Nanomaterials in Bone Regeneration

Babuška, Václav; Kasi, Phanindra Babu; Chocholata, Petra; Wiesnerová, Lucie; Dvořáková, Jana; Vrzakova, Radana; Nekleionova, Anna; Landsmann, Lukas; Kulda, Vlastimil

doi:10.3390/app12136793

Cited by 29 publications

(20 citation statements)

References 216 publications

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“…Altering the surface morphology at the nanoscale can confer distinct surface characteristics to the material. Various techniques can be employed to create micro-nanostructures on implant surfaces, including electrochemical methods like electrodeposition, anodization, micro-arc oxygen, and mechanical coating techniques such as ionomer surface engineering and magnetron sputtering [69]. Electrodeposition is a widely used technique to apply a layer of specific elements onto the existing surface structure [70].…”

Section: Surface Modificationmentioning

confidence: 99%

3D-printed porous tantalum artificial bone scaffolds: fabrication, properties, and applications

Yu,

Xu,

Duan

et al. 2024

Biomed. Mater.

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Porous tantalum scaffolds offer a high degree of biocompatibility and have a low friction coefficient. In addition, their biomimetic porous structure and mechanical properties, which closely resemble human bone tissue, make them a popular area of research in the field of bone defect repair. With the rapid advancement of additive manufacturing, 3D-printed porous tantalum scaffolds have increasingly emerged in recent years, offering exceptional design flexibility, as well as facilitating the fabrication of intricate geometries and complex pore structures that similar to human anatomy. This review provides a comprehensive description of the techniques, procedures, and specific parameters involved in the 3D printing of porous tantalum scaffolds. Concurrently, the review provides a summary of the mechanical properties, osteogenesis and antibacterial properties of porous tantalum scaffolds. The use of surface modification techniques and the drug carriers can enhance the characteristics of porous tantalum scaffolds. Accordingly, the review discusses the application of these porous tantalum materials in clinical settings. Multiple studies have demonstrated that 3D-printed porous tantalum scaffolds exhibit exceptional corrosion resistance, biocompatibility, and osteogenic properties. As a result, they are considered highly suitable biomaterials for repairing bone defects. Despite the rapid development of 3D-printed porous tantalum scaffolds, they still encounter challenges and issues when used as bone defect implants in clinical applications. Ultimately, a concise overview of the primary challenges faced by 3D-printed porous tantalum scaffolds is offered, and corresponding insights to promote further exploration and advancement in this domain are presented.

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Section: Surface Modificationmentioning

confidence: 99%

3D-printed porous tantalum artificial bone scaffolds: fabrication, properties, and applications

Yu,

Xu,

Duan

et al. 2024

Biomed. Mater.

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“…This customization can result in enhanced cellular uptake and more effective interaction with the host’s immune and progenitor cells at the nanoscale level, leading to improved outcomes in bone regeneration [ 19 ]. In addition, the reduction in material size to the nanoscale significantly increases the surface area, surface roughness, and ratio of surface area to volume, leading to superior physicochemical properties [ 20 ]. NPs also exert influence on cell signaling, proliferation, and viability.…”

Section: Nanostructured Materials For Enhanced Bone Regenerationmentioning

confidence: 99%

Harnessing the Potential of PLGA Nanoparticles for Enhanced Bone Regeneration

Hassan,

Abdelnabi,

Mohsin

2024

Pharmaceutics

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Recently, nanotechnologies have become increasingly prominent in the field of bone tissue engineering (BTE), offering substantial potential to advance the field forward. These advancements manifest in two primary ways: the localized application of nanoengineered materials to enhance bone regeneration and their use as nanovehicles for delivering bioactive compounds. Despite significant progress in the development of bone substitutes over the past few decades, it is worth noting that the quest to identify the optimal biomaterial for bone regeneration remains a subject of intense debate. Ever since its initial discovery, poly(lactic-co-glycolic acid) (PLGA) has found widespread use in BTE due to its favorable biocompatibility and customizable biodegradability. This review provides an overview of contemporary advancements in the development of bone regeneration materials using PLGA polymers. The review covers some of the properties of PLGA, with a special focus on modifications of these properties towards bone regeneration. Furthermore, we delve into the techniques for synthesizing PLGA nanoparticles (NPs), the diverse forms in which these NPs can be fabricated, and the bioactive molecules that exhibit therapeutic potential for promoting bone regeneration. Additionally, we addressed some of the current concerns regarding the safety of PLGA NPs and PLGA-based products available on the market. Finally, we briefly discussed some of the current challenges and proposed some strategies to functionally enhance the fabrication of PLGA NPs towards BTE. We envisage that the utilization of PLGA NP holds significant potential as a potent tool in advancing therapies for intractable bone diseases.

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“…Due to their nanoscale dimensions, nanoparticles exhibit greater availability in biological systems. 69 They include nanospheres, nanowires, nanofilms, nanotubes, and many more. The nanoscale reduction in material size dramatically increases surface area, roughness, and the ratio of surface area to volume, resulting in enhanced physiochemical characteristics.…”

Section: Bioinert Nanoceramics Reinforced Chitosan Scaffoldsmentioning

confidence: 99%