Nanomaterial-based sensors for the detection of biological threat agents

Rowland, Clare E.; Brown, Carl W.; Delehanty, James B.; Medintz, Igor L.

doi:10.1016/j.mattod.2016.02.018

Cited by 69 publications

(42 citation statements)

References 118 publications

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“…Synthetic methods for nanoparticle production have evolved to the extent that particle size, shape, and composition can be tuned [1][2][3][4] . They have been integrated into many aspects of modern life [5][6][7][8][9][10] such as information technology, medical equipment and energy. Gold nanoparticles (AuNPs) of varying morphologies are especially sought after as they have many applications in catalysis [11][12][13] , biosensing [14][15][16][17][18] and therapeutics 19,20 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Using the Interface of an Emulsion Droplet

Sachdev¹,

Maugi²,

Woolley³

et al. 2017

Langmuir

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A facile and rapid method for synthesizing single crystal gold spherical or platelet (nonspherical) particles is reported. The reaction takes place at the interface of two immiscible liquids where the reducing agent decamethylferrocene (DmFc) was initially added to hexane and gold chloride (AuCl) to an aqueous phase. The reaction is spontaneous at room temperature, leading to the creation of Au nanoparticles (AuNP). A flow focusing microfluidic chip was used to create emulsion droplets, allowing the same reaction to take place within a series of microreactors. The technique allows the number of droplets, their diameter, and even the concentration of reactants in both phases to be controlled. The size and shape of the AuNP are dependent upon the concentration of the reactants and the size of the droplets. By tuning the reaction parameters, the synthesized nanoparticles vary from nanometer to micrometer sized spheres or platelets. The surfactant used to stabilize the emulsion was also shown to influence the particle shape. Finally, the addition of other nanoparticles within the droplet allows for core@shell particles to be readily formed, and we believe this could be a versatile platform for the large scale production of core@shell particles.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Using the Interface of an Emulsion Droplet

Sachdev¹,

Maugi²,

Woolley³

et al. 2017

Langmuir

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“…Biosensors can be designed to respond to targeted markers and can provide output for detection as electrical, chemical, optical signal or other modalities. Thus, biosensors must consist of a sensor component, a signal transducer, and a signal processor [143][144][145]. In addition, biosensors must have adjustable properties and a high ratio of surface area to volume [126].…”

Section: Dna Biosensorsmentioning

confidence: 99%

DNA Microsystems for Biodiagnosis

2020

Self Cite

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Researchers are continuously making progress towards diagnosis and treatment of numerous diseases. However, there are still major issues that are presenting many challenges for current medical diagnosis. On the other hand, DNA nanotechnology has evolved significantly over the last three decades and is highly interdisciplinary. With many potential technologies derived from the field, it is natural to begin exploring and incorporating its knowledge to develop DNA microsystems for biodiagnosis in order to help address current obstacles, such as disease detection and drug resistance. Here, current challenges in disease detection are presented along with standard methods for diagnosis. Then, a brief overview of DNA nanotechnology is introduced along with its main attractive features for constructing biodiagnostic microsystems. Lastly, suggested DNA-based microsystems are discussed through proof-of-concept demonstrations with improvement strategies for standard diagnostic approaches.

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“…Other platforms use silica NPs as immobilization platforms for the detection of Escherichia coli [ 95 ]. Immobilization of the biosensing element on nanomaterials was shown to enhance the molecular recognition and increase the selectivity [ 68 , 96 , 97 , 98 , 99 , 100 ]. Three-dimensional modeling was used for nano-manipulations and predicting the selectivity towards different analyes [ 99 , 101 , 102 ].…”

Section: Nanotechnology-enabled Sensors and Sensing Systems For Dementioning

confidence: 99%

Multifunctional Nanotechnology-Enabled Sensors for Rapid Capture and Detection of Pathogens

Mustafa

Hassan

2017

Sensors

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Nanomaterial-based sensing approaches that incorporate different types of nanoparticles (NPs) and nanostructures in conjunction with natural or synthetic receptors as molecular recognition elements provide opportunities for the design of sensitive and selective assays for rapid detection of contaminants. This review summarizes recent advancements over the past ten years in the development of nanotechnology-enabled sensors and systems for capture and detection of pathogens. The most common types of nanostructures and NPs, their modification with receptor molecules and integration to produce viable sensing systems with biorecognition, amplification and signal readout are discussed. Examples of all-in-one systems that combine multifunctional properties for capture, separation, inactivation and detection are also provided. Current trends in the development of low-cost instrumentation for rapid assessment of food contamination are discussed as well as challenges for practical implementation and directions for future research.

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Nanomaterial-based sensors for the detection of biological threat agents

Cited by 69 publications

References 118 publications

Synthesis of Gold Nanoparticles Using the Interface of an Emulsion Droplet

Synthesis of Gold Nanoparticles Using the Interface of an Emulsion Droplet

DNA Microsystems for Biodiagnosis

Multifunctional Nanotechnology-Enabled Sensors for Rapid Capture and Detection of Pathogens

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