

Nanoscale materials at work: Mapping emerging applications in energy, medicine, and beyond

Single-Pore Nanofluidic Logic Memristor with Reconfigurable Synaptic Functions and Designable Combinations

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