Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer’s Disease

Phan, Le Minh Tu; Hoang, Thi Xoan; Vo, Thuy Anh Thu; Pham, Hoang Lan; Le, Hien T. Ngoc; Chinnadayyala, Somasekhar R.; Kim, Jae Young; Lee, Sang-Myung; Cho, Won Woo; Kim, Young Hyo; Choi, Seong Hye; Cho, Sungbo

doi:10.1080/14737159.2021.1887732

Cited by 27 publications

(14 citation statements)

References 147 publications

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“…It has to be mentioned that although our findings did not support that glaucoma is an independent risk factor for subsequent development of AD, in view of the lack of effective strategies for early screening of AD before the occurrence of memory dysfunction ( 41 ), ophthalmologic examinations remain of potential as early screening tools for AD. With the development of novel techniques such as retinal optical coherence tomography ( 42 , 43 ) and nanomaterial biosensors ( 44 ), it could be expected that eye clinics and ophthalmology facilities may play important roles in the early diagnosis of AD and subsequent reducing the burdens arising from severe dementia ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies

Zhao

et al. 2021

Front. Med.

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Background: Previous studies evaluating the relationships of glaucoma with Alzheimer's disease (AD) and dementia showed inconsistent results. We performed a meta-analysis of cohort studies to evaluate the association between glaucoma with incidence of AD, all-cause dementia, and non-AD dementia.Methods: Cohort studies which evaluated the association between glaucoma with incidence of AD, all-cause dementia, and non-AD dementia in adult population with multivariate analyses were identified by systematic search of PubMed, Embase, and Cochrane's Library databases. A random-effects model incorporating the potential intra-study heterogeneity was used for the meta-analysis.Results: Eleven cohort studies including 4,645,925 participants were included. Results showed that compared to those without glaucoma at baseline, adult patients with glaucoma was not independently associated with increased incidence of AD [adjusted risk ratio (RR): 1.03, 95% confidence interval (CI): 0.93–1.05, P = 0.55; I2 = 83%], all-cause dementia (adjusted RR: 1.08, 95% CI: 0.97–1.19, P = 0.15; I2 = 79%), or non-AD dementia (adjusted RR: 1.05 95% CI: 0.91–1.21, P = 0.49; I2 = 82%). Sensitivity analyses by excluding one study at a time did not significantly affect the results of the meta-analyses. Moreover, subgroup analyses showed consistent results in meta-analysis of prospective or retrospective cohort studies, and in meta-analysis of patients with primary open-angle glaucoma or primary angle-closure glaucoma (P-values for subgroup difference all > 0.05).Conclusions: Current evidence from cohort studies did not support that glaucoma is an independent risk factor of AD, all-cause dementia, or non-AD dementia in adult population.

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Section: Discussionmentioning

confidence: 99%

Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies

Zhao

et al. 2021

Front. Med.

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“…EC MOF biosensors represent a sophisticated platform designed to detect and quantify amyloid species (AD and PD). 118 These sensors harness the principles of electrochemistry, measuring changes in electrical properties, such as current or potential, when amyloid species interact with the sensor surface. 119 MOFs, known for their high surface area and tunable properties, are functionalized with specific receptors, such as antibodies or aptamers.…”

Section: Mofs In Biosensingmentioning

confidence: 99%

Amyloid detection in neurodegenerative diseases using MOFs

Maru,

Singh,

Jangir

et al. 2024

J. Mater. Chem. B

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“…Laboratory tests include genetic tests, biomarker detections, and CSF analysis [23]. In addition to aforementioned techniques, molecular imaging, mass spectrometry, and electrochemical techniques were also used for quantitative biomarker detection [24][25][26][27][28][29]. These methods and techniques have several limitations as complicated and sophisticated system design, difficulties in optimization and operation of system setup, the total cost of the systems, and challenges in obtaining high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Application of fiber loop ringdown spectroscopy technique for a new approach to beta-amyloid monitoring for Alzheimer Disease’s early detection

Kaya,

Oz,

Esenturk

2024

Biomed. Phys. Eng. Express

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A novel fiber optic biosensor was purposed for a new approach to monitor amyloid beta protein fragment 1-42 (Aβ42) for Alzheimer’s Disease (AD) early detection. The sensor was fabricated by etching a part of fiber from single mode fiber loop in pure hydrofluoric acid solution and utilized as a Local Optical Refractometer (LOR) to monitor the change Aβ42 concentration in Artificial Cerebrospinal Fluid (ACSF). The Fiber Loop Ringdown Spectroscopy (FLRDS) technique is an ultra-sensitive measurement technique with low-cost, high sensitivity, real-time measurement, continuous measurement and portability features that was utilized with a fiber optic sensor for the first time for the detection of a biological signature in an ACSF environment. Here, the measurement is based on the total optical loss detection when specially fabricated sensor heads were immersed into ACSF solutions with and without different concentrations of Aβ42 biomarkers since the bulk refractive index change was performed. Baseline stability and the reference ring down times of the sensor head were measured in the air as 0.87% and 441.6 μs  3.9 μs, respectively. Afterward, the total optical loss of the system was measured when the sensor head was immersed in deionized water, ACSF solution, and ACSF solutions with Aβ42 in different concentrations. The lowest Aβ42 concentration of 2 ppm was detected by LOR. Results showed that LOR fabricated by single-mode fibers for FLRDS system design are promising candidates to be utilized as fiber optic biosensors after sensor head modification and have a high potential for early detection applications of not only AD but possibly also several fatal diseases such as diabetes and cancer.

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Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer’s Disease

Cited by 27 publications

References 147 publications

Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies

Glaucoma Is Not Associated With Alzheimer's Disease or Dementia: A Meta-Analysis of Cohort Studies

Amyloid detection in neurodegenerative diseases using MOFs

Application of fiber loop ringdown spectroscopy technique for a new approach to beta-amyloid monitoring for Alzheimer Disease’s early detection

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