Nanomaterials disrupting cell-cell junctions towards various diseases

Xu, Shanbin; Pang, Xinlong; Zhang, Xinyu; Lv, Qian; Zhang, Meng; Wang, Jinping; Ni, Nengyi; Sun, Xiao

doi:10.1007/s12274-023-5455-y

Cited by 7 publications

(3 citation statements)

References 175 publications

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“…The ability of nano-products to cross blood–brain barrier, cell membranes, placenta, and more, increases the probability of non-specific interaction, that may ultimately cause their unwanted accumulation at tumor site with potential issues like cellular toxicities. 11 One of the most common challenges associated in determination of safety and risk of nanoparticles relates to inherent intrinsic properties of nanoparticles. Despite progress in predicting nanotoxicology, the linkage of inherent physical and chemical features (shape, size, surface charge, pH of membrane, etc) impact on their uptake in the body, and remains as a fundamental problem for determining nanomaterial biotransformation.…”

Section: Conceptual Essaymentioning

confidence: 99%

Blind Spots in Development of Nanomedicines

Salvi,

Kantak,

Kharangate

et al. 2024

Technol Cancer Res Treat

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The field of nanomedicine demonstrates immense advantages and noteworthy expansion compared to conventional drug delivery systems like tablet, capsules, etc. Despite the innumerable advantages, it holds certain shortcomings in the form of blind spots that need to be assessed before the successful clinical translation. This perspective highlights the foremost blind spots in nanomedicine and emphasizes the challenges faced before the entry into the market, including the need for provision of safety and efficacy data by the regulatory agencies like FDA. The significant revolution of nanomedicine in the human life, particularly in patient well-being, necessitates to identify the blind spots and overcome them for effective management and treatment of ailments.

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Section: Conceptual Essaymentioning

confidence: 99%

Blind Spots in Development of Nanomedicines

Salvi,

Kantak,

Kharangate

et al. 2024

Technol Cancer Res Treat

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“…However, a series of pathological processes, such as inflammation, tumor, infection, trauma, etc. will lead to the weakening of endothelial barrier function and the increase of vascular permeability, resulting in a series of harmful effects . Due to the special TME and growth characteristics of the tumor site, the shape of blood vessels formed in the tumor site is often irregular, and the gaps between vascular endothelium are large.…”

Section: Various Mechanisms Involved In Nanomaterials Promoting Tumor...mentioning

confidence: 99%

“…will lead to the weakening of endothelial barrier function and the increase of vascular permeability, resulting in a series of harmful effects. 94 Due to the special TME and growth characteristics of the tumor site, the shape of blood vessels formed in the tumor site is often irregular, and the gaps between vascular endothelium are large. The tumor itself can also activate a series of complex processes to destroy the endothelial barrier and induce vascular endothelial leakage.…”

Section: Interacting With Vasculature By Nanomaterialsmentioning

confidence: 99%

Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis

Wang,

Pang,

Dong

et al. 2023

Environ. Health

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Tumor metastasis is one of the most significant biological characteristics of malignant tumors. Advances in nanotechnology provide a new direction for tackling malignant tumors. Unlike previous studies that focused on the use of nanomaterials to eliminate tumors and avoid metastasis, this work focuses on summarizing the mechanisms by which some nanomaterials promote tumor metastasis in some cases. In this Review, we summarized recent research about various nanomaterials promoting tumor metastasis. The mechanisms of nanomaterials in this process have been highlighted, including the induction of epithelial–mesenchymal transition in tumor cells by nanomaterials, the interaction of nanomaterials with the vasculature, and the induction of inflammation by nanomaterials. Elucidating the mechanism of nanomaterials promoting tumor metastasis is beneficial to guide the development and application of safe and efficient nanomaterials, which can effectively reduce the incidence of tumor metastasis in the future.

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