Nanomaterials and Microorganisms: From Green Synthesis to Antibacterial Applications in Medicine and Agriculture

Mortimer, Monika; Kahru, Anne

doi:10.3390/nano12234265

Cited by 2 publications

(3 citation statements)

References 9 publications

(9 reference statements)

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“…[6] Transition-metal oxides are widely employed in pharmaceuticals, construction, electronics, and cosmetics because of their appealing physical and physicochemical properties. [7][8][9] Their inevitable Scheme 1. Ion release and in vitro and in vivo toxicity of metal oxide nanomaterials mitigated by the bLg functional amyloid.…”

Section: Introductionmentioning

confidence: 99%

“…Transition‐metal oxides are widely employed in pharmaceuticals, construction, electronics, and cosmetics because of their appealing physical and physicochemical properties. [ 7 , 8 , 9 ] Their inevitable environmental discharge poses a realistic risk to animals and humans. CuO and ZnO nanoparticles, two of the most representative nanomaterials, have been extensively studied over the past 15 years.…”

Section: Introductionmentioning

confidence: 99%

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Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid

Wang,

Liang,

Andrikopoulos

et al. 2024

Advanced Science

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Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of nanomaterials in cellular and organismal models, the active remediation of the adverse biological and environmental effects of nanomaterials remains largely unexplored. Inspired by recent developments in functional amyloids for biomedical and environmental engineering, this work shows their new utility as metallothionein mimics in the strategically important area of NanoEHS. Specifically, metal ions released from CuO and ZnO nanoparticles are sequestered through cysteine coordination and electrostatic interactions with beta‐lactoglobulin (bLg) amyloid, as revealed by inductively coupled plasma mass spectrometry and molecular dynamics simulations. The toxicity of the metal oxide nanoparticles is subsequently mitigated by functional amyloids, as validated by cell viability and apoptosis assays in vitro and murine survival and biomarker assays in vivo. As bLg amyloid fibrils can be readily produced from whey in large quantities at a low cost, the study offers a crucial strategy for remediating the biological and environmental footprints of transition metal oxide nanomaterials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid

Wang,

Liang,

Andrikopoulos

et al. 2024

Advanced Science

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“…The growing use of metal nanomaterials (including Ag-, Cu-and Zn-based nanoparticles (NPs)) in medical applications but also in various green technologies is expected to result in an elevated environmental burden of toxic metals and NPs [1]. Since soluble metalbased NPs cause toxicity via released toxic metal ions [2,3], the safe use of NPs requires strategies for mitigating their toxicity via the removal of these metal ions.…”

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confidence: 99%