2015
DOI: 10.1039/c5ay00990a
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Nanomaterial based mass spectrometry of oligodeoxynucleotide–drug complexes

Abstract: Surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) using HgTe nanostructures as the matrix has been employed for the detection of four 15-base oligodeoxynucleotides (ODNs) that are genes found in acute myeloid leukemia (AML) patients and their complexes with mitoxantrone (MTX), which is a common drug for the treatment of AML patients. The major peaks for the four tested ODNs are at m/z values of 4571, 4586, 4610, and 4635, while they are at m/z values of 5017, 5031, 5055, and 5079 for th… Show more

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“…However, exfoliating III‐nitride films from such single‐crystalline substrates proves difficult because of the strong sp 3 ‐type covalent bonds between the substrates and epilayers . To overcome this problem, thermal release through laser radiation, stamp‐based printing, chemical etching, and mechanical exfoliation from single‐crystalline substrates have been investigated. However, there still remain some bottlenecks for future applications, such as damage, limited size, and tedious steps of the flexible production process .…”
Section: Introductionmentioning
confidence: 99%
“…However, exfoliating III‐nitride films from such single‐crystalline substrates proves difficult because of the strong sp 3 ‐type covalent bonds between the substrates and epilayers . To overcome this problem, thermal release through laser radiation, stamp‐based printing, chemical etching, and mechanical exfoliation from single‐crystalline substrates have been investigated. However, there still remain some bottlenecks for future applications, such as damage, limited size, and tedious steps of the flexible production process .…”
Section: Introductionmentioning
confidence: 99%