Nanomaterials in wound healing: From material sciences to wound healing applications

Barroso, Andreia Filipa Nobre; Mestre, Henrique; Ascenso, Andreia; Simões, Sandra; Reis, Catarina Pinto

doi:10.1002/nano.202000055

Cited by 91 publications

(48 citation statements)

References 101 publications

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“…Nano‐materials with unique physical and chemical properties have received considerable attention in recent decades. [ 1–7 ] Its stability and duration are the most significant to design interfacial materials and micro‐electro‐mechanical systems, including superhydrophobicity, icephobicity, self‐cleaning, soft electronic circuits, and sensing systems. [ 8–14 ] However, the nano‐materials are always be ruined due to the base with weak mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Design of flexible multi‐level topography for enhancing mechanical property

Wang

Zhao³

et al. 2020

Nano Select

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Robust mechanical property is fundamentally significant for applications of nano‐materials, such as micro‐fluidic, sensor, superhydrophobic/ icephobic, and crush‐resistant functions. However, the nano‐materials used in the applications are always easily ruined due to the poor adhesion and weak mechanical properties. To enhance the nano‐materials’ duration in hash environment, a strategy of robust nano‐topography protection is studied in this paper. In our experiment, a series of multi‐level sub‐mm topography with nano‐materials are fabricated by integrating the methods of soft lithography, and crystal growth. The mechanical properties of nano‐materials are quantitatively studied, and the nano‐material can be protected by the designed flexible multi‐level topography, which significantly decreases the strain and stress of the nano‐structure. To investigate the mechanism of this performance, a series of simulations are performed, and a mechanical model is established to explain this phenomenon. This work uncovers the multi‐level principles for nano‐materials protection and gives a guideline to design the nano‐materials’ surfaces.

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Section: Introductionmentioning

confidence: 99%

Design of flexible multi‐level topography for enhancing mechanical property

Wang

Zhao³

et al. 2020

Nano Select

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“…Furthermore, it is well known that nanoparticles exhibit great benefits in accelerating wound healing, including re-epithelialization property, tissue adhesion, and differentiation. [49] According to our previous work, it was demonstrated that the catechol groups of PDA could scavenge radical and played a key role to accelerate the wound healing process. [37] In addition, the conductivity of PPy also plays a significant role in different stages of the wound healing process.…”

Section: In Vivo Wound Healing Performance and Histological Analysesmentioning

confidence: 99%

Smart Asymmetric Hydrogel with Integrated Multi‐Functions of NIR‐Triggered Tunable Adhesion, Self‐Deformation, and Bacterial Eradication

Feng

Shi

Chen

et al. 2021

Adv Healthcare Materials

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Multifunctional hydrogels acting as wound dressing have received extensive attention in soft tissue repair; however, it is still a challenge to develop a non-antibiotic-dependent antibacterial hydrogel that has tunable adhesion and deformation to achieve on-demand removal. Herein, an asymmetric adhesive hydrogel with near-infrared (NIR)-triggered tunable adhesion, self-deformation, and bacterial eradication is designed. The hydrogel is prepared by the crosslinking polymerization of N-isopropylacrylamide and acrylic acid, during the sedimentation of conductive PPy-PDA nanoparticles based on the polymerization of pyrrole (Py) and dopamine (DA). Due to the conversion capacity from NIR light into heat for PPy-PDA NPs, the formed temperature-sensitive hydrogel exhibits tissue adhesive as well as NIR-triggered tunable adhesion and self-deformation property, which can achieve an on-demand dressing refreshing. Systematically in vitro/in vivo antibacterial experiments indicate that the hydrogel shows excellent disinfection capability to both Gram-negative and Gram-positive bacteria. The in vivo experiments in a full-layer cutaneous wound model demonstrate that the hydrogel has a good treatment effect to promote wound healing. Overall, the asymmetric hydrogel with tunable adhesion, self-deformation, conductive, and photothermal antibacterial activity may be a promising candidate to fulfill the functions of adhesion on skin tissue, easy removing on-demand, and accelerating the wound healing process.

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“…Prior to clinical evaluation of these wound-healing formulations, acceptability and efficacy must be assessed in comparison with conventional treatment options. Indeed, the most important steps in the development of wound care formulations are the evaluation of biocompatibility, antimicrobial activity and in vivo wound-healing activity [ 91 ]. Table 1 presents major newly developed formulations that are still to be fully assessed within pre-clinical studies.…”

Section: Health Benefits Of Bee Products With Focus On Regenerative Medicinementioning

confidence: 99%

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

Peršurić

Pavelić

2021

Molecules

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In recent years, interest has surged among researchers to determine compounds from bee products such as honey, royal jelly, propolis and bee pollen, which are beneficial to human health. Mass spectrometry techniques have shown that bee products contain a number of proven health-promoting compounds but also revealed rather high diversity in the chemical composition of bee products depending on several factors, such as for example botanical sources and geographical origin. In the present paper, we present recent scientific advances in the field of major bioactive compounds from bee products and corresponding regenerative properties. We also discuss extracellular vesicles from bee products as a potential novel bioactive nutraceutical component. Extracellular vesicles are cell-derived membranous structures that show promising potential in various therapeutic areas. It has been extensively reported that the use of vesicles, which are naturally formed in plant and animal cells, as delivery agents have many advantages. Whether the use of extracellular vesicles from bee products represents a new solution for wound healing remains still to be elucidated. However, promising results in specific applications of the bee products in wound healing and tissue regenerative properties of extracellular vesicles provide a good rationale to further explore this idea.

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Nanomaterials in wound healing: From material sciences to wound healing applications

Cited by 91 publications

References 101 publications

Design of flexible multi‐level topography for enhancing mechanical property

Design of flexible multi‐level topography for enhancing mechanical property

Smart Asymmetric Hydrogel with Integrated Multi‐Functions of NIR‐Triggered Tunable Adhesion, Self‐Deformation, and Bacterial Eradication

Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing

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