Nanomaterials for the theranostics of obesity

Li, Juanjuan; Cha, Ruitao; Luo, Huize; Hao, Wenshuai; Zhang, Yan; Jiang, Xingyu

doi:10.1016/j.biomaterials.2019.119474

Cited by 31 publications

(18 citation statements)

References 179 publications

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“…In addition, obesity also increases the incidence of tumors such as prostate, uterine, and breast cancers [ 12 ]. Based on etiology and pathogenesis, obesity can be simply divided into simple obesity and pathological obesity [ 13 ]. Simple obesity is linked to poor lifestyle behaviors.…”

Section: Introductionmentioning

confidence: 99%

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Duan

Liu

et al. 2022

Pharmaceutics

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Obesity is a global public health issue that results in many health complications or comorbidities, including type 2 diabetes mellitus, cardiovascular disease, and fatty liver. Pharmacotherapy alone or combined with either lifestyle alteration or surgery represents the main modality to combat obesity and its complications. However, most anti-obesity drugs are limited by their bioavailability, target specificity, and potential toxic effects. Only a handful of drugs, including orlistat, liraglutide, and semaglutide, are currently approved for clinical obesity treatment. Thus, there is an urgent need for alternative treatment strategies. Based on the new revelation of the pathogenesis of obesity and the efforts toward the multi-disciplinary integration of materials, chemistry, biotechnology, and pharmacy, some emerging obesity treatment strategies are gradually entering the field of preclinical and clinical research. Herein, by analyzing the current situation and challenges of various new obesity treatment strategies such as small-molecule drugs, natural drugs, and biotechnology drugs, the advanced functions and prospects of biomaterials in obesity-targeted delivery, as well as their biological activities and applications in obesity treatment, are systematically summarized. Finally, based on the systematic analysis of biomaterial-based obesity therapeutic strategies, the future prospects and challenges in this field are proposed.

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Section: Introductionmentioning

confidence: 99%

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Duan

Liu

et al. 2022

Pharmaceutics

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“…In this way, titanium, silver, and zinc metals were used to design metallic NPs via synthetic or natural methods to reinforce pharmacological and medical applications [ 6 ]. Nanomaterials have a vast surface area, strong absorptivity, and high bioavailability, especially the good targeting properties and adjustable release rate, which might benefit the diagnosis and treatment of obesity and obesity-related diseases [ 7 ]. In this regard, manganese tetroxide nanoparticles (MnNPs, around 250 nm) were integrated into electrospun short fibers (SF@Rsg-Mn) and used to treat a diet-induced obesity mouse model; these nanoparticles led to weight loss by reducing fat, improvement in lipid metabolism, and a decrease in adverse effects on other tissues [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Lipid Accumulation and Adipokine Levels in Maturing Adipocytes by Bauhinia rufescens (Lam.) Stem Bark Extract Loaded Titanium Oxide Nanoparticles

et al. 2021

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The present study reports a cost-effective, environmentally friendly method to increase the bioavailability and bio-efficacy of B. rufescens stem bark extract in the biological system via functional modification as B. rufescens stem bark nanoparticles (BR-TO2-NPs). The biosynthesis of BR- -NPs was confirmed by UV-visible (UV-vis) and Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), and X-ray diffraction analyses. The shifts in FT-IR stretching vibrations of carboxylic and nitro groups (1615 cm−1), the O–H of phenolics or carboxylic acids (3405 cm−1), alkanes, and alkyne groups (2925 and 2224 cm−1) of the plant extract and lattice (455) indicated successful biosynthesis of BR- -NPs. Compared with the stem bark extract, 40 ng/dL dose of BR- -NPs led to a reduction in adipogenesis and an increase in mitochondrial biogenesis-related gene expressions, adiponectin-R1, PPARγC1α, UCP-1, and PRDM16, in maturing-adipocytes. This confirmed the intracellular uptake, bioavailability, and bio-efficiency of BR-TiO2-NPs. The lipid-lowering capacity of BR-TiO2-NPs effectively inhibited the metabolic inflammation-related gene markers, IL-6, TNF-α, LTB4-R, and Nf-κb. Further, BR-TiO2-NPs stimulating mitochondrial thermogenesis capacity was proven by the significantly enhanced CREB-1 and AMPK protein levels in adipocytes. In conclusion, BR-TiO2-NPs effectively inhibited lipid accumulation and proinflammatory adipokine levels in maturing adipocytes; it may help to overcome obesity-associated comorbidities.

