Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives

Zong, Chen; Bronckaers, Annelies; Willems, Guy; He, Hong; Llano-Pérula, María Cadenas de

doi:10.3390/jfb14060290

Cited by 8 publications

(4 citation statements)

References 118 publications

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“…[ 302 ] Emerging technologies include bioactive nanomaterials, multilayered scaffolds, stem cells, bone anabolic agents, and genetic therapies. [ 276 , 302 , 304 , 305 , 306 ] Nevertheless, these technologies are still complex and in their early stage. Indeed, further evidence is required to fulfil the regulatory requirements for implementation in a clinical context.…”

Section: Discussionmentioning

confidence: 99%

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

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Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss. A step‐wise therapeutic approach is employed for periodontitis. After an initial behavioral and non‐surgical phase, intra‐bony or furcation defects may be amenable to regenerative procedures. This review discusses the regenerative technologies employed for periodontal regeneration, highlighting the current limitations and future research areas. The search, performed on the MEDLINE database, has identified the available biomaterials, including biologicals (autologous platelet concentrates, hydrogels), bone grafts (pure or putty), and membranes. Biologicals and bone grafts have been critically analyzed in terms of composition, mechanism of action, and clinical applications. Although a certain degree of periodontal regeneration is predictable in intra‐bony and class II furcation defects, complete defect closure is hardly achieved. Moreover, treating class III furcation defects remains challenging. The key properties required for functional regeneration are discussed, and none of the commercially available biomaterials possess all the ideal characteristics. Therefore, research is needed to promote the advancement of more effective and targeted regenerative therapies for periodontitis. Lastly, improving the design and reporting of clinical studies is suggested by strictly adhering to the Consolidated Standards of Reporting Trials (CONSORT) 2010 statement.

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Section: Discussionmentioning

confidence: 99%

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

De Lauretis,

Øvrebø,

Romandini

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

“…According to a recent literature review, the most researched materials for bone regeneration were represented by nanohydroxyapatite and collagen. Both materials present excellent osteoconductive, mechanical and biological properties [142]. Polylactic glycolic acid and polycaprolactone are intensively studied for use in tissue engineering and regenerative medicine due to their ability to degrade into compounds that can be easily metabolized and excreted.…”

Section: Biomaterials Functionalized With Inflammasome Inhibitorsmentioning

confidence: 99%

Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives

Vinţeler,

Feurdean,

Petkes

et al. 2024

JFB

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This review aimed at searching literature for data regarding the inflammasomes’ involvement in the pathogenesis of oral diseases (mainly periodontitis) and general pathologies, including approaches to control inflammasome-related pathogenic mechanisms. The inflammasomes are part of the innate immune response that activates inflammatory caspases by canonical and noncanonical pathways, to control the activity of Gasdermin D. Once an inflammasome is activated, pro-inflammatory cytokines, such as interleukins, are released. Thus, inflammasomes are involved in inflammatory, autoimmune and autoinflammatory diseases. The review also investigated novel therapies based on the use of phytochemicals and pharmaceutical substances for inhibiting inflammasome activity. Pharmaceutical substances can control the inflammasomes by three mechanisms: inhibiting the intracellular signaling pathways (Allopurinol and SS-31), blocking inflammasome components (VX-765, Emricasan and VX-740), and inhibiting cytokines mediated by the inflammasomes (Canakinumab, Anakinra and Rilonacept). Moreover, phytochemicals inhibit the inflammasomes by neutralizing reactive oxygen species. Biomaterials functionalized by the adsorption of therapeutic agents onto different nanomaterials could represent future research directions to facilitate multimodal and sequential treatment in oral pathologies.

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“…While nanomaterial-based transplants offer a potential solution for covering and protecting alveolar bone defects, the direct exposure of the gingival wound or recessive gingiva to the intricate oral microenvironment poses challenges. The application of nanomaterials could potentially alter the gingiva's color, shape, and texture, significantly impacting smile aesthetics, especially in the context of anterior teeth [151].…”

Section: Gingival Regenerationmentioning

confidence: 99%

Advancing Dentistry through Bioprinting: Personalization of Oral Tissues

Shopova,

Mihaylova,

Yaneva

et al. 2023

JFB

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Despite significant advancements in dental tissue restoration and the use of prostheses for addressing tooth loss, the prevailing clinical approaches remain somewhat inadequate for replicating native dental tissue characteristics. The emergence of three-dimensional (3D) bioprinting offers a promising innovation within the fields of regenerative medicine and tissue engineering. This technology offers notable precision and efficiency, thereby introducing a fresh avenue for tissue regeneration. Unlike the traditional framework encompassing scaffolds, cells, and signaling factors, 3D bioprinting constitutes a contemporary addition to the arsenal of tissue engineering tools. The ongoing shift from conventional dentistry to a more personalized paradigm, principally under the guidance of bioprinting, is poised to exert a significant influence in the foreseeable future. This systematic review undertakes the task of aggregating and analyzing insights related to the application of bioprinting in the context of regenerative dentistry. Adhering to PRISMA guidelines, an exhaustive literature survey spanning the years 2019 to 2023 was performed across prominent databases including PubMed, Scopus, Google Scholar, and ScienceDirect. The landscape of regenerative dentistry has ushered in novel prospects for dentoalveolar treatments and personalized interventions. This review expounds on contemporary accomplishments and avenues for the regeneration of pulp—dentin, bone, periodontal tissues, and gingival tissues. The progressive strides achieved in the realm of bioprinting hold the potential to not only enhance the quality of life but also to catalyze transformative shifts within the domains of medical and dental practices.

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Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives

Cited by 8 publications

References 118 publications

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

From Basic Science to Clinical Practice: A Review of Current Periodontal/Mucogingival Regenerative Biomaterials

Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives

Advancing Dentistry through Bioprinting: Personalization of Oral Tissues

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