Nanomaterials for Parkinson disease: Recent progress

Ghazy, Esraa; Rahdar, Abbas; Barani, Mahmood; Kyzas, George Z.

doi:10.1016/j.molstruc.2020.129698

Cited by 40 publications

(20 citation statements)

References 77 publications

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“…Among the novel approaches investigated for PD treatment, most interest has been focused in recent years on the development of DA-loaded nanocarriers, since they may be able to cross the BBB enabling a sustained delivery of the neurotransmitter to the brain [ 8 , 9 ]. In this context, the present work aimed at evaluating the feasibility of the co-administration by intranasal route of DA together with antioxidant agents such as those occurring in GSE, both administered in a unique delivery system represented by SLN, in order to achieve not only the overcoming of the BBB in a non-invasive manner but also the limitation of the OS and neuroinflammation mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…A further advance made for the treatment of neurodegenerative diseases, including PD, is represented by the observation that appropriately tailored nanocarriers may be able to overcome the challenging obstacle represented by the BBB, exploiting the physiological mechanisms of transport [ 8 , 9 ]. It should be considered, indeed, that, although the BBB, in the presence of neurodegenerative disease, as PD and Alzheimer’s disease, is altered in structure and permeable enough, it still limits the brain penetration of neurotherapeutics and brain imaging agents [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

et al. 2021

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Background: The loss of nigrostriatal neurons containing dopamine (DA) together with the “mitochondrial dysfunction” in midbrain represent the two main causes related to the symptoms of Parkinson’s disease (PD). Hence, the aim of this investigation is to co-administer the missing DA and the antioxidant grape seed-derived proanthocyanidins (grape seed extract, GSE) in order to increase the levels of the neurotransmitter (which is unable to cross the Blood Brain Barrier) and reducing the oxidative stress (OS) related to PD, respectively. Methods: For this purpose, we chose Solid Lipid Nanoparticles (SLN), because they have been already proven to increase DA uptake in the brain. DA-SLN adsorbing GSE (GSE/DA-SLN) were formulated and subjected to physico-chemical characterization, and their cytocompatibility and protection against OS were examined. Results: GSE was found on SLN surface and release studies evidenced the efficiency of GSE in preventing DA autoxidation. Furthermore, SLN showed high mucoadhesive strength and were found not cytotoxic to both primary Olfactory Ensheathing and neuroblastoma SH-SY5Y cells by MTT test. Co-administration of GSE/DA-SLN and the OS-inducing neurotoxin 6-hydroxydopamine (100 μM) resulted in an increase of SH-SY5Y cell viability. Conclusions: Hence, SLN formulations containing DA and GSE may constitute interesting candidates for non-invasive nose-to-brain delivery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

et al. 2021

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“…Nanomaterials can exert their innate antimicrobial action, and synthesizing NPs while conjugating them to antimicrobials may lead to synergistic antibacterial actions, with cost-effectiveness and higher stability for a longer period [ 37 ]. Antimicrobial NPs for UTIs are mostly based on metals (gold - Au, silver - Ag, titanium NPs) and on metal-based oxides (zinc oxide-ZnO-NPs) [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. All metal and metal-based oxide NP damage the pathogenic microorganisms by various mechanisms of photothermolysis, generating reacting oxygen species (ROS), damaging the cell wall and cell components of pathogens, and interfering with normal enzymatic activities and DNA synthesis [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the metabolic activity and antimicrobial susceptibility of pathogens can be evaluated via Con-A-conjugated supermagnetic iron oxide (SPIO) nanosensors [ 69 ]. Keeping in mind all the efforts related to the synthesis of novel nanomaterials and the investigation of their potential in bioapplications [ 39 , 40 , 70 , 71 , 72 ], we next review the nanomaterials applied to the diagnosis and treatment of UTIs.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

et al. 2021

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The diagnosis and treatment of urinary tract infections (UTIs) remain challenging due to the lack of convenient assessment techniques and to the resistance to conventional antimicrobial therapy, showing the need for novel approaches to address such problems. In this regard, nanotechnology has a strong potential for both the diagnosis and therapy of UTIs via controlled delivery of antimicrobials upon stable, effective and sustained drug release. On one side, nanoscience allowed the production of various nanomaterial-based evaluation tools as precise, effective, and rapid procedures for the identification of UTIs. On the other side, nanotechnology brought tremendous breakthroughs for the treatment of UTIs based on the use of metallic nanoparticles (NPs) for instance, owing to the antimicrobial properties of metals, or of surface-tailored nanocarriers, allowing to overcome multidrug-resistance and prevent biofilm formation via targeted drug delivery to desired sites of action and preventing the development of cytotoxic processes in healthy cells. The goal of the current study is therefore to present the newest developments for the diagnosis and treatment of UTIs based on nanotechnology procedures in relation to the currently available techniques.

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“…Nowadays, nanotechnology is emerging as an exciting field that finds broad-spectrum applications in nutrition, cosmetics, and biomedical products to improve the bioavailability of therapeutic molecules or drugs [ 3 , 4 , 6 , 8 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In contrast to larger-scale counterparts, nanoscale materials often display more appealing physical and chemical attributes as well as attractive biological potentialities [ 19 , 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

et al. 2021

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Curcumin is known to exhibit antioxidant and tissue-healing properties and has recently attracted the attention of the biomedical community for potential use in advanced therapies. This work reports the formulation and characterization of oil-in-water F127 microemulsions to enhance the bioavailability of curcumin Microemulsions showed a high encapsulation efficiency and prolonged release. To investigate the interactions of curcumin with one unit of the polymeric chain of surfactant F127, ethyl butyrate, and sodium octanoate, as well as the interaction between ethyl butyrate and one unit of the F127 polymer chain, the Density Functional Theory (DFT) calculations at the M06-2X level of theory, were performed in water solution. The MTT assay was used to assess the cytotoxicity of free and encapsulated curcumin on non-malignant and malignant cell lines. Combination effects were calculated according to Chou-Talalay’s principles. Results of in vitro studies indicated that MCF7 and HepG2 cells were more sensitive to curcumin microemulsions. Moreover, a synergistic relationship was observed between curcumin microemulsions and cisplatin in all affected fractions of MCF7 and HepG2 cells (CI < 0.9). For in vivo investigation, thioacetamide-intoxicated rats received thioacetamide (100 mg/kg Sc) followed by curcumin microemulsions (30 mg/kg Ip). Thioacetamide-intoxicated rats showed elevated serum liver enzymes, blood urea nitrogen (BUN), and creatinine levels, and a significant reduction in liver superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05). Curcumin microemulsions reduced liver enzymes and serum creatinine and increased the activity of antioxidant enzymes in thioacetamide-treated rats in comparison to the untreated thioacetamide-intoxicated group. Histopathological investigations confirmed the biochemical findings. Overall, the current results showed the desirable hepatoprotective, nephroprotective, and anti-cancer effects of curcumin microemulsions.

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Nanomaterials for Parkinson disease: Recent progress

Cited by 40 publications

References 77 publications

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

Cyto/Biocompatibility of Dopamine Combined with the Antioxidant Grape Seed-Derived Polyphenol Compounds in Solid Lipid Nanoparticles

Nanomaterials for the Diagnosis and Treatment of Urinary Tract Infections

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

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