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“…17 The major advantages offered by nanomaterials are the shape, surface area, and particle size, 18 which confer unique optical, 19 mechanical, 20 electrical, 21 and physicochemical properties. 22 These advantages also provide a high reactivity for the modification with organic and inorganic molecules, 23 allowing the synthesis of engineered nanomaterials for an extended range of applications, including a more efficient environmental remediation. 24 The engineered nanomaterials bring a double benefit to the environment because many are considered greener and safer, and the synthesis methods can follow the environmental sustainability approach.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Different types of innovative materials in the nanoscale are being developed based on market demand, covering several industrial fields such as textiles, food, health, and the environment . The major advantages offered by nanomaterials are the shape, surface area, and particle size, which confer unique optical, mechanical, electrical, and physicochemical properties . These advantages also provide a high reactivity for the modification with organic and inorganic molecules, allowing the synthesis of engineered nanomaterials for an extended range of applications, including a more efficient environmental remediation .…”

Section: Introductionmentioning

confidence: 99%

Environmental and Exergetic Analysis of Large-Scale Production of Citric Acid-Coated Magnetite Nanoparticles via Computer-Aided Process Engineering Tools

et al. 2021

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Considering that functional magnetite (Fe 3 O 4 ) nanoparticles with exceptional physicochemical properties can be highly applicable in different fields, scaling-up strategies are becoming important for their large-scale production. This study reports simulations of scaled-up production of citric acid-coated magnetite nanoparticles (Fe 3 O 4 -cit), aiming to evaluate the potential environmental impacts (PEIs) and the exergetic efficiency. The simulations were performed using the waste reduction algorithm and the Aspen Plus software. PEI and energy/exergy performance are calculated and quantified. The inlet and outlet streams are estimated by expanding the mass and energy flow, setting operating parameters of processing units, and defining a thermodynamic model for properties estimation. The high environmental performance of the production process is attributed to the low outlet rate of PEI compared to the inlet rate. The product streams generate low PEI contribution (−3.2 × 10 3 PEI/y) because of the generation of environmentally friendlier substances. The highest results in human toxicity potential (3.2 × 10 3 PEI/y), terrestrial toxicity potential (3.2 × 10 3 PEI/y), and photochemical oxidation potential (2.6 × 10 4 PEI/y) are attributed to the ethanol within the waste streams. The energy source contribution is considerably low with 27 PEI/y in the acidification potential ascribed to the elevated levels of hydrogen ions into the atmosphere. The global exergy of 1.38% is attributed to the high irreversibilities (1.7 × 10 5 MJ/h) in the separation stage, especially, to the centrifuge CF-2 (5.07%). The sensitivity analysis establishes that the global exergy efficiency increases when the performance of the centrifuge CF-2 is improved, suggesting to address enhancements toward low disposal of ethanol in the wastewater.

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Nanomaterials for the theranostics of obesity

Cited by 31 publications

References 179 publications

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Biomaterial-Based Therapeutic Strategies for Obesity and Its Comorbidities

Inhibition of Lipid Accumulation and Adipokine Levels in Maturing Adipocytes by Bauhinia rufescens (Lam.) Stem Bark Extract Loaded Titanium Oxide Nanoparticles

Environmental and Exergetic Analysis of Large-Scale Production of Citric Acid-Coated Magnetite Nanoparticles via Computer-Aided Process Engineering Tools

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