Nanomaterials for light-mediated therapeutics in deep tissue

Tsang, Chung Yin; Zhang, Yong

doi:10.1039/d3cs00862b

Cited by 17 publications

(3 citation statements)

References 260 publications

(397 reference statements)

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“…It is this fundamental principle that underlies the efficacy of photothermal therapy in eliminating tumor cells. This method has garnered significant attention among researchers due to its non-invasive, precise, and direct localized treatment capabilities [10], facilitated by the ease of focusing and adjusting the applied NIR light. In this therapeutic process, photothermal agents based on nanomaterials, typically ranging in size from 20 to 200 nanometers, play a pivotal role [11].…”

Section: Introductionmentioning

confidence: 99%

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Chen,

Cheng,

Yang

et al. 2024

Nanotechnology

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Pancreatic cancer’s high fatality rates stem from its resistance to systemic drug delivery and aggressive metastasis, limiting the efficacy of conventional treatments. In this study, two-dimensional ultrathin silicene nanosheets (SN) were initially synthesized and near-infrared-responsive two-dimensional silicene-mesoporous silica nanoparticles (SMSNs) were successfully constructed to load the clinically-approved conventional pancreatic cancer chemotherapeutic drug Gemcitabine. Experiments on nanoparticle characterization show that they have excellent photothermal conversion ability and stability. Then silicene-mesoporous silica nanoparticles loaded with Gemcitabine nanoparticles (SMSN@G NPs) were employed in localized photothermal therapy to control pancreatic tumor growth and achieve therapeutic effects. Our research confirmed the functionality of SMSN@G NPs through immunoblotting and apoptotic assays, demonstrating its capacity to enhance the nuclear translocation of the NF-κB p65, further affect the protein levels of apoptosis-related genes, induce the apoptosis of tumor cells, and ultimately inhibit the growth of the tumor. Additionally, the study assessed the inhibitory role of SMSN@G NPs on pancreatic neoplasm growth in vivo, revealing its excellent biocompatibility. SMSN@G NPs have a nice application prospect for anti-pancreatic tumors.

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Section: Introductionmentioning

confidence: 99%

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Chen,

Cheng,

Yang

et al. 2024

Nanotechnology

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“…Chemiluminescence (CL) technology has been extensively used in the domain of analysis due to its high sensitivity, simple instrumentation, and absence of background scattered light for detecting trace level metal ions, inorganic compounds, and small biological molecules. − Although many technologies have been applied in the field of detection, the CL method exhibits higher sensitivity due to the low background emission. Whereas, traditional CL systems are limited in practical applications due to the low inherent signal and poor selectivity.…”

Section: Introductionmentioning

confidence: 99%

Black Phosphorus Quantum Dots with Exposed (113) Planes on Chemiluminescent Luminol–K₃Fe(CN)₆ for Detection of Dopamine

Zhao,

Yang,

Yang

et al. 2024

ACS Appl. Nano Mater.

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Exploring the possible catalytic effect of black phosphorus quantum dots (BPQDs) with specific exposed planes on chemiluminescence (CL) to improve CL intensity and achieve excellent analytical performance is one of the latest research hotspots. Herein, uniform BPQDs with highly exposed (113) facets and an average size of 2.2 nm were fabricated via a facile ultrasonic exfoliation strategy. The enhanced CL intensity in the BPQDs−luminol−K 3 Fe(CN) 6 system is attributed to the catalytic effect of BPQDs. The catalytic mechanism of BPQDs involved in luminol−K 3 Fe(CN) 6 CL is revealed by theoretical calculations, which show an adsorption Gibbs free energy for oxygen of −0.86 eV, accompanied by the separation of electron−hole pairs (e − − h + ). In other words, after being irradiated by the CL generated from luminol and K 3 Fe(CN) 6 , the BPQDs effectively catalyze the decomposition of dissolved oxygen to produce superoxide radical anions, which further react with luminol to increase CL emission. The noticeable suppression of the CL signal in the presence of dopamine acquired under mild conditions makes it attractive for biosensor applications, deepening the understanding of BPQDs as efficient catalysts and promoting the potential development of BPQD-based materials in the fields of photonics, biomedicine, and electronics.

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“…Persistent luminescence nanoparticles (PLNPs) can store energy from the excitation source and then release it for afterglow emission. − Their non-in situ excitation could eliminate the interference from autofluorescence and scattered light. − If near-infrared (NIR) afterglow is realized for PLNPs, the imaging efficiency could be improved for the deep tissue penetration of NIR afterglow and the high resolution of optical imaging. − Thus, NIR afterglow for PLNPs with non-in situ excitation is perfect for imaging application. PLNPs are composited with the host, emission center, and trap, while emission centers govern the emission wavelength .…”

Section: Introductionmentioning

confidence: 99%

Cr-Free Bismuth-Based Persistent Luminescence Nanoparticle Composite for Cancer Theranostics

Aiwaili,

Zhao,

Abdurahman

et al. 2024

ACS Appl. Nano Mater.

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Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) showed great potential for bioimaging due to their integration of non-in situ excitation and deep tissue penetration. However, PLNPs are often introduced with Cr 3+ ions as the NIR emission centers. Herein, we report Cr-free Bi 2 Ga 3.985 O 9 :1.5% Fe 3+ (BGF), with Fe 3+ ions as the NIR emission centers. BGF under 310 nm excitation exhibited NIR afterglow emission at 794 nm in the first biological imaging window (650− 950 nm), with the afterglow duration of 3 h. BGF was grafted with hydroxyl groups and then polydopamine (PDA) for the integration of indocyanine green (ICG) through π−π stacking and hydrophobic interactions, as the PLNP−PDA−ICG composite. Bi in the composite, as a heavy atom element, exhibits computed tomography (CT) contrast capacity, while PDA is a photothermal agent, and ICG is excited to produce reactive oxide species for photodynamic therapy. The afterglow/CT dual-modality imaging-guided photothermal/photodynamic combination therapy was validated with in vitro/vivo imaging and therapeutic applications. This work provides the Cr-free PLNP composite for drug-free theranostics with a low toxicity.

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Nanomaterials for light-mediated therapeutics in deep tissue

Abstract: Different activation modes, including chemiluminescence, NIR, X-ray and ultrasound, have been employed to trigger specific light-mediated therapeutics, such as photodynamic therapy, photothermal therapy and drug delivery.

Cited by 17 publications

References 260 publications

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Black Phosphorus Quantum Dots with Exposed (113) Planes on Chemiluminescent Luminol–K₃Fe(CN)₆ for Detection of Dopamine

Cr-Free Bismuth-Based Persistent Luminescence Nanoparticle Composite for Cancer Theranostics

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Nanomaterials for light-mediated therapeutics in deep tissue

Abstract: Different activation modes, including chemiluminescence, NIR, X-ray and ultrasound, have been employed to trigger specific light-mediated therapeutics, such as photodynamic therapy, photothermal therapy and drug delivery.

Cited by 17 publications

References 260 publications

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Novel silicene-mesoporous silica nanoparticles conjugated gemcitabine induced cellular apoptosis via upregulating NF-κB p65 nuclear translocation suppresses pancreatic cancer growth in vitro and in vivo

Black Phosphorus Quantum Dots with Exposed (113) Planes on Chemiluminescent Luminol–K3Fe(CN)6 for Detection of Dopamine

Cr-Free Bismuth-Based Persistent Luminescence Nanoparticle Composite for Cancer Theranostics

Contact Info

Product

Resources

About

Black Phosphorus Quantum Dots with Exposed (113) Planes on Chemiluminescent Luminol–K₃Fe(CN)₆ for Detection of Dopamine